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排序方式: 共有392条查询结果,搜索用时 62 毫秒
91.
92.
AlessandroGiordano MariaLuciaCalcagni FrancescoDellaCorte MarianoAlbertoPennisi Guido Galli 王凤琴 赵惠杨 《核技术(英文版)》1993,(1)
Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean CBF by AVDO2 according to the Fick's principle. The mean values of CBF, AVDO2 and CMRO2 in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO2 demonstrated an intermediate accuracy in separating the two groups, while CMRO2 showed a satisfactory accuracy. 相似文献
93.
94.
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages
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Dr. Marco Paolino Dr. Margherita Brindisi Dr. Alessandra Vallone Prof. Stefania Butini Prof. Giuseppe Campiani Dr. Chiara Nannicini Germano Giuliani Prof. Maurizio Anzini Dr. Stefania Lamponi Prof. Gianluca Giorgi Prof. Diego Sbardella Dr. Davide M. Ferraris Prof. Stefano Marini Prof. Massimo Coletta Dr. Ivana Palucci Dr. Mariachiara Minerva Prof. Giovanni Delogu Dr. Ilaria Pepponi Dr. Delia Goletti Prof. Andrea Cappelli Sandra Gemma Dr. Simone Brogi 《ChemMedChem》2018,13(5):422-430
The enzyme Zmp1 is a zinc‐containing peptidase that plays a critical role in the pathogenicity of Mycobacterium tuberculosis. Herein we describe the identification of a small set of Zmp1 inhibitors based on a novel 8‐hydroxyquinoline‐2‐hydroxamate scaffold. Among the synthesized compounds, N‐(benzyloxy)‐8‐hydroxyquinoline‐2‐carboxamide ( 1 c ) was found to be the most potent Zmp1 inhibitor known to date, and its binding mode was analyzed both by kinetics studies and molecular modeling, identifying critical interactions of 1 c with the zinc ion and residues in the active site. The effect of 1 c on intracellular Mycobacterium survival was assayed in J774 murine macrophages infected with M. tuberculosis H37Rv or M. bovis BCG and human monocyte‐derived macrophages infected with M. tuberculosis H37Rv. Cytotoxicity and genotoxicity were also assessed. Overall, inhibitor 1 c displays interesting in vitro antitubercular properties worthy of further investigation. 相似文献
95.
Vasilica Lates Delia Gligor Mircea Darabantu Liana M. Muresan 《Journal of Applied Electrochemistry》2007,37(5):631-636
The electrochemical behavior of a new G-2-s-triazine-based dendrimer, 2,4,6-tris-{4-{4,6-bis-{4-{4,6-bis-[(1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)-prop-2-ylamino]-s-triazin-2-yl}-piperazin-1-yl}-s-triazin-2-yl}-piperazin-1-yl}-s-triazine, (I), was studied in dimethylsulfoxide solution by cyclic voltammetry, on platinum and graphite electrodes. The electrochemical
properties of I were compared with that of one of its precursor, N-{4,6-bis{4-{4,6-bis[(1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)-prop-2-ylamino]-s-triazin-2-yl}-piperazin-1-yl}-triazin-2-yl}-piperazine), (II), together with that of the starting material, (1S,2S)-2-amino-1-(4-nitrophenyl)-propane-1,3-diol (“p-nitrophenylserinol”), (III). 相似文献
96.
József Molnár Dmitry Chetverikov Delia Cabrera DeBuc Wei Gao Gábor Márk Somfai 《Machine Vision and Applications》2012,23(6):1129-1139
Optical coherence tomography (OCT) is a modern technique that allows for in vivo, fast, high-resolution 3D imaging. OCT can be efficiently used in eye research and diagnostics, when retinal images are processed to extract borders of retinal layers. In this paper, we present two novel algorithms for delineation of three main borders in rodent retinal images. The first, fast algorithm is based on row projections in a sliding window. It provides initial borders for a slower but more precise variational algorithm that iteratively refines the borders. The results obtained by the two algorithms are quantitatively evaluated by comparison to the borders manually extracted in a set of retinal images. 相似文献
97.
98.
