Targeting Mucin Protein Enables Rapid and Efficient Ovarian Cancer Cell Capture: Role of Nanoparticle Properties in Efficient Capture and Culture

The development of specific and sensitive immunomagnetic cell separation nanotechnologies is central to enhancing the diagnostic relevance of circulating tumor cells (CTCs) and improving cancer patient outcomes. The limited number of specific biomarkers used to enrich a phenotypically diverse set of CTCs from liquid biopsies has limited CTC yields and purity. The ultra-high molecular weight mucin, mucin16 (MUC16) is shown to physically shield key membrane proteins responsible for activating immune responses against ovarian cancer cells and may interfere with the binding of magnetic nanoparticles to popular immunomagnetic cell capture antigens. MUC16 is expressed in ≈90% of ovarian cancers and is almost universal in High Grade Serous Epithelial Ovarian Cancer. This work demonstrates that cell bound MUC16 is an effective target for rapid immunomagnetic extraction of expressor cells with near quantitative yield, high purity and viability from serum. The results provide a mechanistic insight into the effects of nanoparticle physical properties and immunomagnetic labeling on the efficiency of immunomagnetic cell isolation. The growth of these cells has also been studied after separation, demonstrating that nanoparticle size impacts cell-particle behavior and growth rate. These results present the successful isolation of “masked” CTCs enabling new strategies for the detection of cancer recurrence and select and monitor chemotherapy.     

High-Performance Quasi-Solid-State Na-Air Battery via Gel Cathode by Confining Moisture

Rechargeable Na-air batteries are the subject of great interest because of their high theoretical specific energy density, lower cost, and lower charge potential compared with Li-air batteries. However, high purity O₂ as a working environment is required to achieve high-performance Na-air batteries, which obstructs their application as a high-energy-density battery. Although aqueous Na-air batteries can operate in ambient air, long cycle and high safety remain challenges for aqueous Na-air batteries because the aqueous electrolyte is volatile. Here, a quasi-solid-state Na-air battery is reported by utilizing a gel cathode, which is composed of single-walled carbon nanotubes and room-temperature ionic liquids, achieving high safety and long cycling life of 125 cycles (528 h) at a current density of 0.1 mA cm⁻², which is surprisingly better than that of quasi-solid-state Na O₂ batteries. In situ XRD characterizations reveal that water in ambient air is gradually deposited on the surface of the gel cathode to form a water layer, which facilitates the generation of soluble discharge product of NaOH thermodynamically with high conductivity. This work shall be critical to develop and promote the practical application of Na-air batteries, opening a new way to the design of solid-state metal-air batteries.     

Liver Transplantation for Colorectal Liver Metastases: Current Management and Future Perspectives

Patients with nonresectable liver metastases from colorectal cancer have few therapeutic options and a dismal prognosis. Although liver transplantation for this indication has historically a poor reputation, recent advances in the field of chemotherapy and immunosuppression have paved the way to revisit the concept. New data have shown promising results that need to be validated in several ongoing clinical trials. Since liver grafts represent a scarce resource, several new tools are being explored to expand the donor pool for this indication. The purpose of this review is to present all current available data and perspectives about liver transplantation for nonresectable liver metastases from colorectal cancer.     

Effect of gamma irradiation on the oxygen barrier properties in ethyl-vinyl acetate/ethylene-vinyl alcohol/ethyl-vinyl acetate multilayer film

The potential changes of single-use plastic materials (EVA/EVOH/EVA multilayer film in this study) used in biopharmaceutical and food-packaging industries are investigated after several gamma irradiation doses: 30, 50, 115, and 270 kGy, and for nonsterilized samples (0 kGy) from a point of view of mechanical properties, thermal properties and permeability properties. Tensile tests, differential scanning calorimetry (DSC), oxygen transmission rate (OTR) and water vapor transmission rate (WVTR) are performed on the multilayer film. For irradiation doses below 50 kGy, thermal and water vapor barrier properties are not altered. For higher doses (50 to 270 kGy), mechanical, thermal and water vapor barrier properties are slightly altered whereas oxygen barrier property decreases from 13 to 27 cm³.m⁻².day⁻¹. This slight change is shown not to happen due to chain entanglement or chain mobility loss in the amorphous phase of the different polymers. It rather comes from a change of the chemical environment of the EVOH layer.     

Optical,FTIR and DC Conductivity of Soda Lime Silicate Glass Containing Cement Dust and Transition Metal Ions

Four soda lime silicate glass samples of composition (70 % SiO₂+ 20 % Na₂O+ 10 % CaO mol %) were prepared after adding 5 wt% cement dust to each sample mixture besides 0.1 wt% of one transition metal (TM) oxide of Fe, Co or Cu. The four samples were melted by a conventional melt-annealing technique at 1400 ^°C for 2.5 h. Density, UV/VIS, FTIR and DC conductivity measurements were performed for each glass. Experimental results indicate that there are only slight differences in the density values. The optical spectra reveal that the TM free sample and the sample containing iron ions have the same spectral features while the samples containing copper or cobalt exhibit distinct characteristic absorption bands due to each TM ion. FTIR spectra reveal characteristic vibrational bands due to stretching and bending modes of the silicate network. DC conductivity data show variations in the values of the studied samples according to the type of TM ions added. All the experimental results were correlated with each other in accordance with the current views on the constitution of the studied glasses.     

CoolMOS CS服务器系列MOSFET:向理想开关迈进

前言 CoolMOS CS系列"超级结"MOSFET器件高压设备的成功是基于1998年英飞凌公司推出的CoolMOS技术.这些器件的优越性能实现了区域导通电阻的大幅度降低.     

蜂窝网还是WiFi网？

正如一句谚语所说“标准所带来的好处就在于它们的数量有那么多。”现今的世界是否还需要另一种说法呢?