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91.
Thyroid carcinoma after high-dose external radiotherapy for Hodgkin's disease: report of three cases
IR McDougall CN Coleman JS Burke W Saunders HS Kaplan 《Canadian Metallurgical Quarterly》1980,45(8):2056-2060
Three patients (two female and one male), who had received mantle irradiation for Hodgkin's disease eight, ten, and twelve years previously, developed papillary thyroid carcinoma. The radiation doses to the necks overlying the site of thyroid cancers were 3000, 4000, and 4100 rads, respectively. It has been stated that there is no risk of developing thyroid cancer with such high doses of external irradiation but apparently this complication will be encountered in a small number of patients. 相似文献
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Rhodes FM McDougall S Burke CR Verkerk GA Macmillan KL 《Journal of dairy science》2003,86(6):1876-1894
Cows with an extended interval from calving to first ovulation (PPI) have increased intervals from calving to conception and are more likely to be culled compared with cows with a short PPI. In year-round calving dairy herds, between 11 and 38% of cows are reported as anestrus by 50 or 60 d after calving. In seasonally calving dairy herds, between 13 and 48% of cows are diagnosed as anovulatory anestrus at the start of the breeding period. Ovulation and estrus after calving are delayed when the positive feedback effects of estradiol on release of LH from the pituitary, and circulating concentrations of metabolic hormones such as insulin and insulin-like growth factor-I, are reduced by a variety of environmental factors. The main factors are limited energy intake, lower body reserves, increased partitioning of energy to milk production, suckling, and peripartum disease. Treatment options for cows with an extended PPI include hormonal and management strategies. Hormonal treatments that include a period of progesterone supplementation result in the majority of treated animals displaying estrus with a subsequent luteal phase of normal duration and improved pregnancy rates compared with untreated controls. Hormonal interventions also tend to have more predictable outcomes compared with management changes, such as manipulating body condition or dietary intakes after calving, and usually have some estrous synchronization effect, thus facilitating the use of artificial insemination. However, responses to any treatment are variable and are related to those factors that influence duration of the PPI, such as body condition and parity. 相似文献
94.
A monolithic capillary electrophoresis system with integrated on-chip fluorescence detector has been microfabricated on a silicon substrate. Photodiodes in the silicon substrate measure fluorescence emitted from eluting molecules. The device incorporates an on-chip thin-film interference filter that prevents excitation light from inhibiting the fluorescence detection. A transparent AZO conducting ground plane is also used to prevent the high electric fields used for the separation from interfering with the photodiode response. Separations of DNA restriction fragments have been performed in these devices with femtogram detection limits using SYBR Green I intercalating dye. 相似文献
95.
A rapid and highly sensitive method for the detection of formaldehyde utilizing selected ion flow tube-chemical ionization mass spectrometry is reported. Formaldehyde in aqueous biological samples is preconcentrated by distillation and directly analyzed using gas-phase thermal energy proton transfer from H30+; this procedure can be performed in 30 min. The method detection limit for formaldehyde based on seven replicate measurements of reference water samples (2.5 mL) is 80 nM at the 99% confidence level. Detection is linear up to 130 microM. This technique allows the first measurement of natural formaldehyde levels in human cancer cells in vitro. Elevated levels of formaldehyde relative to the reference water are observed for doxorubicin-sensitive cells (MCF-7 breast cancer, K562 leukemia, HeLa S3 cervical cancer) with estimated intracellular formaldehyde concentrations ranging from 1.5 to 4.0 microM, whereas formaldehyde in doxorubicin-resistant MCF-7/Adr breast cancer cells is essentially at reference level. This trend is inverted for prostate cancer cells LNCaP (sensitive) and DU-145 (resistant). Correlation of natural formaldehyde level with doxorubicin cytotoxicity is a function of the expression of enzymes that neutralize oxidative stress and the drug efflux pump, P-170 glycoprotein. 相似文献
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97.
Sustainability issues in manufacturing and production are growing exponentially. Initially referring to environmental considerations, sustainability now also encompasses social, ethical and economical responsibilities. This paper focuses on engineering and manufacturing SMEs and outlines a regional study undertaken on a small number of these companies which have succeeded in developing appropriate tools and strategies to satisfy the current ISO 14001 standard. Their experiences, strategies and solutions are used to devise and develop a framework for sustainability management, taking an incremental approach in moving from environmental management, using ISO 14001 as a foundation, to sustainability management which will contribute to an annual sustainability report which is currently only undertaken by large corporations. The framework consists of two levels, with the first focusing on ISO 14001 and the second aimed towards managing all social, environmental and economical aspects within an engineering SME. Key results from the regional study of ISO 14001 certified engineering SMEs highlight the importance of environmental and sustainability awareness programs for top management, eliciting and obtaining their full support and commitment. 相似文献
98.
MICRO-SWEAT is a coupled microwave emission and soilvegetation-atmosphere transfer scheme. It can predict, among other things, the L band (21 cm wavelength) microwave brightness temperature ( T B ) for a smooth bare soil from knowledge of the soil hydraulic properties and local meteorological data. T B is the product of the apparent emissivity ( e app ) and the effective physical temperature of the soil profile ( T eff ). The modelled relationship between e app and average 0-2 cm soil water content was used to develop a simple semi-empirical model, which predicts the near surface water content from knowledge of the particle size distribution and e app . T eff was found to be comparable to the soil temperature at 11 cm depth, and was estimated using a simple sinusoidal function based on thermal diffusivity to extrapolate the temperature at 11 cm depth from knowledge of the diurnal variation in air temperature. The dependence of T B on incidence angle was predicted by MICRO-SWEAT and also incorporated. This simple model was then successfully used to predict the 0-2 cm water content from knowledge of T B, the air temperature regime and the particle size distribution, for data collected at various look angles over three different soils using a truck-based radiometer. 相似文献
99.
This paper addresses the information-modeling issue for SAIL 1, an integrated shopfloor manufacturing system with flexible manufacturing and material-handling capabilities at the City University of Hong Kong. Based on analyses of the system configuration and information flow structure of SAIL 1, this paper presents a data-modeling strategy to model its information system from the system-physical configuration, system-operation control and system-operation monitoring, respectively. By using the IDEF1x methodology to abstract, classify and define the information objects and the interrelationships between them, three semantic data models were constructed in accordance with the system requirements and modeling strategy, from which the internal and external schemata of the SAIL 1 information system can be derived correspondingly. 相似文献
100.