Author Keywords: City; History; Virtual; Urban; Town planning 相似文献
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61.
Sabrina Vantadori Andrea Carpinteri Karolina Gowacka Fabrizio Greco Tomasz Osiecki Camilla Ronchei Andrea Zanichelli 《Fatigue & Fracture of Engineering Materials & Structures》2021,44(1):3-13
By examining the state of the art, it can be realised that few research works have been done on the fracture behaviour of plastic composites reinforced with continuous glass fibres. Therefore, the present paper deals with the fracture toughness of a unidirectional glass fibre‐reinforced plastic (GFRP), such a parameter being analytically determined by means of the modified two‐parameter model (MTPM). The input data of the MTPM are obtained from an experimental campaign related to three‐point bending tests on single edge‐notched specimens characterised by different sizes. The novelty of this research work is that the MTPM, originally proposed for isotropic materials, is here employed to estimate the fracture toughness of GFRPs characterised by orthotropic mechanical properties. 相似文献
62.
Mariusz Mital Kosma Szutkowski Karolina Bossak-Ahmad Piotr Skrobecki Simon C. Drew Jarosaw Poznaski Igor Zhukov Tomasz Frczyk Wojciech Bal 《International journal of molecular sciences》2020,21(23)
The A peptide is a major beta-amyloid species in the human brain, forming toxic aggregates related to Alzheimer’s Disease. It also strongly chelates Cu(II) at the N-terminal Phe-Arg-His ATCUN motif, as demonstrated in A and A model peptides. The resulting complex resists ROS generation and exchange processes and may help protect synapses from copper-related oxidative damage. Structural characterization of Cu(II)A complexes by NMR would help elucidate their biological function, but is precluded by Cu(II) paramagneticism. Instead we used an isostructural diamagnetic Pd(II)-A complex as a model. To avoid a kinetic trapping of Pd(II) in an inappropriate transient structure, we designed an appropriate pH-dependent synthetic procedure for ATCUN Pd(II)A, controlled by CD, fluorescence and ESI-MS. Its assignments and structure at pH 6.5 were obtained by TOCSY, NOESY, ROESY, H-C HSQC and H-N HSQC NMR experiments, for natural abundance C and N isotopes, aided by corresponding experiments for Pd(II)-Phe-Arg-His. The square-planar Pd(II)-ATCUN coordination was confirmed, with the rest of the peptide mostly unstructured. The diffusion rates of A, Pd(II)-A and their mixture determined using PGSE-NMR experiment suggested that the Pd(II) complex forms a supramolecular assembly with the apopeptide. These results confirm that Pd(II) substitution enables NMR studies of structural aspects of Cu(II)-A complexes. 相似文献
63.
This Paper discusses the use of modern techniques to gather, convert and present the historic facts concerning the shape of the city—for an example of Warsaw. The aim of the project is to analyse chances of cooperative use of historic data base and contemporary software in intention to create virtual model of the old urban structure.
The deepest source of understanding the contemporary nature of the city is genuine consciousness of its history.
64.
Zaleszczyk W Janik E Presz A Dłuzewski P Kret S Szuszkiewicz W Morhange JF Dynowska E Kirmse H Neumann W Petroutchik A Baczewski LT Karczewski G Wojtowicz T 《Nano letters》2008,8(11):4061-4065
It is shown that the growth of II-VI diluted magnetic semiconductor nanowires is possible by the catalytically enhanced molecular beam epitaxy (MBE). Zn(1-x)MnxTe NWs with manganese content up to x=0.60 were produced by this method. X-ray diffraction, Raman spectroscopy, and temperature dependent photoluminescence measurements confirm the incorporation of Mn(2+) ions in the cation substitutional sites of the ZnTe matrix of the NWs. 相似文献
65.
Barnes CA Elsaesser A Arkusz J Smok A Palus J Leśniak A Salvati A Hanrahan JP Jong WH Dziubałtowska E Stepnik M Rydzyński K McKerr G Lynch I Dawson KA Howard CV 《Nano letters》2008,8(9):3069-3074
Genotoxicity of commercial colloidal and laboratory-synthesized silica nanoparticles was tested using the single cell gel electrophoresis or Comet assay. By using a carefully developed protocol and careful characterization of the nanoparticle dispersions, Comet assays were performed on 3T3-L1 fibroblasts with 3, 6, and 24 h incubations and 4 or 40 microg/ml of silica nanoparticles. No significant genotoxicity was observed for the nanoparticles tested under the conditions described, and results were independently validated in two separate laboratories, showing that in vitro toxicity testing can be quantitatively reproducible. 相似文献
66.
Aleksandra Korbut Marcin Wodarczyk Karolina Rudnicka Aleksandra Szwed Przemysaw Pociski Monika Biernat Paulina Tymowicz-Grzyb Martyna Michalska Natalia Karska Sylwia Rodziewicz-Motowido Konrad Szustakiewicz 《International journal of molecular sciences》2021,22(24)
In this research, we describe the properties of three-component composite foam scaffolds based on poly(ε-caprolactone) (PCL) as a matrix and hydroxyapatite whiskers (HAP) and L-Lysine as fillers (PCL/HAP/Lys with wt% ratio 50/48/2). The scaffolds were prepared using a thermally induced phase separation technique supported by salt leaching (TIPS-SL). All materials were precisely characterized: porosity, density, water uptake, wettability, DSC, and TGA measurements and compression tests were carried out. The microstructure of the obtained scaffolds was analyzed via SEM. It was found that the PCL/HAP/Lys scaffold has a 45% higher Young’s modulus and better wettability compared to the PCL/HAP system. At the same time, the porosity of the system was ~90%. The osteoblast hFOB 1.19 cell response was also investigated in osteogenic conditions (39 °C) and the cytokine release profile of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α was determined. Modification of PCL scaffolds with HAP and L-Lysine significantly improved the proliferation of pre-osteoblasts cultured on such materials. 相似文献
67.
