Measuring implementation outcome: beyond success and failure

This paper proposes a framework for measuring the impact of a computer-based application in an organization. Recognizing the complexity of the implementation process, the framework is multi-dimensional: it seeks to measure the outcome of an implementation effort on both the people and tasks affected as separate from user's definition of “success”. The framework can be used to support either the quantitative or case study methodologies used in implementation research. Finally, the authors describe a field test of the framework to demonstrate its usefulness in an organizational setting.     

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Due to its essential role in cellular processes, actin is a common target for bacterial toxins. One such toxin, TccC3, is an effector domain of the ABC-toxin produced by entomopathogenic bacteria of Photorhabdus spp. Unlike other actin-targeting toxins, TccC3 uniquely ADP-ribosylates actin at Thr-148, resulting in the formation of actin aggregates and inhibition of phagocytosis. It has been shown that the fully modified F-actin is resistant to depolymerization by cofilin and gelsolin, but their effects on partially modified actin were not explored. We found that only F-actin unprotected by tropomyosin is the physiological TccC3 substrate. Yet, ADP-ribosylated G-actin can be produced upon cofilin-accelerated F-actin depolymerization, which was only mildly inhibited in partially modified actin. The affinity of TccC3-ADP-ribosylated G-actin for profilin and thymosin-β4 was weakened moderately but sufficiently to potentiate spontaneous polymerization in their presence. Interestingly, the Arp2/3-mediated nucleation was also potentiated by T148-ADP-ribosylation. Notably, even partially modified actin showed reduced bundling by plastins and α-actinin. In agreement with the role of these and other tandem calponin-homology domain actin organizers in the assembly of the cortical actin network, TccC3 induced intense membrane blebbing in cultured cells. Overall, our data suggest that TccC3 imposes a complex action on the cytoskeleton by affecting F-actin nucleation, recycling, and interaction with actin-binding proteins involved in the integration of actin filaments with each other and cellular elements.     

Evaluating interfaces with children

Children are very different from adults—they have developing motor skills, limited reach, short attention spans, limited exposure to traditional user interfaces and social protocols. How do we evaluate user interfaces for children? In this paper, we present four evaluative techniques that we have successfully used with children.     

SPECIAL ISSUE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS FOR INDUSTRY - VOLUME I: ADVANCES IN SOFT MODELING TECHNIQUES AND DECISION SUPPORT

ABSTRACT

In this article we propose a methodology for building a lognormal diffusion process with polynomial exogenous factors in order to fit data that present an exponential trend and show deviations with respect to an exponential curve in the observed time interval. We show that such a process approaches a nonhomogeneous lognormal diffusion and proves that it is specially useful in the case when external information (exogenous factors) about the process is not available even though the existence of these influences is clear. An application to the global man-made emissions of methane is provided.     

Optimising the design of a piston-ring pack using DoE methods

This paper shows how design of experiments can be used with a ring-pack simulation program to optimise the design of a piston-ring assembly. Ten factors are varied—six describing the ring profile, three ring tensions, and the lubricant viscosity. Statistical analysis shows that there are some significant interactions between some of the factors—an issue that should be considered when performing test-bed measurements on engines. It is shown that an improved design can be achieved that reduces ring losses by 57% whilst reducing upward oil flow by 39%. This could lead to a 7% improvement in fuel economy provided there are no deleterious effects in other parts of the engine.     

The dimensional nature of same–different discrimination behavior in pigeons.

We studied the dimensional nature of same–different discrimination behavior in pigeons. Birds first learned to discriminate between simultaneously presented displays of 16 identical items (Same arrays) and 16 nonidentical items (Different arrays), conditional on the color of the background. After discrimination mastery, we tested the birds with Mixture arrays comprising both identical and nonidentical items. Accuracy increased and reaction time decreased as the disparity in entropy (a measure of variability) between the arrays increased. As well, within each entropy disparity level, lower entropy values were more discriminable than higher entropy values. These results accord with a logarithmic relation between entropy and discriminative behavior and, thus, with the idea that the discrimination of Same from Different arrays follows Weber's Law. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Recurrence of MDD: A prospective study of personality pathology and cognitive distortions.

Major depressive disorder (MDD) is characterized by a high risk of recurrence, especially among individuals whose initial episode occurs during adolescence. Identifying predictors of recurrence of MDD among young samples is therefore of paramount clinical importance. Survival analytic models were used to evaluate the effects of dysfunctional cognitions and Axis II personality pathology on MDD recurrence in a sample of 130 previously, but not currently, depressed young adults. Participants were initially assessed for depression, dysfunctional attitudes, and personality pathology during their first semester in college and then reevaluated via the Longitudinal Interval Follow-up Evaluation interview every 6 months for 18 months. Baseline level of depressive symptoms significantly (HR-1.07, p = .002) predicted recurrence of MDD. In the survival analyses with baseline level of depression serving as a current mood state covariate, overall personality pathology (HR-1.04, p DSM–IV personality disorder cluster scores uniquely predicted recurrence. We discussed the theoretical, empirical, and clinical implications of these findings, and we noted the limitations of the study. (PsycINFO Database Record (c) 2011 APA, all rights reserved)