Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight

Primary aldosteronism (PA) is a pathological condition characterized by an excessive aldosterone secretion; once thought to be rare, PA is now recognized as the most common cause of secondary hypertension. Its prevalence increases with the severity of hypertension, reaching up to 29.1% in patients with resistant hypertension (RH). Both PA and RH are “high-risk phenotypes”, associated with increased cardiovascular morbidity and mortality compared to non-PA and non-RH patients. Aldosterone excess, as occurs in PA, can contribute to the development of a RH phenotype through several mechanisms. First, inappropriate aldosterone levels with respect to the hydro-electrolytic status of the individual can cause salt retention and volume expansion by inducing sodium and water reabsorption in the kidney. Moreover, a growing body of evidence has highlighted the detrimental consequences of “non-classical” effects of aldosterone in several target tissues. Aldosterone-induced vascular remodeling, sympathetic overactivity, insulin resistance, and adipose tissue dysfunction can further contribute to the worsening of arterial hypertension and to the development of drug-resistance. In addition, the pro-oxidative, pro-fibrotic, and pro-inflammatory effects of aldosterone may aggravate end-organ damage, thereby perpetuating a vicious cycle that eventually leads to a more severe hypertensive phenotype. Finally, neither the pathophysiological mechanisms mediating aldosterone-driven blood pressure rise, nor those mediating aldosterone-driven end-organ damage, are specifically blocked by standard first-line anti-hypertensive drugs, which might further account for the drug-resistant phenotype that frequently characterizes PA patients.     

Transitions in Presence of Short Laser Pulses

Abstract

Accurate numerical calculations are carried out to investigate the validity of the two-state approximation in the case of resonant interactions between electromagnetic radiation and atoms. Short pulses are considered and the presence of the atomic spectrum is modelled by introducing a third, non-resonant, state. We show that the harmonics of the pulse profile may play a significant role in the dynamics of the process and may cause energy non-conserving transitions between the atomic states.     

A three dimensional exact equation for the turbulent dissipation rate of Generalised Newtonian Fluids

The flow of non-Newtonian fluids is of interest in many biological and industrial applications, including nanofluids. Most of the papers of the literature on turbulent non-Newtonian fluids focused the attention on viscoelastic fluids. In order to make accurate and low cost prediction of turbulent inelastic non-Newtonian fluids, a RANS Generalised Newtonian Fluid (GNF) turbulence model, based on the exact equations for the turbulent variables, is required. In a previous paper of the same authors the exact equations for the turbulent kinetic energy and the dissipation rate have been derived in a two-dimensional (2D) domain, through the introduction of an apparent viscosity equation. The aim of the present paper is to extend the approach to a three-dimensional (3D) domain, giving the full mathematical demonstration of the exact equations.     

Thermal–economic–environmental analysis and multi-objective optimization of an internal-reforming solid oxide fuel cell–gas turbine hybrid system

In this article, an internal-reforming solid oxide fuel cell–gas turbine (IRSOFC–GT) hybrid system is modeled and analyzed from thermal (energy and exergy), economic, and environmental points of view. The model is validated using available data in the literature. Utilizing the genetic algorithm optimization technique, multi-objective optimization of modeled system is carried out and the optimal values of system design parameters are obtained. In the multi-objective optimization procedure, the exergy efficiency and the total cost rate of the system (including the capital and maintenance costs, operational cost (fuel cost), and social cost of air pollution for CO, NO_x, and CO₂) are considered as objective functions. A sensitivity analysis is also performed in order to study the effect of variations of the fuel unit cost on the Pareto optimal solutions and their corresponding design parameters. The optimization results indicate that the final optimum design chosen from the Pareto front results in exergy efficiency of 65.60% while it leads to total cost of 3.28 million US$ year⁻¹. It is also demonstrated that the payback time of the chosen design is 6.14 years.     

Optimal control with constrained total variance for Markov jump linear systems with multiplicative noises

We consider in this paper the stochastic optimal control problem of discrete-time linear systems subject to Markov jumps and multiplicative noises (MJLS-mn for short). Our objective is to present an optimal policy for the problem of maximising the system's total expected output over a finite-time horizon while restricting the weighted sum of its variance to a pre-specified upper-bound value. We obtain explicit conditions for the existence of an optimal control law for this problem as well as an algorithm for obtaining it, extending previous results in the literature. The paper is concluded by applying our results to a portfolio selection problem subject to regime switching.     

