Antibacterial,Antibiofilm, and Antiviral Farnesol-Containing Nanoparticles Prevent Staphylococcus aureus from Drug Resistance Development

Multidrug antimicrobial resistance is a constantly growing health care issue associated with increased mortality and morbidity, and huge financial burden. Bacteria frequently form biofilm communities responsible for numerous persistent infections resistant to conventional antibiotics. Herein, novel nanoparticles (NPs) loaded with the natural bactericide farnesol (FSL NPs) are generated using high-intensity ultrasound. The nanoformulation of farnesol improved its antibacterial properties and demonstrated complete eradication of Staphylococcus aureus within less than 3 h, without inducing resistance development, and was able to 100% inhibit the establishment of a drug-resistant S. aureus biofilm. These antibiotic-free nano-antimicrobials also reduced the mature biofilm at a very low concentration of the active agent. In addition to the outstanding antibacterial properties, the engineered nano-entities demonstrated strong antiviral properties and inhibited the spike proteins of SARS-CoV-2 by up to 83%. The novel FSL NPs did not cause skin tissue irritation and did not induce the secretion of anti-inflammatory cytokines in a 3D skin tissue model. These results support the potential of these bio-based nano-actives to replace the existing antibiotics and they may be used for the development of topical pharmaceutic products for controlling microbial skin infections, without inducing resistance development.     

Modeling a grid‐connected concentrator photovoltaic system

A six‐parameter formula is proposed for describing the hourly alternating current performance of a grid‐connected, passively cooled concentrator photovoltaic (CPV) system. These system parameters all have physical meanings, and techniques are described for deriving their numerical values. The predictions of the model are compared with the measured output of a Soitec CPV system at Sede Boqer and found to be accurate to approximately ± 5% at all times of the year. The model should also be valid for systems of similar construction operated in different climates from the system studied here, and also for passively cooled CPV systems of different designs provided that suitable numerical values are determined for their system parameters. Another possible use of the model is as a guide for tailoring CPV cell architecture to the particular spectral conditions of the locations in which they will operate. Attention is drawn to the fact that the numerical values of some of the system parameters are found to depend upon the time binning employed for the data. An explanation is given for this phenomenon, which is also found to occur for non‐concentrating photovoltaic panels. Copyright © 2014 John Wiley & Sons, Ltd.     

Functional Carbon Quantum Dots for Ocular Imaging and Therapeutic Applications

Carbon quantum dots (CDs) are a class of emerging carbonaceous nanomaterials that have received considerable attention due to their excellent fluorescent properties, extremely small size, ability to penetrate cells and tissues, ease of synthesis, surface modification, low cytotoxicity, and superior water dispersion. In light of these properties, CDs are extensively investigated as candidates for bioimaging probes, efficient drug carriers, and disease diagnostics. Functionalized CDs represent a promising therapeutic candidate for ocular diseases. Here, this work reviews the potential use of functionalized CDs in the diagnosis and treatment of eye-related diseases, including the treatment of macular and anterior segment diseases, as well as targeting Aβ amyloids in the retina.