Rafa Maka Pawel Janas Karolina Sapo Teresa Janas Tadeusz Janas 《International journal of molecular sciences》2021,22(17)
RNA motifs may promote interactions with exosomes (EXO-motifs) and lipid rafts (RAFT-motifs) that are enriched in exosomal membranes. These interactions can promote selective RNA loading into exosomes. We quantified the affinity between RNA aptamers containing various EXO- and RAFT-motifs and membrane lipid rafts in a liposome model of exosomes by determining the dissociation constants. Analysis of the secondary structure of RNA molecules provided data about the possible location of EXO- and RAFT-motifs within the RNA structure. The affinity of RNAs containing RAFT-motifs (UUGU, UCCC, CUCC, CCCU) and some EXO-motifs (CCCU, UCCU) to rafted liposomes is higher in comparison to aptamers without these motifs, suggesting direct RNA-exosome interaction. We have confirmed these results through the determination of the dissociation constant values of exosome-RNA aptamer complexes. RNAs containing EXO-motifs GGAG or UGAG have substantially lower affinity to lipid rafts, suggesting indirect RNA-exosome interaction via RNA binding proteins. Bioinformatics analysis revealed RNA aptamers containing both raft- and miRNA-binding motifs and involvement of raft-binding motifs UCCCU and CUCCC. A strategy is proposed for using functional RNA aptamers (fRNAa) containing both RAFT-motif and a therapeutic motif (e.g., miRNA inhibitor) to selectively introduce RNAs into exosomes for fRNAa delivery to target cells for personalized therapy. 相似文献
68.
Karolina Siewiera Magdalena Labieniec-Watala Nina Wolska Hassan Kassassir Cezary Watala 《International journal of molecular sciences》2021,22(17)
Blood platelets are considered as promising candidates as easily-accessible biomarkers of mitochondrial functioning. However, their high sensitivity to various stimulus types may potentially affect mitochondrial respiration and lead to artefactual outcomes. Therefore, it is crucial to identify the factors associated with platelet preparation that may lead to changes in mitochondrial respiration. A combination of flow cytometry and advanced respirometry was used to examine the effect of blood anticoagulants, the media used to suspend isolated platelets, respiration buffers, storage time and ADP stimulation on platelet activation and platelet mitochondria respiration. Our results clearly show that all the mentioned factors can affect platelet mitochondrial respiration. Briefly, (i) the use of EDTA as anticoagulant led to a significant increase in the dissipative component of respiration (LEAK), (ii) the use of plasma for the suspension of isolated platelets with MiR05 as a respiration buffer allows high electron transfer capacity and low platelet activation, and (iii) ADP stimulation increases physiological coupling respiration (ROUTINE). Significant associations were observed between platelet activation markers and mitochondrial respiration at different preparation steps; however, the fact that these relationships were not always apparent suggests that the method of platelet preparation may have a greater impact on mitochondrial respiration than the platelet activation itself. 相似文献
69.
Karolina Labus 《Materials science & engineering. C, Materials for biological applications》2012,32(2):228-235
Laccase and tyrosinase were immobilized by adsorption and covalent attachment onto microfiltration membranes made of cellulosic and polyamide material. Amine, hydroxyl and carboxylic functional groups for covalent attachment were generated by plasma polymerization of allylamine, allyl alcohol and acrylic acid using mild plasma parameters. Mass analysis of the modified membranes, surface tension and FTIR-ATR spectra were used to show the presence of stable plasma polymer on the membrane surface. It was shown that untreated and plasma treated cellulosic membranes were unsuitable for laccase and tyrosinase immobilization. Both, immobilization of laccase onto polyamide membrane modified with AlNH2 and adsorption on the untreated membrane at pH 5.2 gave satisfactory and comparable results with better operational stability in 10 consecutive batch processes for covalently bound enzyme. In the case of tyrosinase, adsorption of the enzyme on the untreated PA at pH 7.0 was as effective as covalent binding onto PA-AlNH2 (in pH 7.0). Operational stability was tested in the presence of diphenolic substrate, which exhibits strong suicide inactivation towards the enzyme. It was shown that immobilized tyrosinase seems to be exceptionally stable in the presence of diphenolic substrate. 相似文献
70.
Miroslaw Karbowniczek Elzbieta Kawecka-Cebula Jan Reichel 《Metallurgical and Materials Transactions B》2012,43(3):554-561
The most up-to-date trends in stainless steel production??aiming at the reduction of production costs??consist of the substitution of steel scrap by hot metal, coming from the reduction of iron-chromium ores. This process requires a more extensive dephosphorization. The dephosphorization process, when applied to chromium steels, requires slag with high dephosphorization properties, as either chromium or chromium oxide entering the slag decreases distinctly the efficiency of the process. The results of laboratory investigations on the dephosphorization of liquid iron solutions containing chromium and nickel are presented. In particular, the study was focused on the selection of the optimal slag composition and the way the slag should be added. The slags based on calcium and fluorite with cryolite additions were considered. It was shown that the variables with the greatest impact on the dephosphorization process include chromium and nickel levels, temperature, and slag basicity. A statistical analysis was performed and regression equations were set. The results may be of use for the design of new methods of production of high-chromium steels. 相似文献