主板行情

就在所有人都认为P965将是“扣肉”的最佳搭配并延续当年i865PE的辉煌时，却突然爆出P965存在FMA内存兼容性问题的消息。现在，Intel已经将P965北桥从C1步进提高到C2步进，因此消费者在购买P965主板时都格外小心。     

主板行情

在nVIDIA收购ULi之后，很多人都在怀疑ATi在芯片组市场的决心，然而KD580芯片组的推出终结了一切谣言。这款芯片组能够支持双PCI-E&;#215;16枝术，此时很好地配合交火技术而达到出色的性能，帮助ATi在综合平台竞争中不落后于nVIDIA。此外，ATi还开始积极研发自家的南桥芯片，摆脱对其他芯片组厂商的依赖．     

Approximation Algorithms for Scheduling with Reservations

We study the problem of non-preemptively scheduling n independent sequential jobs on a system of m identical parallel machines in the presence of reservations, where m is constant. This setting is practically relevant because for various reasons, some machines may not be available during specified time intervals. The objective is to minimize the makespan C _max, which is the maximum completion time.     

P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory cytokines or the modulation of cell death. P2X7 also exhibit unique behaviors, such as “macropore” formation, which corresponds to enhanced large molecule cell membrane permeability and current facilitation, which is caused by prolonged activation. These two phenomena have often been confounded but, thus far, no clear mechanisms have been resolved. Here, by combining different approaches including whole-cell and single-channel recordings, pharmacological and biochemical assays, CRISPR/Cas9 technology and cell imaging, we provide evidence that current facilitation and macropore formation involve functional complexes comprised of P2X7 and TMEM16, a family of Ca²⁺-activated ion channel/scramblases. We found that current facilitation results in an increase of functional complex-embedded P2X7 open probability, a result that is recapitulated by plasma membrane cholesterol depletion. We further show that macropore formation entails two distinct large molecule permeation components, one of which requires functional complexes featuring TMEM16F subtype, the other likely being direct permeation through the P2X7 pore itself. Such functional complexes can be considered to represent a regulatory hub that may orchestrate distinct P2X7 functionalities.     

Clinical validation of the Chinese Personality Assessment Inventory.

The clinical validity of the Chinese Personality Assessment Inventory (CPAI; F. M. Cheung, K. Leung, et al., 1996) was examined in 2 studies involving a group of 167 male prisoners in Hong Kong and a group of 339 psychiatric patients in China. Elevated scores on the clinical scales were obtained for the clinical samples. Logistic regression analyses confirmed that the CPAI scales were useful in differentiating between male prisoners and the Hong Kong male normative sample and between psychiatric patients and a random sample of normal adults in China. Multivariate analyses of variance results showed significant differences on the CPAI clinical scales and personality scales among subgroups of psychiatric patients with diagnoses of bipolar, schizophrenic, and neurotic disorders. The usefulness of an indigenous personality inventory is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Different ways for grafting ester derivatives of poly(ethylene glycol) onto chitosan: related characteristics and potential properties

The grafting of poly(ethylene glycol) functionalized by ester groups (MeO-PEG-ester) onto chitosan was studied and optimized using different reaction conditions. In a first procedure, the grafting was made from 6-O-triphenylmethyl-chitosan after protection of primary hydroxyl groups and in a second one, it was made directly onto chitosan. NMR spectroscopy was an important tool to study these reactions and the grafting is unequivocally showed up. Moreover, for each procedure, the solubility and surface properties of the obtained copolymers were evaluated and compared.     

Standardization of the Chinese MMPI–A in Hong Kong: A preliminary study.

The Chinese Minnesota Multiphasic Personality Inventory—Adolescents (MMPI—A) was applied in Hong Kong to a normative sample of 565 male and 664 female students ages 14–18. The Chinese adolescents' MMPI–A T scores based on the U.S. adolescent norms were elevated more than 1 SD on Scale 2. Similar elevations were found on Scale L (Lie) for the female students and on Scale A-lse (Adolescent Low Self-Esteem) for the male students. Moderate elevations were also shown on several scales, although none of the clinical scales exceeded a T score of 65, the clinical cutoff point based on U.S. norms. Whether these elevations were due to cultural differences in item interpretation or higher levels of psychopathology among the Hong Kong students cannot be concluded from the present data. However, previous findings on the Chinese MMPI favors the former explanation. These cultural differences should be taken into consideration in clinical interpretations of elevated scores on the Chinese MMPI—A. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Novel Heterobimetallic Radiotheranostic: Preparation,Activity, and Biodistribution

A novel Ru^II(arene) theranostic complex is presented. It is based on a 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of ¹⁵³Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as ¹⁵³Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected for this type of metallodrug, and is nontoxic to the organism as a whole. As a proof of concept, initial studies in healthy mice were performed to obtain information about the uptake, biodistribution, and excretion of the radiolabeled complex.