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51.
Ralquí Garcia Gustavo Gedler Alejandro Izquierdo Douglas Rodriguez 《Petroleum Science and Technology》1994,12(7):983-1001
This paper describes the statistical analysis of data on coke formation (measured by microcarbon residue) in five resids, as a function of compound classes, in order to identify variables wiih a significant effect on the former. In this sense, the SAS VARCLUS and Principal Component Analysis were used. The analysis carried out leads to a lineal combination of the H/C ratio, vanadium and nitrogen content as a model to explain coke yield, under non-catalytic conditions, as determined by MCR. Of all these factors, the H/C ratio has the most important contribution. 相似文献
52.
Lyndsay A. Cartwright Sue Hayes Douglas C. Tozer Dan Clayton Mary-Ann Burns Dena Lewis Noah Gaetz Namrata Shrestha 《Journal of Great Lakes research》2021,47(2):273-282
Beneficial use impairments (BUIs) under the Great Lakes Water Quality Agreement identify environmental issues requiring remedial action within the Great Lakes Areas of Concern (AOCs). We conducted this study to support the assessment of the wildlife component of BUI 3: degradation of fish and wildlife populations. We compared bird and amphibian (frogs and toads) data from the Toronto and Region Conservation Authority’s Terrestrial Long-term Monitoring Program in the Toronto and Region AOC to an adjacent, but otherwise similar, reference watershed, Duffins Creek. Twelve of 13 targets were met within the AOC for forest bird, wetland bird, meadow bird and amphibian populations based on averages of mean annual values at sites within the AOC that were within two standard deviations of averages at sites in the Duffins Creek reference watershed between 2008 and 2017. Even though wildlife populations within the AOC were within the normal range of variability expected from a reference watershed, they were often at lower levels than within the Duffins Creek reference watershed. In addition, forest bird and amphibian populations were negatively affected by urbanization within the AOC and meadow bird indices declined. We conclude that while wildlife populations within the AOC currently meet targets for BUI 3, they continue to be negatively impacted by numerous stressors that are primarily related to past and ongoing urbanization. Thus, continued restoration of wildlife habitat and protection of existing habitat within the AOC is highly recommended. 相似文献
53.
Douglas A. Watkinson Colin Charles Eva C. Enders 《Journal of Great Lakes research》2021,47(3):583-591
Common carp feeding and spawning behaviours negatively impact the functioning of marsh ecosystems. In the Netley-Libau Marsh, situated on the southern end of Lake Winnipeg, water level regulations, nonpoint source nutrient pollution, and the non-native common carp are thought to be the main contributors to the degradation of the marsh habitat. Using acoustic telemetry, we analysed the movement rate, frequency and timing of suspected spawning migrations, spatial ecology, and aggregation of common carp in the Lake Winnipeg drainage over a three year time period. Common carp moved the farthest during the open water period when water temperature was >5 °C. Their annual migration into Netley-Libau Marsh was correlated to ordinal date. Common carp left the marsh in late spring/early summer, presumably feeding in Lake Winnipeg, before moving to overwintering sites situated in Traverse Bay and Lake Winnipeg, where they arrived typically by October and formed aggregations. These findings will inform habitat and fisheries managers in the effort to undertake evidence-based management actions. The predictability of the movements and the tendency for common carp to aggregate indicates that exclusion techniques and commercial fishing may represent viable management solutions. 相似文献
54.
James E. Corter J. Douglas Carroll 《Annals of Mathematics and Artificial Intelligence》1990,2(1-4):77-92
Theknowledge transfer problem in artificial intelligence consists of finding effective ways to elicit information from a human expert and represent it in a form suitable for use by an expert system. One approach to formalizing and guiding this knowledge transfer process for certain types of expert systems is to use psychometric scaling methods to analyze data on how the human expert compares or groups solutions. For example, Butler and Corter [1] obtained judgments of thesubstitutability of solutions from an expert, then analyzed the resulting data via techniques for fitting trees and extended trees [2]. The expert's interpretation of certain aspects of the solutions were directly encoded as production rules, allowing rapid prototyping. In this paper we consider the problem of combining information from multiple experts. We propose the use of three-way or individual differences multidimensional scaling, tree-fitting, and unfolding models to analyze two types of data obtainable from the multiple experts: judgments of the substitutability of pairs of solutions, and judgments of the appropriateness of specific solutions to specific problems. An application is described in which substitutability data were obtained from three experts and analyzed using the SINDSCAL program [3] for three-way multidimensional scaling [4]. 相似文献
55.
Results of Schlipf (J Comput Syst Sci 51:64?C86, 1995) and Fitting (Theor Comput Sci 278:25?C51, 2001) show that the well-founded semantics of a finite predicate logic program can be quite complex. In this paper, we show that there is a close connection between the construction of the perfect kernel of a $\Pi^0_1$ class via the iteration of the Cantor?CBendixson derivative through the ordinals and the construction of the well-founded semantics for finite predicate logic programs via Van Gelder??s alternating fixpoint construction. This connection allows us to transfer known complexity results for the perfect kernel of $\Pi^0_1$ classes to give new complexity results for various questions about the well-founded semantics ${\mathit{wfs}}(P)$ of a finite predicate logic program P. 相似文献
56.
