Low-Voltage digitally controlled fully differential current conveyor

Design and simulation of a digitally controlled CMOS fully differential current conveyor (DCFDCC) is presented. A novel current division network (CDN) is used to provide the digital control of the current gain between terminals X and Z of this DCFDCC. The proposed DCFDCC operates under low supply voltage of /spl plusmn/1.5 V. The realization of the DCFDCC using the new CDN is presented by two approaches. First approach has linearly proportional current gain with the digitally controlled parameter of the CDN, while the second approach exhibits current gain between terminals X and Z greater than, or equal to, one. Applications of the DCFDCC in realizing second order universal active filter and variable gain amplifier are given. PSPICE simulation confirms the performance of the proposed blocks and its applications.     

Growth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease

Impaired growth involving both height and weight accompanying sickle cell disease (SCD) poses diagnostic and therapeutic problems. We undertook this study to test the hypothesis that this impaired growth is associated with abnormalities of the growth hormone (GH)/insulin-like growth factor-I (IGF-I)/IGF binding protein-3 (IGFBP-3) axis in 21 children with SCD and that SCD is associated with GH resistance. Nine of 21 children with SCD had a defective GH response to both clonidine and glucagon provocation (peak < 10 micrograms/L); these children differed from the 12 others in having slower linear growth velocity (GV and GVSDS), lower circulating concentrations of IGF-I and IGFBP-3, and either partial or complete empty sellae in computed tomographic scans of the hypothalamic-pituitary area. In this group of patients with SCD, it appears that defective GH secretion and consequent low IGF-I production are the major etiological factors causing the slow growth. The two groups with SCD did not differ significantly in dietary intake, body mass index (BMI), midarm circumferences, skinfold thickness, serum albumin concentration, or intestinal absorption of D-xylose. A single injection of GH produced a smaller increase in circulating IGF-I in children with SCD with or without defective GH secretion versus 10 age-matched children with idiopathic short stature (ISS) and 11 children with isolated GH deficiency (GHD), suggesting partial GH resistance in the SCD group. The presence of defective GH secretion, decreased IGF-I synthesis, and partial resistance to GH in short children with SCD suggests that treatment with IGF-I may be superior to GH therapy for improving growth.     

Frequency-dependent activation energy of ac-conductivity in poly(4,4′-N,N-diiminosulphoxide diaminophenyl ether)

Summary The ac conductivity of Poly(4,4′-N,N-diiminosulphoxide diaminophenyl ether) was measured at the temperature range 300–355 K as a function of frequency (range 10 Hz to 100 KHz). The activation energy at each frequency was calculated using the Arrhenius relation. A mathematical formula was suggested to explain the dependence of the activation energy on the applied frequency. It was found that there is a good consistent between the experimental and the calculated value.     

Phase I Analysis of Individual Observations with Missing Data

The effect of the methods for handling missing values on the performance of Phase I multivariate control charts has not been investigated. In this paper, we discuss the effect of four imputation methods: mean substitution, regression, stochastic regression and the expectation maximization algorithm. Estimates of mean vector and variance covariance matrix from the treated data set are used to estimate the unknown parameters in the Hotelling's T² chart statistic. Based on a Monte Carlo simulation study, the performance of each of the four methods is investigated in terms of its ability to obtain the nominal in‐control and out‐of‐control overall probability of a signal. We consider three sample sizes, five levels of the percentage of missing values and three types of variable numbers. Our simulation results show that the stochastic regression method has the best overall performance among all the competing methods. Copyright © 2013 John Wiley & Sons, Ltd.     

