0.8 μW 12-bit SAR ADC sensors interface for RFID applications

The design and first measuring results of an ultra-low power 12 bit successive-approximation ADC for autonomous multi-sensor systems are presented. The comparator and the DAC are optmised for low power consumption. The power consumption is 0.52 μW from a 1.2 V supply with a sample clock of 3.125 kHz and 0.85 μW at 6.25 kHz. This gives 136 pJ per conversion or 66 fJ per conversion step. As per authors’ knowledge, 66 fJ per conversion step is the best reported so far.The ADC was realised in the NXP CMOS 0.14 μm technology; the area was 0.35 mm². Only four metal layers were used in order to allow 3D integration of the sensors.     

Efficient Excitation of Hybrid Modes in a THz Clinotron

Journal of Infrared, Millimeter, and Terahertz Waves - Various regimes of hybrid, bulk-surface, modes being excited in the clinotron oscillator with a sheet electron beam and nonuniform grating...     

Urinary Excretion of Ecdysterone and Its Metabolites Following Spinach Consumption

Scope

The phytosteroid ecdysterone is present in spinach. In this study, the urinary elimination of ecdysterone and its metabolites in humans is investigated following spinach consumption of two different culinary preparations.

Methods and results

Eight participants (four males, four females) ingested 950 (27.1) g sautéed spinach (average [±standard deviation (SD)]) and 912 (70.6) g spinach smoothie as second intervention after washout. Post-administration urines are analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS). After intake of both preparations, ecdysterone and two metabolites, 14-deoxy-ecdysterone, and 14-deoxy-poststerone, are excreted in urine. The maximum concentration of ecdysterone is ranging from 0.09 to 0.41 µg mL⁻¹ after sautéed spinach and 0.08–0.74 µg mL⁻¹ after smoothie ingestion. The total excreted amount (mean% [±SD]) in the urine as a parent drug plus the metabolites is only 1.4 (1.0) for both sautéed spinach and smoothie. The apparent sex related differences in 14-deoxy-poststerone excretion will need further investigations.

Conclusion

Only a small proportion of ecdysterone from spinach is excreted into urine. No significant differences are found in concentration and recovered amount (%) of ecdysterone, 14-deoxy-ecdysterone, and 14-deoxy-poststerone in urine between sautéed spinach and smoothie ingestion. A discrimination between ecdysterone from food or preparations will be challenging based on urinary concentrations only, at least for later post-administration samples.     

On the generation of test patterns for multiple faults

This article presents a new method to generate test patterns for multiple stuck-at faults in combinational circuits. We assume the presence of all multiple faults of all multiplicities and we do not resort to their explicit enumeration: the target fault is a single component of possibly several multiple faults. New line and gate models are introduced to handle multiple fault effect propagation through the circuits. The method tries to generate test conditions that propagate the effect of the target fault to primary outputs. When these conditions are fulfilled, the input vector is a test for the target fault and it is guaranteed that all multiple faults of all multiplicities containing the target fault as component are also detected. The method uses similar techniques to those in FAN and SOCRATES algorithms to guide the search part of the algorithm, and includes several new heuristics to enhance the performance and fault detection capability. Experiments performed on the ISCAS'85 benchmark circuits show that test sets for multiple faults can be generated with high fault coverage and a reasonable increase in cost over test generation for single stuck-at faults.     

Dynamic Regulation of Mitochondrial [Ca2+] in Hippocampal Neurons

While neuronal mitochondria have been studied extensively in their role in health and disease, the rules that govern calcium regulation in mitochondria remain somewhat vague. In the present study using cultured rat hippocampal neurons transfected with the mtRCaMP mitochondrial calcium sensor, we investigated the effects of cytosolic calcium surges on the dynamics of mitochondrial calcium ([Ca²⁺]m). Cytosolic calcium ([Ca²⁺]c) was measured using the high affinity sensor Fluo-2. We recorded two types of calcium events: local and global ones. Local events were limited to a small, 2–5 µm section of the dendrite, presumably caused by local synaptic activity, while global events were associated with network bursts and extended throughout the imaged dendrite. In both cases, cytosolic surges were followed by a delayed rise in [Ca²⁺]m. In global events, the rise lasted longer and was observed in all mitochondrial clusters. At the end of the descending part of the global event, [Ca²⁺]m was still high. Global events were accompanied by short and rather high [Ca²⁺]m surges which we called spikelets, and were present until the complete decay of the cytosolic event. In the case of local events, selective short-term responses were limited to the part of the mitochondrial cluster that was located directly in the center of [Ca²⁺]c activity, and faded quickly, while responses in the neighboring regions were rarely observed. Caffeine (which recruits ryanodine receptors to supply calcium to the mitochondria), and carbonyl cyanide m-chlorophenyl hydrazine (CCCP, a mitochondrial uncoupler) could affect [Ca²⁺]m in both global and local events. We constructed a computational model to simulate the fundamental role of mitochondria in restricting calcium signals within a narrow range under synapses, preventing diffusion into adjacent regions of the dendrite. Our results indicate that local cytoplasmic and mitochondrial calcium concentrations are highly correlated. This reflects a key role of signaling pathways that connect the postsynaptic membrane to local mitochondrial clusters.