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31.
Jincy Joy Jessica Pereira Rachida Aid‐Launais Graciela Pavon‐Djavid Alok R Ray Didier Letourneur Anne Meddahi‐Pell Bhuvanesh Gupta 《Polymer International》2019,68(7):1367-1377
The work reported involved the fabrication of an electrospun tubular conduit of a gelatin and polycaprolactone (PCL) blend as an adventitia‐equivalent construct. Gelatin was included as the matrix for increased biocompatibility with the addition of PCL for durability. This is contrary to most of the literature available for biomaterials based on blends of gelatin and PCL where PCL is the major matrix. The work includes the assiduous selection of key electrospinning parameters to obtain smooth bead‐free fibres with a narrow distribution of pore size and fibre diameter. Few reports elucidate the optimization of all electrospinning parameters to fabricate tubular conduits with a focus on obtaining homogeneous pores and fibres. This stepwise investigation would be unique for the fabrication of gelatin–PCL electrospun tubular constructs. The fabricated microfibrous gelatin–PCL constructs had pores of size ca 50–100 μm reportedly conducive for cell infiltration. The measured value of surface roughness of 57.99 ± 17.4 nm is reported to be favourable for protein adhesion and cell adhesion. The elastic modulus was observed to be similar to that of the tunica adventitia of the native artery. Preliminary in vitro and in vivo biocompatibility tests suggest safe applicability as a biomaterial. Minimal cytotoxicity was observed using MTT assay. Subcutaneous implantation of the scaffold demonstrated acute inflammation which decreased by day 15. The findings of this study could enable the fabrication of smooth bead‐free microfibrous gelatin–PCL tubular construct as viable biomaterial which can be included in a bilayer or a trilayer scaffold for vascular tissue engineering. © 2019 Society of Chemical Industry 相似文献
32.
Flaender M Sicoli G Aci-Seche S Reignier T Maurel V Saint-Pierre C Boulard Y Gambarelli S Gasparutto D 《Chembiochem : a European journal of chemical biology》2011,12(17):2560-2563
In a spin: Spin-labeled oligonucleotides produced by click chemistry can be studied by EPR, by using a DEER sequence. This was used to test a complex triple-labeling strategy with damaged DNA. Extensive and accurate analysis of DNA structure and enzymatic repair processes were performed after digestion by EndoIV. Modified DNA structures and DNA-protein interactions can now be readily studied. 相似文献
33.
Virginie Dulong Renauld Forbice Eric Condamine Didier Le Cerf Luc Picton 《Polymer Bulletin》2011,67(3):455-466
Rheological and swelling properties of hydrogels based on pullulan crosslinked with sodium trimetaphosphate (STMP) are explained according to various polymer and crosslinking agent concentrations using 31P-nuclear magnetic resonance study. This method has allowed determining the amount of all the species present in the medium when varying both pullulan and STMP concentrations. We have clearly demonstrated with a good agreement by both 31P-NMR and rheology that a critical STMP concentration occurs which is function of pullulan concentration. This typical crosslinking agent concentration delimitates the maximum of gel structure together with the minimum of swelling. 相似文献
34.
Nicolas Mackiewicz Thomas Bark Bertrand Cao Jacques A. Delaire Didier Riehl Wai Li Ling Stéphanie Foillard Eric Doris 《Carbon》2011,49(12):3998-4003
We report the synthesis, characterization and optical limiting behavior of a nanohybrid built by grafting C60-fullerenes on carbon nanotubes (CNTs). The nonlinear optical limiting properties of the CNT-C60 complex were investigated at wavelengths where C60 does not absorb. We found that the nanohybrid had superior performances to those of CNTs and fullerenes, either taken individually or as a mixture. This enhanced optical limitation of the nanohybrid suggests not only cooperative but also synergistic effects between the two carbon forms. A mechanism involving higher excitonic states of the CNTs formed by Auger recombination of low energy excitons is proposed. 相似文献
35.
Zhanbing He Chang Seok Lee Jean-Luc Maurice Didier Pribat Paul Haghi-Ashtiani Costel Sorin Cojocaru 《Carbon》2011,49(14):4710-4718
Plasma-enhanced chemical vapor deposition, without a nickel-containing gaseous precursor, was used to synthesize continuous nickel (Ni) nanorods inside the hollow cavity of carbon nanofibers (CNFs), thus forming vertically aligned Ni/CNF core/shell structures. Scanning and transmission electron microscopic images indicate that the elongated Ni nanorods originate from the catalyst particles at the tips of the CNFs and that their formation is due to the effect of extrusion induced by the compressive force of the graphene layers during growth. Different from previous work, each vertically-aligned core/shell structure reported is totally isolated from its neighbors. Continuous Ni nanorods are found to separate into smaller ones with increasing growth time, which was ascribed to (i) the limited amount of Ni available in the tip of the CNF, (ii) the polycrystalline nature of the Ni nanorods and (iii) the combined effects of the compressive stresses on the side of the Ni nanorods and of the tensile stress along their axis. 相似文献
36.
