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31.
The presence of clearance in the kinematic pairs of mechanisms has a strong influence on the mechanism performances. Where positioning tasks are concerned, clearance can be considered as one of the most relevant error sources, since it affects both accuracy and repeatability. The development of predictive models then becomes relevant, suitable for assessing in advance the influence of clearance and for correcting unacceptable effects. Several deterministic techniques assessing the accuracy of clearance‐affected mechanisms have been proposed in the literature; these techniques require the development of kinetostatic models for clearance‐affected pairs. This paper presents a modeling for clearance‐affected prismatic pairs. Such a model determines the three‐dimensional displacement between the pairing elements in the prismatic pair, and relates it to the load acting on the pair. Since the displacement depends strongly on the actual pair design, the model is described in detail for a particular pair geometry; in principle, however, this approach could be used for any geometry. The proposed model may be implemented in kinematic, kinetostatic, or dynamic analyses as well, with the purpose of computing the influence of clearance on the position and orientation error of any link of a mechanism. © 2005 Wiley Periodicals, Inc. 相似文献
32.
A capacitive tactile sensor and a thermal sensor that can be combined into one compact device with both modalities are illustrated. The tactile sensing portion is composed of an 8 × 8 array of capacitive cells. By using as thermoresistors the rows' traces of the matrix of the capacitive tactile array sensor thermal sensing is obtained. This allows the detection of the gradient of the temperature. A prototype of the new sensor, which has been developed, is briefly illustrated and the so-obtained results are shortly discussed. On account of the simplicity and cheapness of the integrated sensor as well as its high linearity and sensitivity, it appears to be useful for the robots of future generations 相似文献
33.
Epidemiological studies show that populations consuming a predominantly plant-based Mediterranean-style diet exhibit lower
incidences of chronic diseases than those eating a northern European or North American diet. This observation has been attributed
to the greater consumption of fruits and vegetables and the lower consumption of animal products, particularly fat. Although
total fat intake in Mediterranean populations can be higher than in other regions (ca. 40% of calories), the greater proportion
is derived from olive oil and not animals. Increased olive oil consumption is implicated in a reduction in cardiovascular
disease, rheumatoid arthritis, and, to a lesser extent, a variety of cancers. Olive oil intake also has been shown to modulate
immune function, particularly the inflammatory processes associated with the immune system. Olive oil is a nonoxidative dietary
component, and the attenuation of the in-flammatory process it elicits could explain its beneficial effects on disease risk
since oxidative and inflammatory stresses appear to be underlying factors in the etiology of these diseases in man. The antioxidant
effects of olive oil are probably due to a combination of its high oleic acid content (low oxidation potential compared with
linoleic acid) and its content of a variety of plant antioxidants, particularly oleuropein, hydroxytyrosol, and tyrosol. It
is also possible that the high oleic acid content and a proportionate reduction in linoleic acid intake would allow a greater
conversion of α-linolenic acid (18∶3n−3) to longer-chain n−3 PUFA, which have characteristic health benefits. Adoption of
a Mediterranean diet could confer health benefits in high-risk populations. 相似文献
34.
A new algorithm for the retrieval of columnar water vapor content is presented. The proposed procedure computes the area of the H2O absorption centered about 940 nm to allow its integrated columnar abundance as well as its density at ground level to be assessed. The procedure utilizes the HITRAN 2000 database as the source of H2O cross-section spectra. Experimental results were derived from radiometrically calibrated hyperspectral images collected by the Airborne Visible-Infrared Imaging Spectrometer (AVIRIS) sensor over the Cuprite mining district in Nevada. Numerical simulations based on the MODTRAN 4 radiative transfer code were also employed for investigating the algorithm's performance. An additional empirical H2O retrieval procedure was tested by use of data gathered by the VIRS-200 imaging spectrometer. 相似文献
35.
Loredana Elena Nita Aurica P Chiriac Sossio Cimmino Clara Silvestre Donatella Duraccio Cornelia Vasile 《Polymer International》2008,57(2):342-349
BACKGROUND: The possibility to use β‐cyclodextrin as biodegradable tensioactive and an electromagnetic field in order to improve the kinetic parameters of radical emulsion polymerization is of interest. Thus, the influence of different surfactants—sodium lauryl sulfate (SLS) and β‐cyclodextrin (CD)—on the pathway of emulsion polymerization of methyl methacrylate (MMA) and emulsion copolymerization of MMA with 2,3‐epoxypropyl methacrylate (GMA) performed with or without the presence of a continuous electromagnetic field (MF) was studied. RESULTS: The presence of the MF leads to a considerable increase of the conversion during the first part of the reaction if the classic surfactant (SLS) is used. The reactions performed without MF and with CD exhibit a decrease of the conversion and of the polymerization rate as compared with the variants using SLS. The swelling rate and the maximum degree of swelling vary with the surfactant nature and with the reaction conditions and MF presence. Data from thermogravimetry and differential scanning calorimetry evidence the dependences between the polymer characteristics and the preparation conditions. CONCLUSION: This research underlines the coupling possibilities of the influence of a MF—growth of the reaction rate and conversion explained through radical pairs mechanism—with a combination of the ‘cage’ effect and ‘conformational control’ afforded by CD. The presence of MF and CD during the syntheses leads to an increase of Tg and an increase of PMMA and P(MMA‐co‐GMA) thermal stability. Copyright © 2007 Society of Chemical Industry 相似文献
36.
