Vertebral artery trauma

The developmental consequences of paternal exposure to acrylamide (50 mg/kg i.p. for 5 days) were assessed in preimplantation embryos. There was a significant increase in the proportion of morphologically abnormal embryos after postmeiotic treatment during spermatogenesis (88.7% vs. 14.8% in control). Abnormal embryos had an average of 1.8 +/- 3.5 cells and > 80% had at least one fragmented nucleus. In addition, morphologically normal embryos were significantly delayed (34.3 +/- 12.8 cells per embryo vs. 57.6 +/- 15.7 in control, P < 0.001). Acrylamide caused 10- and 20-fold increases in frequencies of cells with micronuclei (MN) in morphologically normal and abnormal embryos, respectively (41 and 93 MN per 1,000 cells). Both centromere-negative (MN-) and centromere-positive (MN+) were induced. Nuclei of abnormal embryos were significantly larger (900 microm2 vs. 250 microm2) than controls. In addition, MN of abnormal embryos were larger than those of normal embryos (21.2 microm2 vs. 6.5 microm2, P < 0.01). Among control embryos, MN+ were significantly larger than MN- (P < 0.05). These findings suggest that the preimplantation embryo is a sensitive indicator of paternally transmitted effects on early development. Multiple mechanisms appear to be involved, including cytogenetic damage, proliferation arrest/delay, and fertilization failure. Future studies are needed to establish how induced cytological defects in preimplantation embryos contribute to birth defects and other postimplantation abnormalities.     

Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study

BACKGROUND AND PURPOSE: We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores. METHODS: The relationship between age, education, ApoE genotype, MRI examination of the brain, subclinical and clinical cardiovascular disease, and low (<80) score on the Modified Mini-Mental State Examination (3MSE, as modified by Teng and Chui) was evaluated for 3469 black and white participants in the Cardiovascular Health Study (CHS) in years 5 and 6 of the study. The participants were followed for up to 3 years. RESULTS: The prevalence of scores <80 in years 5 and 6 of the CHS was 8.2% for participants without and 20.4% for those with prior history of stroke. Age, race, and education were important determinants of low 3MSE scores. The prevalence of ApoE-4 (odds ratio [OR], 1.6 [1.1 to 2.1]) was directly related to scores <80, as was high ventricular volume (OR, 1.6 [1.2 to 2.3]), high white matter grade (OR, 1.4 [1.1 to 1.9]), and infarctlike lesions (OR, 1.6 [1.2 to 2.1]) on the MRI in the multivariate analysis. A five-point or greater decline in scores over up to 3 years was more often observed for participants with low 3MSE scores at year 5, at older ages, with lower education, and experiencing incident stroke (OR, 3.6 [1.2 to 10.6]), ApoE-4 genotype (OR, 1.8 [1.4 to 2.3]), and with MRI findings of high ventricular volume (OR, 2.0 [1.5 to 2.7]), and infarctlike lesions (OR, 1.2 [0.9 to 1.5]). CONCLUSIONS: These results demonstrate that vascular changes on MRI, measures of brain atrophy, ApoE-4, and age, education, and race are associated with low cognitive scores among older individuals. The MRI of the brain provides valuable information related to cognitive tests and decline over time. The potential exists for using MRI measurements to identify high-risk individuals for dementia and to test potential interventions to reduce the risk of dementia.     

The effects of metformin on glycemic control and serum lipids in insulin-treated NIDDM patients with suboptimal metabolic control

The edentulous ridge expansion has been introduced in recent years to reestablish an appropriate alveolar ridge width. This technique consists of the placement of implants in the space formed after the dislocation of the buccal plate in a labial direction. In guided bone regeneration, the quantity of bone regenerated under the membranes has been demonstrated to be directly related to the amount of the space under the membranes. This space can diminish as a result of membrane collapse. To avoid this problem, a new technique of edentulous ridge expansion, which involved the use of a titanium mesh barrier to protect the regenerating tissues and to achieve a rigid fixation of the bone segments, was used in association with autologous bone in 25 patients. At second-stage surgery in all patients, it was possible to see tissue, under the mesh, that had the macroscopic characteristics of mature bone and was superficially covered by a thin soft tissue layer. The microscopic examination showed that all autologous bone particles were embedded in newly formed bone. The use of a rigid mesh can assist bone regeneration in non-space-making defects, since it probably does not interfere with the blood flow to the underlying tissues because of the presence of microholes within the mesh.     

Balance retraining in a hemiparetic patient using center of gravity biofeedback: a single-case study

A single-subject experimental design was used to evaluate the effects of center of gravity biofeedback on retraining balance control in a 72-yr.-old male hemiparetic patient. For both assessment and training the subject stood on dual force-plates enclosed on three sides by a visual surround. A 4-wk. training period consisted of subject-initiated shifts in body weight to control movement of a real-time computer display of the subject's center of gravity. A Sensory Organization Test and evaluation of weight distribution indicated that biofeedback retraining positively affected balance control during dynamic conditions and when the ground support moved forward.     

Impact of horizontal and vertical heterogeneities on retrievals using multiangle microwave brightness temperature data

This paper investigates the impact of heterogeneity at the land surface on geophysical parameters retrieved from multiangle microwave brightness temperature data, such as would be obtained from the Soil Moisture and Ocean Salinity (SMOS) mission. Synthetic brightness temperature data were created using the Common Land (land surface) Model, coupled with a microwave emission model and set within the framework of the North American Land Data Assimilation System (NLDAS). Soil moisture, vegetation optical depth, and effective physical temperature were retrieved using a multiobjective calibration routine similar to the proposed SMOS retrieval algorithm for a typical on-axis range of look angles. The impact of heterogeneity both in the near-surface profiles of soil moisture and temperature and in the land cover on the accuracy of the retrievals was examined. There are significant errors in the retrieved parameters over regions with steep gradients in the near-surface soil moisture profile. These errors are approximately proportional to the difference in the soil water content between the top (at 0.7 cm) and second layer (at 2.7 cm) of the land surface model. The errors resulting from heterogeneity in the land cover are smaller and increase nonlinearly with increasing land-surface heterogeneity (represented by the standard deviation of the optical depth within the pixel). The most likely use of retrieved soil moisture is through assimilation into an LDAS for improved initiation of weather and climate models. Given that information on the soil moisture profile is already available within the LDAS, the error in the retrieved soil moisture as a result of the near-surface profile can be corrected for. The potential errors as a result of land-surface heterogeneity can also be assessed for use in the assimilation process.     

Current on a long, thin wire in a chiral medium

The propagation of current on a thin, straight wire in an infinite chiral medium is examined by solution of the integral equation for an infinite wire and also from the moment-method solution for a long wire of finite length. The current on the infinite wire is shown to consist of three components: a discrete mode that decays exponentially and two continuous-spectrum components from branch cuts from the two chiral wavenumbers. The integral equation for a finite wire in the chiral medium is solved by the method of moments using a modified version of the numerical electromagnetics code (NEC). The moment-method solution is shown to be in close agreement with the modal solution for the infinite wire, providing validation for the numerical treatment     

Analysis of multilayered dielectric waveguides: variationaltreatment

A fast and near exact modal analysis is presented to obtain the propagation constants and electric field profiles for dielectric multilayered channel (rib) waveguides. Calculations are performed for a particular channel configuration and found to be in excellent agreement with those obtained using the finite difference method