全文获取类型
收费全文 | 679篇 |
免费 | 23篇 |
专业分类
电工技术 | 5篇 |
化学工业 | 278篇 |
金属工艺 | 9篇 |
机械仪表 | 19篇 |
建筑科学 | 13篇 |
矿业工程 | 1篇 |
能源动力 | 19篇 |
轻工业 | 110篇 |
水利工程 | 1篇 |
石油天然气 | 1篇 |
无线电 | 33篇 |
一般工业技术 | 88篇 |
冶金工业 | 35篇 |
原子能技术 | 10篇 |
自动化技术 | 80篇 |
出版年
2023年 | 10篇 |
2022年 | 58篇 |
2021年 | 59篇 |
2020年 | 18篇 |
2019年 | 19篇 |
2018年 | 17篇 |
2017年 | 17篇 |
2016年 | 21篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 54篇 |
2012年 | 36篇 |
2011年 | 41篇 |
2010年 | 39篇 |
2009年 | 38篇 |
2008年 | 49篇 |
2007年 | 28篇 |
2006年 | 20篇 |
2005年 | 23篇 |
2004年 | 15篇 |
2003年 | 4篇 |
2002年 | 8篇 |
2001年 | 9篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 9篇 |
1997年 | 8篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1990年 | 5篇 |
1989年 | 1篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有702条查询结果,搜索用时 15 毫秒
611.
Claudia Sanna Chiara Rosso Milena Marietti Elisabetta Bugianesi 《International journal of molecular sciences》2016,17(5)
Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease but the second cause of death among NAFLD patients are attributed to malignancies at both gastrointestinal (liver, colon, esophagus, stomach, and pancreas) and extra-intestinal sites (kidney in men, and breast in women). Obesity and related metabolic abnormalities are associated with increased incidence or mortality for a number of cancers. NAFLD has an intertwined relationship with metabolic syndrome and significantly contributes to the risk of hepatocellular carcinoma (HCC), but recent evidence have fuelled concerns that NAFLD may be a new, and added, risk factor for extra-hepatic cancers, particularly in the gastrointestinal tract. In this review we critically appraise key studies on NAFLD-associated extra-hepatic cancers and speculate on how NAFLD may influence carcinogenesis at these sites. 相似文献
612.
Claudia Crocini Raffaele Coppini Cecilia Ferrantini Ping Yan Leslie M. Loew Corrado Poggesi Elisabetta Cerbai Francesco S. Pavone Leonardo Sacconi 《International journal of molecular sciences》2016,17(9)
Alterations of the β-adrenergic signalling, structural remodelling, and electrical failure of T-tubules are hallmarks of heart failure (HF). Here, we assess the effect of β-adrenoceptor activation on local Ca2+ release in electrically coupled and uncoupled T-tubules in ventricular myocytes from HF rats. We employ an ultrafast random access multi-photon (RAMP) microscope to simultaneously record action potentials and Ca2+ transients from multiple T-tubules in ventricular cardiomyocytes from a HF rat model of coronary ligation compared to sham-operated rats as a control. We confirmed that β-adrenergic stimulation increases the frequency of Ca2+ sparks, reduces Ca2+ transient variability, and hastens the decay of Ca2+ transients: all these effects are similarly exerted by β-adrenergic stimulation in control and HF cardiomyocytes. Conversely, β-adrenergic stimulation in HF cells accelerates a Ca2+ rise exclusively in the proximity of T-tubules that regularly conduct the action potential. The delayed Ca2+ rise found at T-tubules that fail to conduct the action potential is instead not affected by β-adrenergic signalling. Taken together, these findings indicate that HF cells globally respond to β-adrenergic stimulation, except at T-tubules that fail to conduct action potentials, where the blunted effect of the β-adrenergic signalling may be directly caused by the lack of electrical activity. 相似文献
613.
Elisabetta Berti Franco Cecconi Carlo A. Ghilardi Stefano Midollini Annabella Orlandini Emanuela Pitzalis 《Inorganic chemistry communications》2002,5(12):3179
New organic–inorganic hybrid materials have been synthesized by reaction in water solution of manganese, cobalt or nickel acetates with P,P′-diphenylmethylenediphosphinic acid and all the two-dimensional structure coordination polymers obtained have been found to be isomorphous. 相似文献
614.
Federica Chiellini Federica Petrucci Elisabetta Ranucci Roberto Solaro 《应用聚合物科学杂志》2002,85(13):2729-2741
Biocompatible polymers with specific shape and tailored hydrogel properties were obtained by polymerization of mixtures of 2‐hydroxyethyl methacrylate (HEMA) with 1–8 wt % ethylene glycol dimethacrylate (EGDMA) or tetra(ethylene glycol) diacrylate (TEGDA) as crosslinking agents, by using a redox initiator. Introduction of charged positive and negative groups was easily achieved by direct polymerization of appropriate monomer mixtures and by chemical transformation of preformed hydrogels. Investigation of the swelling behavior of the prepared hydrogels evidenced an appreciable dependence on both solvent type and polymer chemical structure. Additionally, the solvation process resulted in being controlled by solvent diffusion, according to a Fickian II mechanism. The presence of several types of water with different melting behavior was observed in fully swollen hydrogels. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 2729–2741, 2002 相似文献
615.
