Naila Rabbani  Antonysunil Adaikalakoteswari  James R. Larkin  Sianna Panagiotopoulos  Richard J. MacIsaac  Dennis K. Yue  Gregory R. Fulcher  Matthew A. Roberts  Merlin Thomas  Elif Ekinci  Paul J. Thornalley 《International journal of molecular sciences》2023,24(1)

Accumulation of advanced glycation endproducts (AGEs) is linked to decline in renal function, particularly in patients with diabetes. Major forms of AGEs in serum are protein-bound AGEs and AGE free adducts. In this study, we assessed levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2 to 4 chronic kidney disease (CKD), to identify which AGE has the greatest progressive change with decline in renal function and change in diabetes. We performed a cross-sectional study of patients with stages 2–4 CKD, with and without diabetes, and healthy controls (n = 135). Nine protein-bound and free adduct AGEs were quantified in serum. Most protein-bound AGEs increased moderately through stages 2–4 CKD whereas AGE free adducts increased markedly. Methylglyoxal-derived hydroimidazolone MG-H1 free adduct was the AGE most responsive to CKD status, increasing 8-fold and 30-fold in stage 4 CKD in patients without and with diabetes, respectively. MG-H1 Glomerular filtration flux was increased 5-fold in diabetes, likely reflecting increased methylglyoxal glycation status. We conclude that serum MG-H1 free adduct concentration was strongly related to stage of CKD and increased in diabetes status. Serum MG-H1 free adduct is a candidate AGE risk marker of non-diabetic and diabetic CKD.  相似文献   

    

Tugba Dursun Capar;Elif Meltem Iscimen;David Julian McClements;Hasan Yalcin;Mehmet Hayta; 《Journal of the science of food and agriculture》2024,104(11):6483-6493

Plant proteins are being increasingly utilized as functional ingredients in foods because of their potential health, sustainability, and environmental benefits. However, their functionality is often worse than the synthetic or animal-derived ingredients they are meant to replace. The functional performance of plant proteins can be improved by conjugating them with polyphenols. In this study, the formation and stability of oil-in-water emulsions prepared using faba bean protein–grape leaf polyphenol (FP-GLP) conjugates as emulsifiers. Initially, FP-GLP conjugates were formed using an ultrasound-assisted alkali treatment. Then, corn oil-in-water emulsions were prepared using high-intensity sonication (60% amplitude, 10 min) and the impacts of conjugate concentration, pH, ionic strength, freezing–thawing, and heating on their physicochemical properties and stability were determined.  相似文献   

    

Taishan Zhu  Krishnan Swaminathan‐Gopalan  Kevin J. Cruse  Kelly Stephani  Elif Ertekin 《Advanced functional materials》2018,28(17)

Vibrational energy transport in disordered media is of fundamental importance to several fields spanning from sustainable energy to biomedicine to thermal management. This work investigates hybrid ordered/disordered nanocomposites that consist of crystalline membranes decorated by regularly patterned disordered regions formed by ion beam irradiation. The presence of the disordered regions results in reduced thermal conductivity, rendering these systems of interest for use as nanostructured thermoelectrics and thermal device components, yet their vibrational properties are not well understood. Here, the mechanism of vibrational transport and the reason underlying the observed reduction is established in detail. The hybrid systems are found to exhibit glass‐crystal duality in vibrational transport. Lattice dynamics reveals substantial hybridization between the localized and delocalized modes, which induces avoided crossings and harmonic broadening in the dispersion. Allen/Feldman theory shows that the hybridization and avoided crossings are the dominant drivers of the reduction. Anharmonic scattering is also enhanced in the patterned nanocomposites, further contributing to the reduction. The systems exhibit features reminiscent of both nanophononic materials and locally resonant nanophononic metamaterials, but operate in a manner distinct to both. These findings indicate that such “patterned disorder” can be a promising strategy to tailor vibrational transport through hybrid nanostructures.  相似文献   

    