Screening and HPLC methods for carotenoids in sweetpotato, cassava and maize for plant breeding trials 总被引:2,自引:0,他引:2
Mieko Kimura Cintia N. Kobori Delia B. Rodriguez-Amaya Penelope Nestel 《Food chemistry》2007,100(4):1734-1746
Analytical methods for sweetpotato, cassava and maize were developed. In orange and salmon-fleshed sweetpotatoes, (all-E)-β-carotene predominated and results of spectrophotometric screening and HPLC quantification did not differ significantly. In yellow-fleshed sweetpotato and cassava, however, spectrophotometric screening overestimated the HPLC values because of the presence of several minor carotenoids. Aside from (all-E)-β-carotene, Z-isomers were present in cassava in appreciable amounts. For both crops, extraction with acetone or tetrahydrofuran:methanol (1:1), using a mortar and pestle or a Polytron homogenizer, gave equivalent results. Rehydration of dry maize at room temperature for 30 min or at 85 °C for 5, 10 or 15 min gave equivalent results. Concentrations obtained with the C18 and C30 columns did not differ significantly for zeaxanthin, lutein, β-cryptoxanthin and β-carotene in the all-E-configuration, but their Z-isomers were difficult to locate in the chromatogram obtained with the C30 column. Extraction with tetrahydrofuran:methanol (1:1) gave significantly lower results for zeaxanthin and lutein. 相似文献
99.
Gennara Cavallaro Mariano Licciardi Delia Mandracchia Giovanna Pitarresi Gaetano Giammona 《Polymer International》2008,57(5):708-713
BACKGROUND: The design of polymeric vectors for gene delivery provided with specific properties is one of the most critical aspects for a successful gene therapy. These polymers should be biocompatible as well as able to carry efficiently DNA to target tissues and to transfect it into cells. RESULTS: The formation of complexes of poly[(α,β‐asparthylhydrazide)–poly(ethylene glycol)] and poly[(α,β‐asparthylhydrazide)–hexadecylamine] copolymers functionalised with glycidyltrimethylammonium chloride (PAHy–PEG‐GTA and PAHy–C16‐GTA, respectively) with DNA was studied. The effects of the introduction of hydrophilic (PEG) or hydrophobic (C16) moieties on the chains of PAHy–GTA copolymers, such as the stabilising effect on the DNA structure, were evaluated. In particular, we observed a high DNA protection by PAHy–PEG‐GTA copolymers. Degradation studies led us to suppose a particular aqueous conformation of the polyionic complex of PAHy–PEG2000‐GTA in which DNA should be internalised into an inner core surrounded by a PEG hydrophilic shell; while no significant protection was detected with PAHy–C16‐GTA in which DNA should be disposed on the surface of the complex, freely exposed to DNase II action. CONCLUSION: The insertion of PEG or C16 chains into the polymeric structure of PAHy–GTA copolymers changes significantly the DNA complexing and protecting ability of the PAHy–GTA copolymers, showing that hydrophilic and hydrophobic side chains can play a crucial role in supramolecular arrangements of interpolyelectrolyte complexes between DNA and PAHy copolymers. Copyright © 2008 Society of Chemical Industry 相似文献
100.
Sophie Dulon Sandrine Parot Marie-Line Delia Alain Bergel 《Journal of Applied Electrochemistry》2007,37(1):173-179
This work demonstrates that electrochemical reactions can be catalysed by the natural biofilms that form on electrode surfaces
dipping into drinking water or compost. In drinking water, oxygen reduction was monitored with stainless steel ultra-microelectrodes
under constant potential electrolysis at −0.30 V/SCE for 13 days. 16 independent experiments were conducted in drinking water,
either pure or with the addition of acetate or dextrose. In most cases, the current increased and reached 1.5–9.5 times the
initial current. The current increase was attributed to biofilm forming on the electrode in a similar way to that has been
observed in seawater. Epifluorescence microscopy showed that the bacteria size and the biofilm morphology depended on the
nutrients added, but no quantitative correlation between biofilm morphology and current was established. In compost, the oxidation
process was investigated using a titanium based electrode under constant polarisation in the range 0.10–0.70 V/SCE. It was
demonstrated that the indigenous micro-organisms were responsible for the current increase observed after a few days, up to
60 mA m−2. Adding 10 mm acetate to the compost amplified the current density to 145 mA m−2 at 0.50 V/SCE. The study suggests that many natural environments, other than marine sediments, waste waters and seawaters
that have been predominantly investigated until now, may be able to produce electrochemically active biofilms. 相似文献