Uterine relaxation responses to calcitonin gene-related peptide and calcitonin gene-related peptide receptors decreased during labor in rats

OBJECTIVES: Our purpose was to investigate (1) whether uterine relaxation responses to calcitonin gene-related peptide are differentially regulated during pregnancy and labor, (2) the involvement of nitric oxide in smooth muscle relaxant action of calcitonin gene-related peptide in the rat uterus, (3) whether receptors for calcitonin gene-related peptide are expressed in rat uterus, and if so (4) whether the concentrations of these receptors are differently regulated during pregnancy and labor. STUDY DESIGN: Rats were killed on day 18 of gestation, at the time of spontaneous labor, or postpartum day 2. The uteri were removed for in vitro contractility measurements, nitric oxide production, and calcitonin gene-related peptide receptor binding assay. RESULTS: (1) Calcitonin gene-related peptide induced a dose-dependent relaxation in spontaneously contracting uterine strips from pregnant rats on day 18 of gestation; (2) the relaxation effects of calcitonin gene-related peptide on the uterus were decreased during spontaneous delivery at term and post partum compared with that during pregnancy; (3) calcitonin gene-related peptide-induced relaxation was inhibited by pretreatment of the uterine tissue with a calcitonin gene-related peptide receptor antagonist, calcitonin gene-related peptide(8-37); (4) nitric oxide synthesis inhibitor (N(G)-nitro-L-arginine methyl ester) and soluble guanylate cyclase inhibitor (LY83583) significantly decreased calcitonin gene-related peptide-induced relaxation of the rat uterus during pregnancy; (5) calcitonin gene-related peptide increased the uterine nitric oxide production in pregnant rats, and this increase was obliterated in the presence of calcitonin gene-related peptide(8-37); and (6) calcitonin gene-related peptide receptors are present in rat uterus, and the concentration of these receptors dramatically increases during pregnancy and decreases during labor at term. CONCLUSIONS: Calcitonin gene-related peptide inhibits uterine spontaneous contractions in rats during pregnancy but not during labor and post partum. The inhibitory effects of calcitonin gene-related peptide on uterine contractility appear to be modulated, at least in part, by the activation of nitric oxide generation in the rat uterus. Changes in calcitonin gene-related peptide receptors could contribute to the changes in calcitonin gene-related peptide-mediated uterine relaxation during pregnancy and labor.     

确定型存贮模型的系统动态描述

本文尝试用系统动态学的研究方法于存贮理论，建立确定型存贮问题的系统动态优化模型，并对模型作了数学推导。     

EC与~（99m）Tc－GH之间的配体交换反应动力学研究

实验表明，ＥＣ浓度与配体交换反应速度常数无关，体系的ｐＨ值对速度常数和９９ｍＴｃ－ＥＣ的标记率影响较大。测定并计算了不同ｐＨ值的交换反应速度常数。结果表明，为保证用配体交换法制备９９ｍｃ－ＥＣ时９９ｍｃ－ＥＣ的标记率大于９０％，体系的ｐＨ值必须≥８。     

气浮池──稳定塘处理造纸废水

叙述了用气浮地→厌氧塘→兼性塘处理造纸废水的试验与设计。经运行后测定，出水达到了天津市水污染物排放标准的要求。气浮池采用３０％的回流比，提高了处理效率，每天可回收纸板原料８．４～１０．８ｔ。     

表面微观屈服应力与表面变形研究

本文对表面微观屈服应力的测量与计算方法及表面变形的应变曲线进行了分析研究。结果表明，表面微观屈服应力与加载方式有关；表面变形的应力应变曲线具有双线性特征。     

A MODEL OF A PYROLYSIS GASIFIER FOR PREDICTION COMPOSITIONS AND FLOU RATE OF PRODUCED GAS

A model of pyrolysis gasifier, which is mainly composed of a pyrolysis, a cracking and a combustion chamber, it developed to predict its performance parameters and to simulate its operation. Toe model consists of a pyrolysis-cracking sub-model, a secondary gasification sub-model and a combustion sub- model, of which the pyrolysis-cracking sub-model is modified to predict components of tbe pyrolysis gas. Then, It with the other two sub-models can predict components, heating value and flow rate of the produced gas, thermal efficiency and total energy efficiency of the gasifier as ell. Crank-Nicolson Scheme (half implicit difference formulation) in which the time step is not confined by stability and the cutting error is small, is applied to solving the model whose differential equations are nonlinear and have no analytic solution. Theo, the nonlinear difference algebraic equations are solved by interalions, which requires less storage of computer. Underrelaxation is applied to avoiding divergence of Causs-Seidel interations. Finally, the simulated results are input to Software Lotus 1-2-3, by which the results are printed and graphed so as to compare with the experimental ooes, and it shots acceptable agreement, thus validate the model.     

Chemical constituents of Luffa cylindrica (L.) Roem

Six compounds were isolated from the fruits of Luffa cylindrica. They were identified as lucyosides C, E, F, H, a mixture of alpha-spinasterol and stigmasta-7,22,25-trien-3 beta-OH and a mixture of alpha-spinasteryl glucoside and delta 7,22,25-stigmasteryl-beta-D-glucoside by means of chemical evidence and spectral analysis.     

多级防火墙技术研究与应用探讨

在计算机信息技术和互联网飞速发展的今天,互联网在人类的生活、工作、学习中占据着重要地位。然而计算机网络安全是其与之俱来不可避免的问题。本文将基于多级防火墙技术,分析当前计算机网络中存在的安全隐患,针对这些实际问题探讨如何有效应用多级防火墙技术,实现对计算机网络安全的维护。     

视频会议管理系统的研究及实现

通过对浙江中烟视频会议系统现状、业务流程及业务实际的分析,提出了以软件形式统一管控的会议操作、网络监测和流程管控的管理模式,并对软件架构和实现方式进行了详细阐述。通过该套软件的开发部署,实现了管理与使用分离,达到了简便管理、提高效率、减少故障的目的,取得了良好的效果。     

几种插值算法的比较研究

在图像放大处理中,一般都会用到插值算法,为了实时性的要求,在保证放大效果的基础上,希望插值算法尽可能简单。插值指利用某一个函数来计算出2个或更多的值之间的值。文中就常用的NEDI、DUBE、9-Direction、KR（kernel re-gression）等的理论基础和算法原理做了分析,通过采用四种插值算法对图像进行缩放处理操作,可以直观比较它们处理后的效果。文中使用matlab仿真工具分别就这四种算法对典型的lena、flower和night图像进行了处理,并对它们的处理结果加以比较,最后总结了四种算法各自的特点。