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71.
L Sanjuanbenito A Esteban E González-Martinez 《Canadian Metallurgical Quarterly》1976,34(1-4):203-214
From a clinical standpoint recovery of spinal nerve roots is less likely than that of peripheral nerves, despite their identical structures. This may be due to several factors including the length of gap to be bridged, changes in the proximal stump or neuroma, and chromatolysis. In this paper we discuss the roles of some of these factors in relation to the neuronal depopulation in the spinal cord anterior horn area following section of the anterior root. The lack of growth or the successful growth of the axon through the gap in the root influences the degree of depopulation in the anterior horn area. 相似文献
72.
73.
A. Esteban M. L. Abarca M. R. Bragulat F. J. Caba es 《Food Additives & Contaminants》2006,23(6):616-622
The effect of pH (2-10) on growth and ochratoxin A (OTA) production by 12 Aspergillus niger aggregate strains was studied in two culture media: Czapek yeast autolysate agar (CYA) and yeast extract sucrose agar (YES), over 30 days. The strains were selected to include different sources, different reported abilities to produce OTA and different ITS-5.8S rDNA RFLP patterns. YES was a better culture medium than CYA for OTA production. In this medium, OTA was produced from pH 2 or 3 to 10 depending on the strain. The results show the ability of A. niger aggregate strains not only to grow, but also to produce OTA over a wide pH range. The results will lead to a better understanding of the role of A. niger aggregate strains in the OTA contamination of several food commodities. 相似文献
74.
75.
JA Pérez Arbej C Guinda Sevillano F Arnaiz Esteban E Martínez Pérez MA Nogueras Gimeno R Espuela Orgaz 《Canadian Metallurgical Quarterly》1995,19(3):243-246
Plasminogen activator inhibitor-1 (PAI-1), an important risk factor for thrombotic diseases, is a member of the superfamily of serine proteinase inhibitors. To define structural rearrangements occurring during interaction between PAI-1 and its target proteinases we have raised monoclonal antibodies against the PAI-1/t-PA complex. Thirteen out of 401 monoclonal antibodies reacted preferentially with the PAI-1/t-PA complex as compared to free PAI-1 or free t-PA. Detailed characterization revealed the presence of two non-overlapping neoantigenic epitopes in the PAI-1/t-PA complex. Both neoantigenic epitopes were also exposed after complex formation between PAI-1 and either urokinase-type plasminogen activator, plasmin or thrombin as well as after cleavage of the reactive site loop of non-inhibitory substrate type PAI-1 variants. Thus, we have identified two neoantigenic epitopes, localized entirely in PAI-1, and commonly exposed after complex formation of active PAI-1 with various proteinases or after cleavage of substrate PAI-1. These monoclonal antibodies should facilitate further studies on the mechanism of interaction between various PAI-1 forms and its target proteinases. 相似文献
76.
p53 mutation are currently recognized as the commonest genetic event in human tumors. In this paper are studied, through immunochemistry, the p53 protein expression of 25 carriers from squamous cell carcinoma of the larynx and hypopharynx as well in the non tumoral mucosa of the larynx removed and corresponding metastases. Because of the great overexpression of this protein among tumors and its metastases, aside with the low expression in normal far-off mucous membranes of the studied growths, the AA. draw out the conclusion that p53 mutation is a late event by neck and head oncogenesis. 相似文献
77.
Two different forms of hereditary amyotrophic lateral sclerosis (ALS) has been separated according to duration of illness. A rapid course with short survival as seen in sporadic ALS is usual, but a comparatively benign type with a mean survival of 12 years has been reported in some families. Four patients from an ALS-afflicted family with five affected members in three generations were examined and then followed up. A conspicuous variability in progression among the patients was observed, with death occurring from 26 months to 12 years after onset; one patient is alive 13 years after onset. Wide differences were also found with respect to initial site of involvement and pyramidal tract signs. Three other families with this mixed pattern of prognosis have been reported previously. Affected individuals within involved families had either short or long duration of the disease, rather than displaying a continuum. However, in view of the existence of a type of hereditary ALS with marked intrafamilial variability, prognosis, even in the presence of previous benign cases, should be cautiously given. 相似文献
78.
Antonio A. Caminos Rafiqul Gani Esteban A. Brignole 《Computers & Chemical Engineering》1984,8(2):127-136
A steady state liquid-liquid extractor model using the UNIFAC group contribution method for phase equilibria has been developed. A heuristic method, which limits the number of stage calculations per iteration to a low number is used, according to the residuals calculated in the previous iteration, the method either selects or rejects a stage for the calculations. With this approach, the same accuracy in results have been obtained at about half the computing time with respect to without use of heuristic method. The model has been applied to simulate staged extractors as well as continuous extractors (plate columns). The model is based on a very robust flash calculation routine and on a versatile package (UNIFAC) for the prediction of thermodynamic properties. 相似文献
79.
80.
Pedreira P Esteban L Criado AR Acedo P Sánchez M Sánchez J 《The Review of scientific instruments》2010,81(10):10D517
A high spatial resolution two color [CO(2), λ=10.6?μm/Nd:YAG (Nd:YAG denotes neodymium-doped yttrium aluminum garnet), and λ=1.064?μm] expanded-beam multichannel heterodyne interferometer has been installed on the TJ-II stellarator. Careful design of the optical system has allowed complete control on the evolution of both Gaussian beams along the interferometer, as well as the evaluation and optimization of the spatial resolution to be expected in the measurements. Five CO(2) (measurement) channels and three Nd:YAG (vibration compensation) channels have been used to illuminate the plasma with a probe beam of 100 mm size. An optimum interpolation method has been applied to recover both interferometric phasefronts prior to mechanical vibration subtraction. The first results of the installed diagnostic are presented in this paper. 相似文献