Marie Hurtgen Antoine Debuigne Didier Gigmes Christine Jérôme Christophe Detrembleur 《Polymer》2012,53(20):4353-4358
The grafting mechanism of poly(vinyl acetate) macroradicals prepared by cobalt-mediated radical polymerization onto C60 is investigated. The experimental conditions directly impact the nature and stability of the PVAc/C60 adducts. In the presence of residual initiating radicals that can compete with PVAc° macroradicals for addition onto C60, mixtures of PVAc/C60 adducts having between one and eight polymer chains per C60 are formed. PVAc/C60 adducts prepared with low [PVAc]:[C60] ratios may contain weak C60–C60 bonds that further dissociate and account for the instability of the products. The formation of such dimers can be lessened by increasing the temperature from 30 °C to 100 °C. The temperature increase also allows a complete dissociation of the PVAc-Co dormant species into PVAc° macroradicals and an almost quantitative grafting of eight PVAc chains onto C60, leading to well-defined C60(PVAc)8 octa-adducts. These results might shed new light on the grafting onto C60 of macroradicals prepared by other CRP techniques. 相似文献
37.
Taxanes have been recognized as a family of very efficient anticancer drugs, but the formulation in use for the two main taxanes-Taxol for paclitaxel and Taxotere for docetaxel-have shown dramatic side effects. Whereas several new formulations for paclitaxel have recently appeared, such as Abraxane and others currently in various phases of clinical trials, there is no new formulation in clinical trials for the other main taxane, docetaxel, except BIND-014, a polymeric nanoparticle, which recently entered phase I clinical testing. Therefore, we review herein the state of the art and recent abundance in published results of academic approaches toward nanotechnology-based drug-delivery systems containing nanocarriers and targeting agents for docetaxel formulations. These efforts will certainly enrich the spectrum of docetaxel treatments in the near future. Taxotere's systemic toxicity, low water solubility, and other side effects are significant problems that must be overcome. To avoid the limitations of docetaxel in clinical use, researchers have developed efficient drug-delivery assemblies that consist of a nanocarrier, a targeting agent, and the drug. A wide variety of such engineered nanosystems have been shown to transport and eventually vectorize docetaxel more efficiently than Taxotere in vitro, in vivo, and in pre-clinical administration. Recent progress in drug vectorization has involved a combined therapy and diagnostic ("theranostic") approach in a single drug-delivery vector and could significantly improve the efficiency of such an anticancer drug as well as other drug types. 相似文献
38.
Emna Ouni Sbastien Pyr dit Ruys Marie-Madeleine Dolmans Gaëtan Herinckx Didier Vertommen Christiani A. Amorim 《International journal of molecular sciences》2020,21(23)
Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unraveling its composition can we leverage related tissue engineering and pharmacological efforts. Nevertheless, its unbiased proteomic identification still encounters some limitations mainly due to partial ECM enrichment by precipitation, sequential fractionation using unfriendly-mass spectrometry (MS) detergents, and resuspension with harsh reagents that need to be entirely removed prior to analysis. These methods can be technically challenging and labor-intensive, which affects the reproducibility of ECM identification and induces protein loss. Here, we present a simple new method applicable to tissue fragments of 10 mg and more. The technique has been validated on human ovarian tissue and involves a standardized procedure for sample processing with an MS-compatible detergent and combined centrifugation. This two-step protocol eliminates the need for laborious sample clarification and divides our samples into 2 fractions, soluble and insoluble, successively enriched with matrisome-associated (ECM-interacting) and core matrisome (structural ECM) proteins. 相似文献
39.
Stress Heterogeneity Effect on the Strength of Silicon Nitride 总被引:1,自引:0,他引:1
François Hild Elisabeth Amer Didier Marquis 《Journal of the American Ceramic Society》1992,75(3):700-702
The experiments reported in this paper demonstrate the causes of the failure of monolithic ceramics. The specimens are made of silicon nitride and tested at room temperature. The stress field within the specimen is different for each of four series of tests that have been conducted. Fractographic observations have also been made to identify the causes of the failures. A size effect analysis is performed. 相似文献
40.
The MX-80 bentonite is a reference material for studies in clay barriers. This paper aims to present an investigation of the behaviour of such a material during an infiltration test from the bottom in oedometric conditions. Using dual-energy γ radiation technique, time variations of moisture content are measured at various locations along the clay sample. The transport of water occurring in this experiment can be described by the classical diffusion equation in terms of the Boltzmann variable. A parameter of hydraulic diffusivity is obtained with the Matano's method.Two fluid transport mechanisms govern the phenomena: imbibition of the microporosity in the clay grains and capillary imbibition in the mesoporosity around the grains. The competition between these two mechanisms will be put into relief by modelling the distribution of the water between and inside the bentonite grains. A clogging behaviour of the mesopores during the imbibition process will allow to explain the surprising decrease in hydraulic diffusivity. 相似文献