Reliability estimation in a generalized life-model with applicationto the Burr-XII

Estimators of the reliability function in a GLM (generalized life model) are considered. The class of the GLM includes (among others) the Weibull, Pareto, Beta, Gompertz, and Rayleigh distribution. A proper general prior density and the predictive function for general class of distribution proposed by Al-Hussaini(1999) are used to obtain the exact estimate. Also, the Bayes estimates relative to symmetric loss function (quadratic loss), and asymmetric loss function (LINEX loss, and GE loss), are obtained. Comparisons are made between those estimators and the MLE applying to the Burr-XII model using the Bayes approximation due to Lindley. Monte Carlo simulation was used     

A three-unit standby redundant system with repair and preventive maintenance

This paper deals with the reliability of a renewable three-unit system under preventive maintenance activity. The Laplace transform of the reliability function and the mean lifetime of the system have been obtained under the assumption that the failure times, repair times, inspection times and maintenance times are random variables having different distributions. Some special cases also have been obtained.     

Heated fats. Part 3. Biological effect and effect of heating and tempering oils on fatty acid composition of liver,heart and serum lipids of rats

The study deals with the biological effect caused by changes in fats during heating. The study includes feeding experiments and extraction of serum, liver, and heart from the animals tested. The biological study reveals that animals fed heated oil showed retardation of growth, poor efficiencies, rough, greasy mottled coats, and shortned life span.     

Selenium and cadmium induced pulmonary functional impairment and cytotoxicity

Ovalbumin-sensitized (50 mg/kg, i.p.) male Hartley-guinea-pigs (550-610 g; n = 6) were treated 14 days later intratracheally with saline, cadmium (Cd 0.3 mg), selenium (Se 0.3 mg or 0.06 mg) or Se (0.06 mg) with Cd (0.3 mg). After 24 h, baseline dynamic-lung-compliance (Cdynl) and pulmonary-resistance (Rp), and percent change after ovalbumin-aerosol-challenge (10 mg/ml, 60 s) were assessed. Cadmium or Se (0.3 mg), Se (0.06 mg) and/or Cd (0.3 mg) decreased Cdynl (P < 0.05). Selenium (0.3 mg) increased Rp (P < 0.05). Ovalbumin-challenge decreased Cdynl and increased Rp in all groups. Analysis of bronchoalveolar-lavage-fluid (BALF) displayed increased activities of lactate-dehydrogenase (LDH), beta-glucuronidase (beta-G), alkaline-phosphatase (AP), and protein due to 0.3 mg Se, 0.3 mg Cd alone or with 0.06 mg Se (P < 0.05). Findings indicated that, 0.3 mg Se is more detrimental than 0.3 mg Cd to lung-dynamics despite a modest protection by 0.06 mg Se against Cd illustrated by an ameliorated Cdynl and lower protein in BALF.     

Behavioral and neurochemical effects of acute and repeated administration of triadimefon in the male rat

The effects of triadimefon (TDF) were examined in male Sprague-Dawley rats. In this study, the acute administration of TDF (100 mg/kg) was found to significantly increase locomotor activity and induce stereotyped behavior. Acute administration of TDF was also found to significantly increase dopamine (DA) and homovanillic acid (HVA) levels while the dihydroxyphenylacetic acid (DOPAC) level remained unchanged in both the nucleus accumbens (NA) and striatal (ST) tissues when compared to control. Furthermore, DOPAC:DA ratios were significantly reduced in both brain regions suggesting an increase in DA turn overrate. On the other hand, in animals receiving repeated TDF administration, only the HVA level was significantly increased in both the ST and NA. TDF neither competed for binding to D2, D3 or D4 DA receptors nor altered the Kd or the Bmax of [3H] SCH 23390 and [3H] spiperone recognition sites associated with striatal D1 and D2 receptors, respectively. Meanwhile, TDF competed with [3H] GBR 12935 for binding to DA transporter sites with strong affinity, but repeated treatment with TDF had no sustained or cumulative effect on the DA transporter system. These results clearly show that acute TDF-induced behavioral effects may not be via binding to DA receptors, but through the interaction with DA transporter binding sites. Also, TDF does not appear to produce cumulative effects in the parameters evaluated.