Douglas Cenzer Ali Dashti Ferit Toska Sebastian Wyman 《Theory of Computing Systems》2012,51(3):352-371
We investigate the computability of countable subshifts in one dimension, and their members. Subshifts of Cantor?CBendixson rank two contain only eventually periodic elements. Any rank two subshift in 2? is decidable. Subshifts of rank three may contain members of arbitrary Turing degree. In contrast, effectively closed ( $\Pi^{0}_{1}$ ) subshifts of rank three contain only computable elements, but $\Pi^{0}_{1}$ subshifts of rank four may contain members of arbitrary $\Delta^{0}_{2}$ degree. There is no subshift of rank ??+1. 相似文献
57.
The last decade has placed the superiority of graphical user interfaces over traditional text-based approaches beyond dispute. In almost all contexts, users have found graphical interfaces easier to learn, faster to use, and less error-prone. However, it has been shown that the creation of powerful graphical interfaces takes up to 80% of the time required to develop an application. In our work, we seek to extend the benefits of graphical interaction to the next layer of computer user—the interface designer. Our work in this area is distinguished from other efforts by two important differences. First, while other efforts focus primarily on the design of standard user interfaces, our approach emphasizes the creation of unique and innovative interfaces by supporting, among other things, arbitrary user-designed graphical representations, direct specification of animation, and digitized sound. Second, our goal is to cater to the nonprogrammer. Thus, we address a challenging trade-off: maximizing power and flexibility in an extremely simple environment. We explore the utility of the prototype object-oriented paradigm, a high-level userinterface language, and a direct-manipulation programming environment in this context. 相似文献
58.
Rodrigo F. Ortiz-Meoz Liping Wang Rosalie Matico Anna Rutkowska-Klute Martha De la Rosa Sabrina Bedard Robert Midgett Katrin Strohmer Douglas Thomson Cunyu Zhang Makda Mebrahtu Jeffrey Guss Rachel Totoritis Thomas Consler Nino Campobasso David Taylor Tia Lewis Kurt Weaver Marcel Muelbaier John Seal Richard Dunham Wieslaw Kazmierski David Favre Giovanna Bergamini Lisa Shewchuk Alan Rendina Guofeng Zhang 《Chembiochem : a European journal of chemical biology》2021,22(3):516-522
Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As it is an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 activity is currently being pursued as a potential therapeutic tool for the treatment of cancer and other disease states. As such, a detailed understanding of the mechanism of action of IDO1 inhibitors with various mechanisms of inhibition is of great interest. Comparison of an apo-form-binding IDO1 inhibitor (GSK5628) to the heme-coordinating compound, epacadostat (Incyte), allows us to explore the details of the apo-binding inhibition of IDO1. Herein, we demonstrate that GSK5628 inhibits IDO1 by competing with heme for binding to a heme-free conformation of the enzyme (apo-IDO1), whereas epacadostat coordinates its binding with the iron atom of the IDO1 heme cofactor. Comparison of these two compounds in cellular systems reveals a long-lasting inhibitory effect of GSK5628, previously undescribed for other known IDO1 inhibitors. Detailed characterization of this apo-binding mechanism for IDO1 inhibition might help design superior inhibitors or could confer a unique competitive advantage over other IDO1 inhibitors vis-à-vis specificity and pharmacokinetic parameters. 相似文献
59.
Jogender Singh Douglas E. Wolfe 《Journal of Materials Engineering and Performance》2005,14(4):448-459
Fabrication of cost-effective, nano-grained net-shaped components has brought considerable interest to Department of Defense,
National Aeronautics and Space Administration, and Department of Energy. The objective of this paper is to demonstrate the
versatility of electron beam-physical vapor deposition (EB-PVD) technology in engineering new nanostructured materials with
controlled microstructure and microchemistry in the form of coatings and net-shaped components for many applications including
the space, turbine, optical, biomedical, and auto industries. Coatings are often applied on components to extent their performance
and life under severe environmental conditions including thermal, corrosion, wear, and oxidation. Performance and properties
of the coatings depend upon their composition, microstructure, and deposition condition. Simultaneous co-evaporation of multiple
ingots of different compositions in the high energy EB-PVD chamber has brought considerable interest in the architecture of
functional graded coatings, nano-laminated coatings, and design of new structural materials that could not be produced economically
by conventional methods. In addition, high evaporation and condensate rates allowed fabricating precision net-shaped components
with nanograined microstructure for various applications. Using EB-PVD, nano-grained rhenium (Re) coatings and net-shaped
components with tailored microstructure and properties were fabricated in the form of tubes, plates, and Re-coated spherical
graphite cores. This paper will also present the results of various metallic and ceramic coatings including chromium, titanium
carbide (TiC), titanium diboride (TiB2), hafnium nitride (HfN), titanium-boron-carbonitride (TiBCN), and partially yttria stabilized zirconia (YSZ) TBC coatings
deposited by EB-PVD for various applications.
This paper was presented at the International Symposium on Manufacturing, Properties, and Applications of Nanocrystalline
Materials sponsored by the ASM International Nanotechnology Task Force and TMS Powder Materials Committee, October 18–20,
2004, Columbus, OH. 相似文献
60.
Assessment of contaminant releases during utilization of used oils is essential for the determination of environmental acceptability. These paper reports the results of the study examining a toxic metal leachability from used engine oil and sludge samples employing leaching test (TCLP). The leaching test indicated that lead in oil samples exceeded 5-ppm concentration level what qualified them as a toxic waste. The samples of contaminated sludge were found to contain high concentration of total lead, barium and chromium, but the leaching test showed concentration below regulatory limit. The total content of benzene, ethylbenzene, toluene, and xylenes (BETX), and naphthalene in used oil and sludge samples was also determined and was found not to be a significant factor to contamination. 相似文献