Symbolic time-series analysis for anomaly detection in mechanical systems

This paper examines the efficacy of a novel method for anomaly detection in mechanical systems, which makes use of a hidden Markov model, derived from the time-series data of pertinent measurement(s). The core concept of the anomaly detection method is symbolic time-series analysis that is built upon the principles of Automata Theory, Information Theory, and Pattern Recognition. The performance of this method is compared with that of other existing pattern-recognition techniques from the perspective of early detection of small fatigue cracks in ductile alloy structures. The experimental apparatus, on which the anomaly detection method is tested, is a multi-degree-of-freedom mass-beam structure excited by oscillatory motion of two electromagnetic shakers. The evolution of fatigue crack damage at one or more failure sites are detected from symbolic time-series analysis of displacement sensor signals.     

Behavioral observation scales for measuring children's distress: The effects of increased methodological rigor.

In Exp I, the Observation Scale of Behavioral Distress (OSBD), a revision of the Procedure Behavioral Rating Scale, was used to evaluate 42 pediatric cancer patients undergoing bone marrow aspiration procedures. In Exp II, 31 pediatric cancer patients were evaluated using the same procedures as in Exp I. In both experiments, parents rated their child's anxiety. Results show that Ss habituated but that the OSBD had little effect on validity or habituation data. The failure to find significant differences in validity measures with an increase in sophistication of the measurement techniques may be related to the nature of the situation and to types of behaviors recorded. In acute and intense situations, gross behavioral recordings of the presence or absence of behaviors may be sufficient. (3 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Screw-theoretic analysis framework for cooperative payload transport by mobile manipulator collectives

In recent times, there has been considerable interest in creating and deploying modular cooperating collectives of robots. Interest in such cooperative systems typically arises when certain tasks are either too complex to be performed by a single agent or when there are distinct benefits that accrue by cooperation of many simple robotic modules. However, the nature of both the individual modules as well as their interactions can affect the overall system performance. In this paper, we examine this aspect in the context of cooperative payload transport by robot collectives wherein the physical nature of the interactions between the various modules creates a tight coupling within the system. We leverage the rich theoretical background of analysis of constrained mechanical systems to provide a systematic framework for formulation and evaluation of system-level performance on the basis of the individual-module characteristics. The composite multi-degree-of-freedom (DOF) wheeled vehicle, formed by supporting a common payload on the end-effectors of multiple individual mobile manipulator modules, is treated as an in-parallel system with articulated serial-chain arms. The system-level model, constructed from the twist- and wrench-based models of the attached serial chains, can then be systematically analyzed for performance (in terms of mobility and disturbance rejection). A two-module composite system example is used throughout the paper to highlight various aspects of methodical system model formulation, effects of selection of active, passive or locked articulations on system performance, and experimental validation on a hardware prototype test bed.     

The Sexual Health Help Centre: a service for young people

BACKGROUND: The Sexual Health Help Centre (SHHC) was opened in 1995 to provide treatment, advice and information on family planning and sexual health issues for young people under the age of 20 years, in a way which is open and non-threatening. This paper describes an evaluation conducted during the first 9 months of service operation. METHODS: Young people's experience of the SHHC were elicited, and compared with their experiences of conventional family planning services in Glasgow. RESULTS: The SHHC has been successful in attracting young people for help with family planning problems and provides a more acceptable environment than conventional family planning services. However, a greater number of young men and young people under the age of 16 should be encouraged to attend the service. CONCLUSION: Young people are more likely to visit family planning services if they are offered a wide range of family planning and sexual health services in a non-judgmental, non-threatening environment.     

Growth and morphological transformations of Helicobacter pylori in broth media

Helicobacter pylori, a cause of peptic ulcer disease and certain types of gastric cancers, has usually been cultured on diverse agar-based media, resulting in a requirement for 2 to 4 days of growth at 37 degrees C. We have developed a novel broth medium consisting of a base medium supplemented with 2% newborn calf serum, Mg2+, Cu2+, Fe2+, Zn2+, Mn2+, and 1 mg of lysed human erythrocytes per ml. This medium supports rapid growth of H. pylori, with a doubling time of about 50 min. Optimal growth was obtained in a pH range higher than that supporting most other gram-negative bacteria (at pH 8.5). H. pylori cultured in this supplemented broth retains the spiral morphology seen in both histological sections and cultures from agar-based media and also retains a high urease activity. After 18 h in this broth, H. pylori transforms to a coccal form with a complete loss of urease activity. Previously these cocci have been reported to be senescent, since they could not be subcultured on agar medium. Our experiments suggest that some of the cocci can revert back to the spiral morphology with full recovery of urease activity when subcultured in fresh microaerobic broth medium.     

The methodology of cost-effectiveness analysis: avoiding common pitfalls

Clinicians need to be familiar with the core methodology of cost-effectiveness economic analysis, as this information will increasingly be used in clinical decision-making. Just as in clinical trials, there are rules to be followed, and many pitfalls for the novice.     

Syncope and ventricular arrhythmias in hypertrophic cardiomyopathy are not related to the derangement of coronary microvascular function

Non-sustained ventricular tachycardia on Holter and syncope have been considered risk factors for sudden death in hypertrophic cardiomyopathy. AIMS: In these patients the coronary vasodilator reserve is impaired despite normal coronaries, so we evaluated the correlation between the severity of coronary vasodilator reserve impairment and the occurrence of syncope and non-sustained ventricular tachycardia. METHODS AND RESULTS: Eighty-four patients with hypertrophic cardiomyopathy (62 males, age 43 +/- 12 years) had a two-dimensional echocardiographic study and a 48-h Holter. Myocardial blood flow was measured by positron emission tomography, at baseline and after dipyridamole, and the coronary vasodilator reserve was computed as dipyridamole myocardial blood flow/baseline myocardial blood flow. In 27 patients, subendocardial and subepicardial myocardial blood flow was measured in the septum and the subendocardial/subepicardial ratio was computed. Twenty of 84 patients had at least one syncopal episode, and 26 had at least one run of non-sustained ventricular tachycardia on Holter. Baseline and dipyridamole myocardial blood flow, coronary vasodilator reserve, and baseline and dipyridamole subendocardial/subepicardial myocardial blood flow ratio were similar in patients with and without syncope and with and without non-sustained ventricular tachycardia on Holter. However, patients with non-sustained ventricular tachycardia had larger left ventricular end-diastolic (47 +/- 6 vs 44 +/- 5 mm, P < 0.05) and end-systolic diameters (30 +/- 6 vs 27 +/- 4 mm, P < 0.05). CONCLUSIONS: (1) Coronary vasodilation is not more severely impaired in patients with hypertrophic cardiomyopathy and syncope or non-sustained ventricular tachycardia. (2) The left ventricle is more dilated in hypertrophic cardiomyopathy with non-sustained ventricular tachycardia.     

Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995

The aim of this research, which remains in progress, has been the examination of long-term psychological consequences for survivors of intensive care. Seventy-two patients were followed up for 1 year, after discharge from the Intensive Care Unit (ICU) at St James's University Hospital in Leeds. Major objectives of the study included assessment of patients' sense of well-being at specified intervals post-discharge, and identification of ICU-related variables which might influence psychological recovery. Psychometric assessments used were the General Health Questionnaire 28-item version, the Rosenberg Self-esteem Scale, and the Impact of Event scale. This paper describes findings from the research so far. An exploratory analysis of the data suggests that distinctions can be drawn among surviving patients with regard to psychological recovery, by way of variables such as type of illness, mode of admission and amount of recall. The work expands previous research into post-ICU psychology and quality of life, and should allow increased understanding of this patient group.