脱水导致的某些特殊疼痛

医学上的很多疾病都是我们无意识地进入脱水状态所致,因为身体最终会把缺水这一局面,通过某种奇特而确凿的方式显示出来。例如我们已谈过的胃灼热、胃痛等。以下疼痛也与缺水有关。     

脱水 让身体面临危机

关节脱水的后果如果关节脱水,软骨细胞就会处于强烈的摩擦状态,从而使它们迅速死亡,而死亡的细胞需要得到替换。软骨使用过度,并且处在修复状态,它就可能受到损伤,这一区域的感应器就会发出强烈的信号,表达它们急需修理的愿望。     

Multicamera people tracking with a probabilistic occupancy map

Given two to four synchronized video streams taken at eye level and from different angles, we show that we can effectively combine a generative model with dynamic programming to accurately follow up to six individuals across thousands of frames in spite of significant occlusions and lighting changes. In addition, we also derive metrically accurate trajectories for each one of them.Our contribution is twofold. First, we demonstrate that our generative model can effectively handle occlusions in each time frame independently, even when the only data available comes from the output of a simple background subtraction algorithm and when the number of individuals is unknown a priori. Second, we show that multi-person tracking can be reliably achieved by processing individual trajectories separately over long sequences, provided that a reasonable heuristic is used to rank these individuals and avoid confusing them with one another.     

Isoform-specific expression and characterization of 14-3-3 proteins in human glioma tissues discovered by stable isotope labeling with amino acids in cell culture-based proteomic analysis

Human 14-3-3 proteins have isoform-specific expression and functions in different kinds of normal or tumor cells and tissues. However, the expression profiling of 14-3-3 proteins and isoform-specific biological functions are unclear in human glioma so far. In our study, the expression levels and characterization of 14-3-3 isoforms in human glioma tissues were investigated by a sensitive, accurate stable isotope labeling with amino acids in cell culture-based quantitative proteomic strategy. As a result, except unexpressed 14-3-3σ, the other six isoforms, with different expression levels, were existed in glioma tissues and para-cancerous brain tissues (PBTs). 14-3-3β and η were upregulated, whereas 14-3-3ζ was downregulated in glioma tissues compared with that in PBTs. And the other three isoforms 14-3-3ε, θ, and γ had similar expression levels in human glioma tissues and PBTs. Western blot and immunohistochemistry analysis were both consistent with the quantitative proteomic data. The loss of expression of 14-3-3σ was further discovered due to DNA high methylation in its coding region in glioma by methylation-specific PCR analysis. These results indicated that the four isoforms, including 14-3-3β, η, ζ, and σ, may play important roles in tumorigenesis of human glioma, which is probably used as potential biomarkers for diagnosis and targets for treatment of human gliomas in future.     

Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Multiple sclerosis is characterized by inflammatory demyelination and axonal loss as pathophysiological correlates of relapsing activity and progressive development of clinical disability. The molecular processes involved in this pathogenesis are still unclear as they are quite complex and heterogeneous. In this article we present protein expression analysis of brain and spinal cord tissues from different models of murine experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model for multiple sclerosis. We observed a number of EAE-specific protein expression and PTM differences. Proteome analysis was extended to multiple sclerosis specimens in order to validate the EAE findings. Our findings suggest the regulation of a number of proteins that shed light on the molecular mechanisms of the disease processes taking place in EAE and multiple sclerosis. We found consistent modulation of proteins including serum amyloid P component, sirtuin 2, dihydropyrimidinase-related protein family proteins, stathmin 1, creatine kinase B and chloride intracellular channel protein 1. Functional classification of the proteins by database and the literature mining reveals their association with neuronal development and myelinogenesis, suggesting possible disease processes that mediate neurodegeneration.     

Phase-retardation and full-polarization analysis of soft-x-ray synchrotron radiation close to the carbon K edge by use of a multilayer transmission filter

We have produced a multilayer transmission filter with 100 periods of Cr/C to achieve a significant phase retardation while maintaining good transmission for photon energies just below the carbon K edge. This device was installed into a polarimeter behind the SX700/3 monochromator at the Berlin synchrotron radiation laboratory, BESSY. The phase-retardation properties were observed as theoretically predicted. Agreement between experiment and calculation could be obtained by introduction of a rather small interface roughness in the simulation code (σ = 0.65 nm rms). An observed phase retardation of 5° was sufficient to permit, for the first time we believe, a complete and unambiguous polarization analysis of soft-x-ray synchrotron radiation (265-eV photon energy) with primary standards.     

Admittance of rugate filters derived from a 2 × 2 inhomogeneous matrix

Admittance diagrams are used to analyze qualitatively and quantitatively the behavior of inhomogeneous thin films with an arbitrary refractive-index function. From this study it follows that one can treat the behavior of rugate filters by using the concept of effective refractive indices, which are associated with the phase integral in a simple way. These results are applied to the study of periodic systems, and, as expected, one can consider high and low effective refractive indices to determine the important parameters of these stop bands. With these ideas it is possible that one can deal with rugate filters more closely as homogeneous periodic systems by taking advantage of the existing theory.     

Infrared optical constants of polycrystalline boron nitride: reply to comment

This reply is to the comment by C. G. Ribbing [Appl. Opt. 33, 8055 (1994)] on our paper on IR optical constants of polycrystalline boron nitride.