Synthesis and characterization of conjugated polymers for the obtainment of conductive patterns through laser tracing

This article describes the preparation of thin films of conjugated polymers which can enhance their specific electrical conductivity by several orders of magnitude by changing their state from insulating to conducting materials. The examined polymers, i.e., a polyacetylenic and a polythiophenic derivative, are functionalized with thioalkylic side chains and are soluble in common organic solvents from which they lead to thick homogeneous films. The films can be deposited on different substrates, either rigid or flexible, and can be easily exposed to laser radiation to make them conductive. The process is irreversible, and the final conductivity is stable over time, even in the presence of high temperatures (up to 180 °C), moisture, and air. The high stability of treated samples, easy polymer synthesis and quick and inexpensive suitably tailored laser tracing procedure make these materials very promising for applications in organic electronics and in the development of new electronic circuitry.     

Effect of sugar, citric acid and egg white type on the microstructural and mechanical properties of meringues

Meringues are characterized by a predominant air phase and their overall quality is intimately related with microstructure. The formation of meringues microstructure relies on the capacity of egg white (EW) proteins to form voluminous and stable foams and it is ultimately related with the chemical properties of proteins and with the addition of ingredients such as sugars, salts, acids and surfactants.The study aimed at assessing the influence of sugar/EW ratio, citric acid and EW type on the microstructural and mechanical properties of meringues. Meringues prepared with different sugar/EW, citric acid level and different EW type were subjected to microstructural analysis by X-ray microtomography and to mechanical assessment by compression tests.Results demonstrate the ability of X-ray microtomography to reconstruct the 3D microstructure of meringues allowing the measurement of porosity, size, shape and distribution of pores. Citric acid, sugar concentration and EW type play a fundamental role on meringues microstructural parameters and mechanical properties. Low sugar/EW ratios as well as increasing citric acid levels increase the air phase and result in a softer texture of meringues. Moreover, low sugar/EW ratios and increasing citric acid in the meringue result in a reduction of pore size and also influence the shape of pores. Meringues microstructural and mechanical properties are affected by the EW quality: fresh and pasteurized EWs and EWs stored at refrigerated temperatures scored the highest structural and mechanical performances, while powdered and frozen EWs and albumens from old eggs showed the worst results. Not only the balance among ingredients but also the choice of raw materials can strongly affect the final quality of meringues.     

Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib

Among the phenolic acids tested on the K562 cell line, a model of chronic myeloid leukemia (CML), caffeic acid (CA) was biologically active on sensitive and imatinib (IM)-resistant cells at micro-molar concentration, either in terms of reduction of cell proliferation or triggering of apoptosis. The CA treatment provoked mitochondrial membrane depolarization, genomic DNA fragmentation and phosphatidylserine exposure, hallmarks of apoptosis. Cell cycle analysis following the treatment with comparable cytotoxic concentrations of IM or CA showed marked differences in the distribution profiles. The reduction of cell proliferation by CA administration was associated with increased expression of two cell cycle repressor genes, CDKN1A and CHES1, while IM at a cytotoxic concentration increased the CHES1 but not the CDKN1A expression. In addition, CA treatment affected the proliferation and triggered the apoptosis in IM-resistant cells. Taken together, these data suggested that CA induced the anti-proliferative effect and triggered apoptosis of CML cells by a different mechanism than IM. Finally, the combined administration of IM and CA at suboptimal concentrations evidenced a synergy of action in determining the anti-proliferative effect and triggering apoptosis. The ability of CA to potentiate the anti-leukemic effect of IM highlighted the nutraceutical potential of CA in CML.     

3D floor plan recovery from overlapping spherical images

Computational Visual Media - We present a novel approach to automatically recover, from a small set of partially overlapping spherical images, an indoor structure representation in terms of a 3D...     

Studying Formability Limits By Combining Conventional and Incremental Sheet Forming Process

In this work it is assessed the potential of combining conventional and incremental sheet forming processes in a same sheet of metal.This so-called hybrid forming approach is performed through the manufacture of a pre-forming by conventional forming,followed by incremental sheet forming.The main objective is analyzing strain evolution.The pre-forming induced in the conventional forming stage will determine the strain paths,directly influencing the strains produced by the incremental process.To conduct the study,in the conventional processes,strains were imposed in three different ways with distinct true strains.At the incremental stage,the pyramid strategy was adopted with differ-ent wall slopes.From the experiments,the true strains and the final geometries were analyzed.Numerical simulation was also employed for the sake of comparison and correlation with the measured data.It could be observed that single-stretch pre-strain was directly proportional to the maximum incremental strains achieved,whereas samples subjected to biaxial pre-strain influenced the formability according to the degree of pre-strain applied.Pre-strain driven by the prior deep-drawing operation did not result,in this particular geometry,in increased formability.