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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
JA Koutcher AA Alfieri RL Stolfi ML Devitt JR Colofiore LD Nord DS Martin 《Canadian Metallurgical Quarterly》1993,53(15):3518-3523
The combination of N-(phosphonacetyl)-L-aspartate, 6-methylmercaptopurine, and 6-aminonicotinamide has been shown to be an effective antineoplastic regimen and also to enhance the effects of other chemotherapeutic agents. The mechanism of action of this combination of drugs is not known definitively, but one possible mechanism is biochemical modulation of energy metabolism and inhibition of production of tumor ATP. Tumor-bearing mice were treated with N-(phosphonacetyl)-L-aspartate, followed 17 h later by 6-methylmercaptopurine and 6-aminonicotinamide. 31P nuclear magnetic resonance spectroscopic studies demonstrated a significant depletion of high energy phosphates at 10 h post-6-methylmercaptopurine and 6-aminonicotinamide. The addition of radiation at this time was shown to induce a significantly longer tumor growth delay and a greater number of regressions (including durable complete regressions) than either chemotherapy or radiation alone. The combination of chemotherapy and radiation was found to be supra-additive compared to the antineoplastic effects of either modality administered separately, without a measurable increase in host toxicity. 相似文献
42.
43.
Algorithm for cosine transform of Toeplitz matrices 总被引:1,自引:0,他引:1
An algorithm for calculating the 2D cosine transform of a Toeplitz matrix is presented. The algorithm is based on the application of 1D cosine transforms. More specifically, four 1D cosine transforms of size N are needed to obtain the transform of a Toeplitz matrix of size N×N. This is an improvement over previously published algorithms. The algorithm is also simple and regular 相似文献
44.
A. Ureña J. M. Gomez De Salazar J. Quiñones S. Merino J. Martin 《Journal of Materials Science》1996,31(3):807-817
Diffusion bonds have been produced between sheets of an Al-Li-Cu-Mg-Zr alloy using aluminium-4% copper vapour deposited metallic interlayers. Microstructural changes occurred both in the parent alloy and in the bond interface after diffusion bonding cycles and post-bonding heat treatments were analysed. Different metallographic techniques (light microscopy, scanning and transmission electron microscopy) have been used. Diffusion bonding trials were carried out using the same alloy (AA8090), both in non-superplastic (T6) and superplastic conditions. Differences in their behaviours in relation to diffusion bonding were observed. 相似文献
45.
Site-specific natural isotope fractionation of hydrogen studied by deuterium NMR (SNIF-NMR) spectroscopy is a powerful source of information on hydrogen pathways occurring in biosyntheses in natural conditions. The potential of the carbon counterpart of this method has been investigated and compared. Three typical molecular species, ethanol, acetic acid, and vanillin, have been considered. Taking into account the requirements of quantitative 13C NMR, appropriate experimental procedures have been defined and the repeatability and reproducibility of the isotope ratio determinations have been checked in different conditions. It is shown that the carbon version of the SNIF-NMR method is capable of detecting small differences in the carbon-13 content of the ethyl fragment of ethanols from different botanical or synthetic origins. These results are in agreement with mass spectrometry determinations of the overall carbon isotope ratios. Deviations with respect to a statistical distribution of 13C have been detected in the case of acetic acid and vanillin. However, since the method is very sensitive to several kinds of systematic error, only a relative significance can be attached at present to the internal parameters directly accessible. Isotope dilution experiments have also been carried out in order to check the consistency of the results. In the present state of experimental accuracy, the 13C NMR method is of more limited potential than 2H SNIF-NMR spectroscopy. However it may provide complementary information. Moreover it is particularly efficient for detecting and quantifying adulterations that aim to mimic the overall carbon-13 content of a natural compound by adding a selectivity enriched species to a less expensive substrate from a different origin. 相似文献
46.
Bei der Model Driven Architecture (MDA) bilden Modelle die zentralen Elemente des Softwareentwicklungsprozesses. Ziel ist es, plattformspezifische Modelle möglichst automatisiert aus plattformunabhängigen Modellen abzuleiten. Dadurch soll der Aufwand der Softwareentwicklung verringert und die Adaptierung an neue Technologien erleichtert werden.*Vorschläge an Prof. Dr. Frank Puppe oder Dieter Steinbauer Alle „Aktuellen Schlagwörter“ seit 1988 finden Sie unter: www.ai-wuerzburg.de/as 相似文献
47.
48.
Martin E. Valdez H. Shibata Alan W. Cramb 《Metallurgical and Materials Transactions B》2006,37(6):959-965
The objective of this study is to determine the conditions under which the inclusions present in liquid steel can act as heterogeneous
nucleants for solidification. In order to study the factors that define the undercooling of a given metal/oxide couple, the
undercooling of a pure iron sessile droplet in contact with Al2O3, ZrO2, and MgO substrates was measured under controlled oxygen partial pressures by observing droplet recalescence. The results
showed that the undercooling of iron, in contact with a particular substrate, did not have a unique value, but was significantly
affected by the oxygen content on the gas phase. For oxygen partial pressures between 10−21 and 10−19, the undercooling of iron on ZrO2 substrates was stable and around 290 °C. In the same range of oxygen partial pressure, the undercooling of iron on MgO substrates
remained below 100 °C due to the low stability of this oxide. At lower oxygen contents, substrate decomposition might be the
cause for the observed drop in the undercooling of iron on ZrO2 substrates to below 100 °C. The undercooling also decreased for increasing oxygen content as verified when the gas was changed
from gettered Ar/Ar-H2 to CO/CO2 mixtures. The variation in undercooling was related to the wetting of the substrate by the liquid metal, where the deep undercooling
observed in the ZrO2 experiments occurred when the highest contact angle between the liquid metal and the substrate was achieved. 相似文献
49.
Xiaoming Zhou Martin Jacobsson Henk Uijterwaal Piet Van Mieghem 《International Journal of Communication Systems》2008,21(6):643-663
Although packet delay and loss are two important parameters of the Internet performance, to the best of our knowledge, the evolution of large‐scale IPv6 delay and loss performance has previously not been studied. In this paper, we analyze more than 600 end‐to‐end IPv6 paths between about 26 testboxes of RIPE Network Coordination Centre over two years, and compare the delay and loss performance over time with their IPv4 counterparts. We present and discuss the measurement methodologies and show that IPv6 paths have a higher delay and loss than their IPv4 counterparts. The main reason for the worse performance stems from IPv6‐in‐IPv4 tunnels rather than from native IPv6 paths and such tunnels are still widely used today. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
50.
Martin Meyer 《Scientometrics》2007,70(3):779-810
This contribution formulates a number of propositions about the emergence of novel nanoscience and nanotechnology (N&N). Seeking
to complement recent work that aims to define a research agenda and draws on general insights from the innovation literature,
this paper aims to synthesize knowledge from innovation-related studies of the N&N field. More specifically, it is suggested
that N&N is often misconstrued as either a field of technology or an area of (broadly) converging technologies while evidence
to date suggests rather that N&N be considered a set of inter-related and overlapping about not necessarily merging technologies.
The role of instrumentation in connecting the various N&N fields is underlined. Finally, the question is raised whether change
in N&N tends to be incremental rather than discontinuous, being the result of technological path-dependencies and lock-ins
in industry-typical search regimes that are only slowly giving way to more boundary-crossing activities. 相似文献