β-Hexachlorocyclohexane Drives Carcinogenesis in the Human Normal Bronchial Epithelium Cell Line BEAS-2B

Organochlorine pesticides constitute the majority of the total environmental pollutants, and a wide range of compounds have been found to be carcinogenic to humans. Among all, growing interest has been focused on β-hexachlorocyclohexane (β-HCH), virtually the most hazardous and, at the same time, the most poorly investigated member of the hexachlorocyclohexane family. Considering the multifaceted biochemical activities of β-HCH, already established in our previous studies, the aim of this work is to assess whether β-HCH could also trigger cellular malignant transformation toward cancer development. For this purpose, experiments were performed on the human normal bronchial epithelium cell line BEAS-2B exposed to 10 µM β-HCH. The obtained results strongly support the carcinogenic potential of β-HCH, which is achieved through both non-genotoxic (activation of oncogenic signaling pathways and proliferative activity) and indirect genotoxic (ROS production and DNA damage) mechanisms that significantly affect cellular macroscopic characteristics and functions such as cell morphology, cell cycle profile, and apoptosis. Taking all these elements into account, the presented study provides important elements to further characterize β-HCH, which appears to be a full-fledged carcinogenic agent.     

威尼斯IUAV建筑学院工作坊主题设计

2005年夏天，我们事务所应邀参加在威尼斯IUAV建筑学院举办的为期三周的工作坊。     

The Darrieus wind turbine: Proposal for a new performance prediction model based on CFD

This paper presents a CFD model for the evaluation of energy performance and aerodynamic forces acting on a straight-bladed vertical-axis Darrieus wind turbine. The basic principles which are currently applied to BE-M theory for rotor performance prediction are transferred to the CFD code, allowing the correlation between flow geometric characteristics (such as blade angles of attack) and dynamic quantities (such as rotor torque and blade tangential and normal forces). The model is proposed as a powerful design and optimization tool for the development of new rotor architectures for which test data is not available.After describing and validating the computational model against experimental data, a full campaign of simulation is proposed for a classical NACA 0021 three-bladed rotor.Flow field characteristics are investigated for several values of tip speed ratio, allowing a comparison among rotor operation at optimum and lower C_p values, so that a better understanding of vertical-axis wind turbines basic physics is obtained.     

Lichens on asbestos-cement roofs: bioweathering and biocovering effects

Asbestos-cement roofs, the most widespread sources of airborne, toxic and carcinogenic asbestos fibres, are often colonized by lichens. Since these latter are physical and chemical weathering agents, they have been often considered as significant responsible of disaggregation processes increasing fibre dispersion. Consequently, official guidelines for the management of asbestos often suggest their removal. Weathering and/or covering effects of lichens on asbestos-cement, however, have never been deeply investigated and available procedures to evaluate asbestos-cement aging do not take the biological colonization into account. In this study we show that a 25% lichen cover modifies physical and chemical properties of asbestos-cement sheets containing chrysotile and crocidolite fibres. By innovatively coupling pull up tests and image analysis of linear structures, we show that fibre loss is significantly lower ( approximately 30%) where lichens develop and offer a physical barrier to the fibre detachment. Below the most covering lichens (Acarospora cervina, Candelariella ssp.), chrysotile and crocidolite undergo a partial incongruent dissolution, which in laboratory assays generally determined a reduction of their surface reactivity. Because of their biocovering and bioweathering effects, lichens on asbestos-cement play a role which differs from the current public opinion and the assumptions of some official regulations, acting as effective spontaneous bioattenuation agents.     

Experimental Observations of Flow and Bed Processes in Large-Amplitude Meandering Flume

Meanders of large amplitude often exhibit asymmetric planform shape or subsidiary bends. The present work is aimed at improving on understanding of the morphodynamic phenomena affecting the bed evolution of large amplitude meandering channels. Attention is focused on the development of the steady point bar-pool configuration and of the superimposed large-scale migrating bed forms; of particular interest is the role of the changing channel curvature and bed topography variation on flow pattern. A series of experiments was carried out in a sine-generated large-amplitude meandering flume, for two values of width-to-depth ratio. Maps documenting the bed topography and the flow pattern along the meandering bends are reported. Two point bars per bend were observed and seem to be part of a series of damped oscillations developing in response to the changing channel curvature. In response to the bed deformation, the maximum flow velocity moves at the outer bank at the entrance of the bend.     

Solar spectral irradiometer for validation of remotely sensed hyperspectral data

A new solar spectral irradiometer that operates in the visible and near-infrared spectral ranges has been developed. This instrument takes advantage of a new concept optical head that collects the light that impinges on a hemispheric surface, thus improving the instrument angular response with respect to traditional devices. The technical characteristics of the instrument are investigated and detailed, and its radiometric calibration, performed by means of a Langley-like method, is discussed. A new simplified theoretical model that accounts for the diffuse irradiance observed in an optically thin plane-parallel atmosphere has been developed to improve the fit of the irradiance diurnal evolution. An alternative polynomial parametric representation of monochromatic diffuse irradiance evolution has been attempted, but satisfactory results were not obtained from the fitting of experimental data. The new instrument could be useful to carry out remote-sensing validation campaigns.     

OpenDLib: an infrastructure for new generation digital libraries

This paper presents OpenDLib, a digital library infrastructure that provides capabilities for new-generation digital libraries. In particular, the paper introduces a document model that can be used to represent a wide variety of document types and describes the open architectural infrastructure that allows for the expansion of the digital library through the dynamic plugin of new services.     

Some acoustic features of nasal and nasalized vowels: a target for vowel nasalization

In order to characterize acoustic properties of nasal and nasalized vowels, these sounds will be considered as a dynamic trend from an oral configuration toward an [n]-like configuration. The latter can be viewed as a target for vowel nasalization. This target corresponds to the pharyngonasal tract and it can be modeled, with some simplifications, by a single tract without any parallel paths. Thus the first two resonance frequencies (at about 300 and 1000 Hz) characterize this target well. A series of measurements has been carried out in order to describe the acoustic characteristics of the target. Measured transfer functions confirm the resonator nature of the low-frequency peak. The introduction of such a target allows the conception of the nasal vowels as a trend beginning with a simple configuration, which is terminated in the same manner, so allowing the complex nasal phenomena to be bounded. A complete study of pole-zero evolutions for the nasalization of the 11 French vowels is presented. It allows the proposition of a common strategy for the nasalization of all vowels, so a true nasal vowel can be placed in this nasalization frame. The measured transfer functions for several French nasal vowels are also given.