Female Wistar-Kyoto and SHR/y rats have the same genotype but different patterns of expression of renin and angiotensinogen genes

BACKGROUND: Prevalence estimates vary 2750-fold among the 20 studies of essential tremor (ET). It is not clear how the choice of diagnostic criteria affects research results. OBJECTIVE: To determine the impact of alternative sets of diagnostic criteria on the diagnosis of ET. METHODS: As part of the Washington Heights-Inwood Genetic Study of ET (WHIGET), a population-based study of ET, 285 subjects who include 36 case subjects with probable or definite ET, 34 case subjects with possible ET, and 215 normal subjects were interviewed and examined. All diagnoses in WHIGET were assigned by 2 neurologists. Ten of the 20 published prevalence studies of ET provided diagnostic criteria for ET. Criteria differed in terms of requirements for the distribution, duration, and severity of tremor. These 10 sets of criteria were then each separately applied to the subjects in the WHIGET cohort to determine their impact on the diagnosis of ET. RESULTS: Depending on which diagnostic criteria were applied to the WHIGET cohort, the proportion of WHIGET case subjects with definite or probable ET who would have been diagnosed as having ET was as low as 14% and the proportion of WHIGET normal subjects who would have been diagnosed as having ET was as high as 51%. Diagnostic criteria that included a positive family history of ET or a lengthy duration of tremor would have classified many WHIGET case subjects with ET as normal, whereas criteria that did not specify a minimal tremor severity would have classified many WHIGET normal subjects as having ET. CONCLUSIONS: Alternative sets of diagnostic criteria for ET greatly impact on the diagnosis of ET. For population-based studies, information on tremor type and severity rather than family history should be included in diagnostic criteria.     

Orthogonal decompositions of 2-D nonhomogeneous discrete random fields

Imposing atotal-order on a two-dimensional (2-D) discrete random field induces an orthogonal decomposition of the random field into two components: Apurely-indeterministic field and adeterministic one. The purely-indeterministic component is shown to have a 2-D white-innovations driven moving-average representation. The 2-D deterministic random field can be perfectly predicted from the field's past with respect to the imposed total-order definition. The deterministic field is further orthogonally decomposed into anevanescent field, and aremote past field. The evanescent field is generated by the columnto-column innovations of the deterministic field with respect to the imposed nonsymmetrical-half-plane total-ordering definition. The presented decomposition can be obtained with respect to any nonsymmetrical-half-plane total-ordering definition, for which the nonsymmetrical-half-plane boundary line has rational slope.     

A frequency domain algorithm for multiframe detection andestimation of dim targets

An algorithm for detecting moving targets by imaging sensors and estimating their trajectories is proposed. The algorithm is based on directional filtering in the frequency domain, using a bank of filters for all possible target directions. The directional filtering effectively integrates the target signal, resulting in an improved signal-to-noise ratio. Working in the frequency domain facilitates a considerable reduction in computational requirements compared to time-domain algorithms. The algorithm is described in detail, and its false alarm and detection probabilities are analyzed     

Crosswind sensing from optical-turbulence-induced fluctuations measured by a video camera

We present a novel method for remote sensing of crosswind using a passive imaging device, such as a video recorder. The method is based on spatial and temporal correlations of the intensity fluctuations of a naturally illuminated scene induced by atmospheric turbulence. Adaptable spatial filtering, taking into account variations of the dominant spatial scales of the turbulence (due to changes in meteorological conditions, such as turbulence strength, or imaging device performance, such as frame rate or spatial resolution), is incorporated into this method. Experimental comparison with independent wind measurement using anemometers shows good agreement.     

Antibiotic resistance pattern of enterotoxigenic Escherichia coli isolated from infants and young adults in Israel

BACKGROUND: The usual methods of closure of major chest and abdominal wall defects have significant disadvantages. Skin grafts provide no structural support and result in incisional hernias. Synthetic mesh requires skin cover and is prone to infection and wound breakdown. The tensor fasciae latae (TFL) myocutaneous flap offers skin cover and a semi-rigid fascial layer. We document our unit's experience in pedicled and free TFL flaps. METHODS: The TFL flap closure of trunk defects was undertaken in 10 patients between August 1989 and April 1997. All cases were not amenable to primary closure and repair with synthetic mesh or skin grafts. RESULTS: The defect was satisfactorily repaired in all cases without subsequent herniation. The closure techniques using a pedicled TFL flap and a TFL flap for a free-tissue transfer are described. CONCLUSIONS: We conclude that the TFL flap is the method of choice for repairs of major truncal defects.     

Twenty-four-hour heart preservation using continuous cold perfusion and copper (II) complexes

Spinocerebellar ataxia 7 (SCA7) is a neurodegenerative disorder characterized by degeneration of the cerebellum, brainstem and retina. The gene responsible for SCA7, located on chromosome 3p, recently was cloned and shown to contain a CAG repeat in the coding region of the gene, that is expanded in SCA7 patients of French origin. We examined the SCA7 repeat region in four Swedish SCA7 families as well as in 57 healthy controls. All Swedish SCA7 patients exhibited expanded CAG repeats with a strong negative correlation between repeat size and age of onset. The repeat length in SCA7 patients ranged from 40 to >200 repeats. The largest expansion was observed in a juvenile case with an age of onset of 3 months, and represents the longest polyglutamine stretch ever reported. In patients with 59 repeats or more, visual impairment was the most common initial symptom observed, while ataxia predominates in patients with <59 repeats. Two of the Swedish SCA7 families analysed in this study were shown to be related genealogically. The other two SCA7 families could not be traced back to a common ancestor. All four families shared the same allele on the disease chromosome at a locus closely linked to SCA7, suggesting the possibility of a founder effect in the Swedish population.