Derya Haroglu  Nancy Powell  Abdel-Fattah M. Seyam 《纺织学会志》2017,108(1):49-57

In our previous publications, the response of perfluorinated (PF) graded index (GI) POFs (62.5/750, 62.5/490 μm) to bending, tensile loading, and cyclic loading was investigated. The results showed that Cytop-1 (62.5/750 μm) was more appropriate to be used as an optical fiber sensor for automotive seat occupancy sensing relative to Cytop-2 (62.5/490 μm). In this study, a textile-based optical fiber sensor was designed and the effect of automotive seat covering including face material and foam backing on a sensor’s performance was analyzed. The pressure interval under which the proposed POF sensor design could perform well was found to be between 0.18 and 0.21 N/cm², where PF GI POF (62.5/750 μm) was used as the POF material. The responses of the sensor in this interval were observed to be accurate and reproducible. The face fabric structure and the thickness of foam backing were not found to be significant factors to change the sensor response. Artificial neural network (ANN) was used for data analysis, and Qwiknet (version 2.23) software was used to develop ANNs. According to the results of Qwiknet, the prediction performances for training and testing data-sets were 75 and 83.33%, respectively.  相似文献   

    

Derya Haroglu  Nancy Powell  Abdel-Fattah M. Seyam 《纺织学会志》2017,108(1):132-139

The automotive industry is a promising area for innovations in the field of polymer optical fiber (POF) sensors as the industry currently uses the POF mostly for data transmissions. Since an optical fiber sensor has a high bandwidth, is small in size, is lightweight, and is immune to electromagnetic interference, it offers higher performance than that of its electrical-based counterparts such as the strain gage, elastomeric bladder, and resistive sensor systems. This enhanced performance makes an optical fiber sensor a suitable material for sensing seat occupancy for improved safety features in automobiles. The overall goal of this research is to develop a textile-based optical fiber sensor for automotive seat occupancy with high accuracy and reproducibility. In this study, the bending and tensile loading responses of POF were investigated, where two perfluorinated (PF) graded index (GI) POFs with two different core/cladding diameters, 62.5/750 and 62.5/490 μm, were used. The bending loss and the light attenuation against the applied axial stress were measured by a photon counting optical time-domain reflectometer. The critical bending diameters were analyzed: Cytop-1 (62.5/750 μm)?≥?38.10 mm, Cytop-2 (62.5/490 μm)?≥?44.45 mm. Furthermore, the elastic sensitive strain regions (x), where the stress-induced loss was recoverable, of the POFs at a 76.2 mm gage length at a strain rate of 4 mm/min were determined: Cytop-1: 3% ≤ x ≤ 3.5%, Cytop-2: 3.1% ≤ x ≤ 3.3%. The Cytop-1 was found to be less sensitive to bending and to have greater elastic sensitive strain range relative to the Cytop-2. In this study, a theoretical approach of the PF GI POF behavior to bending and axial tension was provided. The results demonstrated the feasibility of POFs as optical fiber sensors for automotive seat occupancy sensing.  相似文献   

    

Derya Deliktas  Ozden Ustun 《International Transactions in Operational Research》2017,24(5):1173-1195

Student selection is a multicriteria decision‐making problem that includes both tangible and intangible factors. In these problems if educational institutions have budget or other different constraints, two problems will exist: which students are the best and how students are assigned to the predefined programs? In this study, an integrated approach of fuzzy MULTIMOORA and multichoice conic goal programming is proposed to consider criteria in choosing the best students and define the optimum assignments among the predefined programs to maximize both the total preference value and total ranking value. The rankings of the students are determined by using fuzzy MULTIMOORA. The rankings of candidates are set as the parameters of the first objective function. The placement preferences of the students according to the predefined programs are considered in the second objective function. The candidates are assigned to their placement preferences both by using multichoice conic goal programming among partner universities according to the objectives and by considering the budget and quota.  相似文献   

    

Elif Kabakci  Göksin Sayer  Ender Suvaci  Oktay Uysal  İhsan Güler  Metin Kaya 《应用聚合物科学杂志》2017,134(21)