Benini L. Castelli G. Macii A. Macii E. Poncino M. Scarsi R. 《Very Large Scale Integration (VLSI) Systems, IEEE Transactions on》2001,9(5):630-640
For portable applications, long battery lifetime is the ultimate design goal. Therefore, the availability of battery and voltage converter models providing accurate estimates of battery lifetime is key for system-level low-power design frameworks. In this paper, we introduce a discrete-time model for the complete power supply subsystem that closely approximates the behavior of its circuit-level continuous-time counterpart. The model is abstract and efficient enough to enable event-driven simulation of digital systems described at a very high level of abstraction and that includes, among their components, also the power supply. The model gives the designer the possibility of estimating battery lifetime during system-level design exploration, as shown by the results we have collected on meaningful case studies. In addition, it is flexible and it can thus be employed for different battery chemistries 相似文献
37.
A Maternal High Fat Diet Has Long‐Lasting Effects on Skeletal Muscle Lipid and PLIN Protein Content in Rat Offspring at Young Adulthood
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Rebecca E. K. MacPherson Laura M. Castelli Paula M. Miotto Scott Frendo‐Cumbo Amanda Milburn Brian D. Roy Paul J. LeBlanc Wendy E. Ward Sandra J. Peters 《Lipids》2015,50(2):205-217
A maternal high fat diet (HFD) can have adverse effects on skeletal muscle development. Skeletal muscle PLIN proteins (PLIN2, 3 and 5) are thought to play critical roles in lipid metabolism, however effects of HFD on PLIN and lipases (HSL, ATGL, CGI‐58) in mothers as well as their offspring have yet to be investigated. The primary objective of this study was to determine whether maternal HFD would influence skeletal muscle lipase and PLIN protein content in offspring at weaning (19d) and young adulthood (3mo). Female rats (28d old, n = 9/group) were fed control (CON, AIN93G, 7 % soybean oil) or HFD (AIN93G, 20 % lard) for 10 weeks prior to mating and throughout pregnancy and lactation. All offspring were weaned to CON [n = 18/group, 1 female and 1 male pup per litter were studied at weaning (19d) and 3mo of age]. There was no effect of sex for the main outcomes measured in plantaris, therefore male and female data was combined. Maternal HFD resulted in higher triacylglycerol content in pups at 3mo (p < 0.05), as well as in the dams (p = 0.015). Maternal HFD resulted in higher PLIN5 content in pups at weaning and 3mo (p = 0.05). PLIN2 and PLIN5 content decreased at 3mo versus weaning (p < 0.001). HFD dams had a higher PLIN3 content (p = 0.016). Diet had no effect on ATGL, CGI‐58, or HSL content. In conclusion, exposure to a maternal HFD resulted in higher skeletal muscle lipid and PLIN5 content in plantaris of offspring through to young adulthood. 相似文献
38.
Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains
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Dr. Bruno Tasso Dr. Federica Novelli Dr. Michele Tonelli Dr. Anna Barteselli Dr. Nicoletta Basilico Dr. Silvia Parapini Prof. Donatella Taramelli Prof. Anna Sparatore Prof. Fabio Sparatore 《ChemMedChem》2015,10(9):1570-1583
Chloroquine is commonly used in the treatment and prevention of malaria, but Plasmodium falciparum, the main species responsible for malaria‐related deaths, has developed resistance against this drug. Twenty‐seven novel chloroquine (CQ) analogues characterized by a side chain terminated with a bulky basic head group, i.e., octahydro‐2H‐quinolizine and 1,2,3,4,5,6‐hexahydro‐1,5‐methano‐8H‐pyrido[1,2‐a][1,5]diazocin‐8‐one, were synthesized and tested for activity against D‐10 (CQ‐susceptible) and W‐2 (CQ‐resistant) strains of P. falciparum. Most compounds were found to be active against both strains with nanomolar or sub‐micromolar IC50 values. Eleven compounds were found to be 2.7‐ to 13.4‐fold more potent than CQ against the W‐2 strain; among them, four cytisine derivatives appear to be of particular interest, as they combine high potency with low cytotoxicity against two human cell lines (HMEC‐1 and HepG2) along with easier synthetic accessibility. Replacement of the 4‐NH group with a sulfur bridge maintained antiplasmodial activity at a lower level, but produced an improvement in the resistance factor. These compounds warrant further investigation as potential drugs for use in the fight against malaria. 相似文献
39.
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells
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40.
Giuseppina Adiletta Loredana Liguori Donatella Albanese Paola Russo Marisa Di Matteo Alessio Crescitelli 《Food and Bioprocess Technology》2017,10(9):1631-1641
A preliminary characterization of two new soft-seeded pomegranate varieties (MR-100® and KINGDOM®) based on their main physico-chemical and nutritional parameters was reported. The two varieties showed significant differences (p ≤ 0.05) in polyphenols, anthocyanins and antioxidant activity. Kingdom pomegranate had higher polyphenols (2524.73 mg GAE/L), anthocyanins (752.49 mg C3gE/L) and antioxidant activity (EC50 13.58 μL/mL) than MR-100 (1792.74 mg GAE/L, 141.29 mg C3gE/L and EC50 47.53 μL/mL, respectively). Moreover, minimally processed arils of the two varieties were packaged in semipermeable and micro-perforated film at 5 °C, and the quality changes that occurred during storage condition (15 days) were investigated. During storage, Kingdom arils exhibited a better performance in terms of antioxidant activity, polyphenols and anthocyanin content with respect to MR-100. Furthermore, the packaging systems did not affect the estimated quality parameters for both varieties. Based on the sensory evaluation and microbial counts, both aril varieties reached, at 15-day storage, suitable values for commercial purpose. 相似文献