The combined effect of a channel-based approach for dry pressure drop and the Buchanan equation for wet pressure drop in packed beds has been numerically evaluated within the flooding region. The flooding point is an important design parameter since it establishes the maximum hydrodynamic capacity at which a packed column can operate. Upon analyzing the aforementioned approach, it was found that the usual practice of fixing a “reasonable” wet pressure drop at the flooding point (e.g., 1025 Pa/m) may not yield the correct flooding velocity of the gas, particularly at higher liquid loads. In fact, numerical evaluations of the aforementioned model showed a rather “retrograde” non-monotonic behavior of pressure drop with respect to the f factor of the gas near flooding at different liquid loads. A calculation procedure was therefore devised in this work to correctly compute the flooding point for a given liquid load when using the aforementioned modeling approach. Interestingly, it was found that the correct flooding velocity can be directly computed from liquid holdup below the gas loading point. To illustrate the use of the procedure, maximum capacity calculations were performed for a well-known random packing, a conventional structured packing, and a novel catalytic structured packing. 相似文献
616.
Antonio Gnoni Antonella Licchetta Aldo Scarpa Amalia Azzariti Anna Elisabetta Brunetti Gianni Simone Patrizia Nardulli Daniele Santini Michele Aieta Sabina Delcuratolo Nicola Silvestris 《International journal of molecular sciences》2013,14(10):19731-19762
Pancreatic adenocarcinoma displays a variety of molecular changes that evolve exponentially with time and lead cancer cells not only to survive, but also to invade the surrounding tissues and metastasise to distant sites. These changes include: genetic alterations in oncogenes and cancer suppressor genes; changes in the cell cycle and pathways leading to apoptosis; and also changes in epithelial to mesenchymal transition. The most common alterations involve the epidermal growth factor receptor (EGFR) gene, the HER2 gene, and the K-ras gene. In particular, the loss of function of tumor-suppressor genes has been documented in this tumor, especially in CDKN2a, p53, DPC4 and BRCA2 genes. However, other molecular events involved in pancreatic adenocarcinoma pathogenesis contribute to its development and maintenance, specifically epigenetic events. In fact, key tumor suppressors that are well established to play a role in pancreatic adenocarcinoma may be altered through hypermethylation, and oncogenes can be upregulated secondary to permissive histone modifications. Indeed, factors involved in tumor invasiveness can be aberrantly expressed through dysregulated microRNAs. This review summarizes current knowledge of pancreatic carcinogenesis from its initiation within a normal cell until the time that it has disseminated to distant organs. In this scenario, highlighting these molecular alterations could provide new clinical tools for early diagnosis and new effective therapies for this malignancy. 相似文献
617.
618.
Stefania Mitola Cosetta Ravelli Michela Corsini Alessandra Gianoncelli Federico Galvagni Kurt Ballmer-Hofer Marco Presta Elisabetta Grillo 《International journal of molecular sciences》2022,23(3)
Gremlin-1 is a secreted cystine-knot protein that acts as an antagonist of bone morphogenetic proteins (BMPs), and as a ligand of heparin and the vascular endothelial growth factor receptor 2 (VEGFR2), thus regulating several physiological and pathological processes, including embryonic development, tissue fibrosis and cancer. Gremlin-1 exerts all these biological activities only in its homodimeric form. Here, we propose a multi-step approach for the expression and purification of homodimeric, fully active, histidine-tagged recombinant gremlin-1, using mammalian HEK293T cells. Ion metal affinity chromatography (IMAC) of crude supernatant followed by heparin-affinity chromatography enables obtaining a highly pure recombinant dimeric gremlin-1 protein, exhibiting both BMP antagonist and potent VEGFR2 agonist activities. 相似文献
619.
620.
Roberta Belli Elisabetta Ferraro Alessio Molfino Raffaella Carletti Federica Tambaro Paola Costelli Maurizio Muscaritoli 《International journal of molecular sciences》2021,22(16)
Cancer cachexia displays a complex nature in which systemic inflammation, impaired energy metabolism, loss of muscle and adipose tissues result in unintentional body weight loss. Cachectic patients have a poor prognosis and the presence of cachexia reduces the tolerability of chemo/radio-therapy treatments and it is frequently the primary cause of death in advanced cancer patients. Early detection of this condition could make treatments more effective. However, early diagnostic biomarkers of cachexia are currently lacking. In recent years, although solid biopsy still remains the “gold standard” for diagnosis of cancer, liquid biopsy is gaining increasing interest as a source of easily accessible potential biomarkers. Moreover, the growing interest in circulating microRNAs (miRNAs), has made these molecules attractive for the diagnosis of several diseases, including cancer. Some muscle-derived circulating miRNA might play a pivotal role in the onset/progression of cancer cachexia. This topic is of great interest since circulating miRNAs might be easily detectable by means of liquid biopsies and might allow an early diagnosis of this syndrome. We here summarize the current knowledge on circulating muscular miRNAs involved in muscle atrophy, since they might represent easily accessible and promising biomarkers of cachexia. 相似文献