Numerical simulation of cooling performance in microchannel heat sinks made of AlN ceramics

Microsystem Technologies - The problem of generating a high amount of heat in microelectronic equipment should be minimized properly. Allowing systems to run for long periods of time in high...     

Study the Effect of Surface Parameters Variation on the Corrosion Behavior of Thin Chromium Layer on Modified Titanium

Protection of Metals and Physical Chemistry of Surfaces - In this study, a thin chromium layer was applied on pure titanium substrate in a Sargent bath including 250 g/L chromic acid and 2.5 g/L...     

Studying the Role of Gelation Agents in Gelcasting Non-porous Si3N4 Bodies by Pressureless Sintering

Silicon - The monomer content in the gelcasting process affects the kinetics of cross-linking reactions which determines the quality of the gel network structure and the final properties of the...     

Inclusion complexes of atorvastatin calcium (ATV-Ca) and rosuvastatin calcium (ROV-Ca) drugs with α-CD, β-CD, γ-CD,HP-β-CD,M-β-CD,and maltodextrin along with their characterizations through experimental and computational methods

The aim of this research is a comparison of the efficiency of six commercially available cyclodextrins (CDs) to improve the solubility and oral bioavailability of atorvastatin calcium (ATV-Ca) and rosuvastatin calcium (ROV-Ca) drugs in aqueous media. Inclusion complexes of both drugs with non-toxic α-CD, β-CD, γ-CD, HP-β-CD, M-β-CD, and maltodextrin were prepared in a 1:1 stoichiometry via the kneading method. To reach the best CD, various experimental and computational analyses were performed including phase solubility, dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), atomic force microscopy (AFM), hydrogen-1 nuclear magnetic resonance (¹HNMR), carbon-13 nuclear magnetic resonance (¹³CNMR), and molecular docking calculations. The M-β-CD turned out to be the best substrate for the micro-encapsulation of both drugs. Also, ATV showed a higher tendency than ROV to form inclusion complexes with CDs. Molecular docking studies showed that HP–β–CD and M-β-CD are the most suitable substrates for the formation of inclusion complexes, respectively. Our research showed that the β-CD is not necessarily the most efficient substrate for increasing solubility based on previous reports in the literature; meanwhile, the other employed substrates in this study can show acceptable performances in this regard. According to our results, M-β-CD is the best substrate for the micro-encapsulation of both drugs, which increases their solubility in water.