A study of the synthesis,kinetics, and characterization of reactive graft copolymers of poly(vinyl imidazole) and cellulose for use as supports in enzyme immobilization and metal ion uptake

In continuation to our earlier work to use bioresource for developing alternate materials for use at the interface of biotechnology and polymer science, we have utilized pine needles as a renewable stock of cellulose to synthesize graft copolymers of vinyl imidazole. Kinetics of N‐VIm by simultaneous γ‐irradiation method has been investigated as a function of total dose, monomer concentration, and amount of water. Effect of water–methanol solvent composition on graft yields and polymerization kinetics has also been studied at the optimum grafting conditions of the total dose and monomer concentration. Effect of some additives such as ZnCl₂, Mohr salt, tetramethylethylene diamine, potassium persulfate, ammonium persulfate as grafting accelerators and promoters has also been studied. Graft copolymers have been characterized by elemental analysis, FTIR, and swelling studies. The graft copolymers have been used as supports for metal ions sorption, enzyme immobilization, and as potential biomimicking catalysts. Sorption behavior of Fe²⁺ ions and Cu²⁺ ions and the immobilization of bovine serum albumin and protease as a function of graft yield has been reported. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1522–1530, 2006     

Ferrofluid Lubrication of a Journal Bearing Considering Cavitation

Ferrohydrodynamic lubrication in journal bearings by considering cavitation boundary conditions is studied. It is assumed that the magnetization vector is not parallel to the magnetic field vector. Various bearing characteristics have been studied and it is seen that qualitative behavior of these characteristics remains similar to that in the case of non-ferromagnetic fluid. However, a significant quantitative enhancement of these characteristics is observed.     

Single- and multi-component adsorption of cadmium and zinc using activated carbon derived from bagasse--an agricultural waste

The use of low-cost activated carbon derived from bagasse, an agricultural waste material, has been investigated as a replacement for the current expensive methods of removing heavy metals from wastewater. With a view to find a suitable application of the material, activated carbon has been derived, characterized and utilized for the removal of cadmium and zinc. The uptake of cadmium was found to be slightly greater than that of zinc and the sorption capacity increases with increase in temperature. The adsorption studies were carried out both in single- and multi-component systems. Adsorption data on derived carbon follows both the Freundlich and Langmuir models. The data are better fitted by the Freundlich isotherm as compared to Langmuir in both the single- and multi-component systems. Isotherms have been used to obtain the thermodynamic parameters. The kinetics of adsorption depends on the adsorbate concentration and the physical and chemical characteristics of the adsorbent. Studies were conducted to delineate the effect of temperature, initial adsorbate concentration, particle size of the adsorbent and solid-to-liquid ratio. On the basis of these studies, various parameters such as mass transfer coefficient, effective diffusion coefficient, activation energy and entropy of activation were evaluated to establish the mechanisms. It was concluded that the adsorption occurs through a film diffusion mechanism at low as well as at higher concentrations.     

GPS: a constraint-based gene position procurement in chromosome for solving large-scale multiobjective multiple knapsack problems

The multiple knapsack problem (MKP) forms a base for resolving many real-life problems. This has also been considered with multiple objectives in genetic algorithms (GAs) for proving its efficiency. GAs use self-adaptability to effectively solve complex problems with constraints, but in certain cases, self-adaptability fails by converging toward an infeasible region. This pitfall can be resolved by using different existing repairing techniques; however, this cannot assure convergence toward attaining the optimal solution. To overcome this issue, gene position-based suppression (GPS) has been modeled and embedded as a new phase in a classical GA. This phase works on the genes of a newly generated individual after the recombination phase to retain the solution vector within its feasible region and to improve the solution vector to attain the optimal solution. Genes holding the highest expressibility are reserved into a subset, as the best genes identified from the current individuals by replacing the weaker genes from the subset. This subset is used by the next generated individual to improve the solution vector and to retain the best genes of the individuals. Each gene’s positional point and its genotype exposure for each region in an environment are used to fit the best unique genes. Further, suppression of expression in conflicting gene’s relies on the requirement toward the level of exposure in the environment or in eliminating the duplicate genes from the environment. TheMKP benchmark instances from the OR-library are taken for the experiment to test the new model. The outcome portrays that GPS in a classical GA is superior in most of the cases compared to the other existing repairing techniques.     

Benefits of optical system diversity for multiplexed image reconstruction

Algorithms that use optical system diversity to improve multiplexed image reconstruction from multiple low-resolution images are analyzed and demonstrated. Compared with systems using identical imagers, systems using additional lower-resolution imagers can have improved accuracy and computation. The diverse system is not sensitive to boundary conditions and can take full advantage of improvements that decrease noise and allow an increased number of bits per pixel to represent spatial information in a scene.     

Nanoparticle multilayers: surface modification of photosensitive drug microparticles for increased stability and in vitro bioavailability

The results of this study report the novel use of electrostatic layer-by-layer nanoassembly of biocompatible nanoparticulate TiO2 multilayers to coat irregular nifedipine (NF) microcrystals to increase the photostability of the drug when exposed to simulated sunlight and to increase the dissolution rate and possibly the bioavailability of the drug after oral administration. The photostability of NF microcrystals (35 microm) coated with multiple bilayers of positively charged PDDA and negatively charged nanosized TiO2 particles (20-25 nm) was measured when exposed to an illuminance of 12 W/m2 corresponding to a light dose of 30 k lux or 25 W/m2 corresponding to light dose of 60 k lux. The dissolution rate of nifedipine from the coated microcrystals was measured in simulated gastric fluid containing 0.05% w/v polysorbate 80. Coating with one TiO2 layer increased the shelf life of nifedipine by 30 hours independent of the intensity of the light exposure. With an increase in the number of TiO2 layers; the photostability of the drug was enhanced even more. A TiO2 monolayer decreased the contact angle by 20 degrees for water and 33 degrees for the dissolution medium as compared with uncoated NF surfaces. This increase in wettability due to a decrease in contact angle increased the dissolution rate of nifedipine microcrystals coated with 1 PDDA/TiO2 bilayer 13-fold after 10 minutes, 5-fold after 1 hour, and 2-fold after 12 hours when compared to uncoated microcrystals. It is assumed that TiO2 increased the photostability because the nanoparticulate multilayers acts as a potential filter protecting the drug from damaging light rays reaching the drug crystals. The dissolution rate was increased because the hydrophilic TiO2 nanoparticles increased the aqueous wettability of the drug crystals thereby preventing aggregation in the dissolution medium. This ensured that the maximum drug surface area was exposed to the dissolution medium.