Rigid polyurethane (PU) foam is used as a thermal insulating and supporting material in domestic refrigerator/freezers and it is produced by reaction injection molding (RIM) process. There is a need to improve the thermal property of rigid PU foam but this is still a challenging problem. Accordingly, this work investigates the RIM process parameters to evaluate their effects on rigid PU foam's structure and hence property. It has been found that mold temperature is a key parameter whereas curing time has negligible effect on structure of PU foam. Cell size, strut thickness, and foam density have been found very critical in controlling the thermal and mechanical properties. Upper and lower values of 30 to 32 kg/m³ density are critical to observe contribution of radiation and solid conductivity separately. Finally, PU foam with 160 µm average cell size, 16 µm strut thickness, below 10% open cell content, and 30 to 32 kg/m³ density allow obtaining better thermal insulation without significant reducing in the compressive strength. The presented work provides a better understanding of processing‐structure‐property relationship to gain knowledge on producing high‐quality rigid PU foams with improved properties. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 44870.  相似文献   

    

Yasuhiro Fukuda  Derya Aytemiz  Akira Higuchi  Yuya Ichida  Tetsuo Asakura  Tsunenori Kameda  Yasumoto Nakazawa 《应用聚合物科学杂志》2017,134(48)

Materials such as expanded polytetrafluoroethylene and glutaraldehyde‐fixed bovine pericardium are currently used for cardiac tissue regeneration. However, patches made from these materials remain permanently without being absorbed by the body and must be replaced overtime because of degeneration or lack of growth. To improve the long‐term outcomes for cardiac tissue regeneration, biocompatible and biodegradable materials must be used. In this study, we used two biocompatible polymers, silk fibroin (SF), which is biodegradable and segmented polyurethane, to prepare nonwoven sheets that were then insolubilized by water vapor or methanol treatment. The tensile stress increased significantly on adding segmented polyurethane to pure SF and the water vapor processed sheets showed higher extension on strain than the methanol‐processed sheets. The different insolubilization treatments also resulted in different SF structures. Our results show that it is possible to obtain the physical properties required for cardiac tissue repair patch by varying the insolubilization treatment. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45560.  相似文献   

    

Pedro Gomes  Derya Tama  Hlder Carvalho  Antnio Pedro Souto 《Coloration Technology》2020,136(2):130-136

This research study focuses on the application of conductive ink by the screen printing technique to evaluate the potential of creating printed electrodes and to investigate the effect of washing upon electrical resistance and flexibility. Two conductive inks were applied by a conventional screen printing method on four different textile substrates, 100% cotton, 50%/50% cotton/polyester, 100% polyester and 100% polyamide. The inks were also applied on a multifibre fabric. Atmospheric plasma treatment was applied to improve the adhesion to the samples, and the resistance values were compared with those of non‐treated samples. The values were measured before and after cleaning and washing tests, which were performed to simulate domestic treatment for garments to predict the behaviour of the inks after normal usage of the fabrics. Comfort properties like stiffness of the fabrics were also evaluated after five and 10 washing cycles. It was observed that PE 825 ink forms a thicker film on the fabric surface, contributing to the loss of flexibility of the textile. However, PE 825 ink also produced the best results in terms of durability and lower values of resistance. Polyamide fabrics lost their conductive property after five washing cycles due to weak bonding between the ink and the fibres, whereas cotton fibres provided the best results.  相似文献   

    

Elif Ozyilmaz  Serkan Sayin 《Polycyclic Aromatic Compounds》2018,38(3):272-281

The dihydrazide calix[4]arene was immobilized onto sporopollenin in order to encapsulate Candida rugosa lipase (CRL) via sol-gel entrapment. The kinetic resolution of the new encapsulated lipase was investigated for enantioselective hydrolysis of racemic naproxen methyl ester and 2-phenoxypropionic acid methyl ester. The results demonstrated that the activity and enantioselectivity of the lipase were improved when the lipase was encapsulated in the presence of calix[4]arene-immobilized sporopollenin. The encapsulated lipase showed an excellent rate of enantioselectivity against the (R/S)-naproxen methyl and (R/S)-2-phenoxypropionic acid methyl esters, with E = 350 and 295, respectively, compared to the free enzyme.  相似文献