保罗·安德鲁和他的匀质空间

保罗·安德鲁的建筑充分展现了丰富的几何形体创造,对结构的大胆运用和情感的有张有弛,在戴高乐机场的建设发展过程中,安德鲁个人的设计风格和直觉成为保持不同阶段的建设和谐统一的关键因素,由此创造出一种特有的艺术感受,在建筑内部随处可见。与其说他力图通过设计方案创造出一种明确的和谐统一感,不如说是一种不确定性,一种非现代的和风格化的感情意识。戴高乐机场为安德鲁后来在地理,经济和文化条件不同的其他地区的机场设计项目中继续其有关功能和风格的实践打下了基础。     

The frequency domain approach in virtual fatigue estimation of non-linear systems: The problem of non-Gaussian states of stress

The use of the frequency domain approach in the virtual estimation of mechanical component fatigue life under random loads is related to two conditions regarding the dynamic behaviour of components and the state of stress. The mechanical system must have linear behaviour and the probability density function of stress must be Gaussian, respectively. Obviously, these conditions are not independent, because there is a close tie between the transformations induced by the system to the random inputs and stress distribution.The rigorous procedure for the extension of these hypotheses is not available and only approximated approaches can be used: normally these are based on a corrective coefficient to the narrow-band formula.The main goal of this report is to suggest a separation of the effects on the corrective coefficient. In this manner, the global coefficient can be seen as the product between a partial coefficient related only to the wide-band effects of stress power spectral density function and another one dependent on non-normality indices of stress probability density function. A meaningful application has been investigated to validate the practical employment of this approach. By this example the authors also defined an original analytical expression of a corrective coefficient for Gaussian damage; however, the formulation has to be improved by other applications, because its validity is tested only on a too much limited domain of Kurtosis values. Moreover, the authors suggest that a modal approach to the stress recovery procedure of a flexible body might be an interesting way to the rapid identification of non-Gaussianity indices in the analysis of frequency and time domain dynamics. For this reason, they believe that the investigation of tying the stress non-Gaussianity to the non-Gaussianity of the component modal coordinates to be useful.     

Analysis of bibliometric indicators for individual scholars in a large data set

Citation numbers and other quantities derived from bibliographic databases are becoming standard tools for the assessment of productivity and impact of research activities. Though widely used, still their statistical properties have not been well established so far. This is especially true in the case of bibliometric indicators aimed at the evaluation of individual scholars, because large-scale data sets are typically difficult to be retrieved. Here, we take advantage of a recently introduced large bibliographic data set, Google Scholar Citations, which collects the entire publication record of individual scholars. We analyze the scientific profile of more than 30,000 researchers, and study the relation between the h-index, the number of publications and the number of citations of individual scientists. While the number of publications of a scientist has a rather weak relation with his/her h-index, we find that the h-index of a scientist is strongly correlated with the number of citations that she/he has received so that the number of citations can be effectively be used as a proxy of the h-index. Allowing for the h-index to depend on both the number of citations and the number of publications, we find only a minor improvement.     

A Bayesian paradox and its impact on the GUM approach to uncertainty

The paper presents ideas and observations about the use of the frequentist and the Bayesian approach to estimation and uncertainty. The merits and the pitfalls of the Bayesian approach, compared with the frequentist one, are illustrated using a simple example, which gives rise to an instructive paradox. The impact of the paradox on the GUM approach to uncertainty prescribed in Supplement 1 is highlighted and discussed.     

Assessment of intradialysis calcium mass balance by a single pool variable‐volume calcium kinetic model

Introduction: A reliable method of intradialysis calcium mass balance quantification is far from been established. We herein investigated the use of a single‐pool variable‐volume Calcium kinetic model to assess calcium mass balance in chronic and stable dialysis patients. Methods: Thirty‐four patients on thrice‐weekly HD were studied during 240 dialysis sessions. All patients were dialyzed with a nominal total calcium concentration of 1.50 mmol/L. The main assumption of the model is that the calcium distribution volume is equal to the extracellular volume during dialysis. This hypothesis is assumed valid if measured and predicted end dialysis plasma water ionized calcium concentrations are equal. A difference between predicted and measured end‐dialysis ionized plasma water calcium concentration is a deviation on our main hypothesis, meaning that a substantial amount of calcium is exchanged between the extracellular volume and a nonmodeled compartment. Findings: The difference between predicted and measured values was 0.02 mmol/L (range ?0.08:0.16 mmol/L). With a mean ionized dialysate calcium concentration of 1.25 mmol/L, calcium mass balance was on average negative (mean ± SD ?0.84 ± 1.33 mmol, range ?5.42:2.75). Predialysis ionized plasma water concentration and total ultrafiltrate were the most important predictors of calcium mass balance. A significant mobilization of calcium from the extracellular pool to a nonmodeled pool was calculated in a group of patients. Discussion: The proposed single pool variable‐volume Calcium kinetic model is adequate for prediction and quantification of intradialysis calcium mass balance, it can evaluate the eventual calcium transfer outside the extracellular pool in clinical practice.     

Non-lithographic SERS substrates: tailoring surface chemistry for Au nanoparticle cluster assembly

Near‐field plasmonic coupling and local field enhancement in metal nanoarchitectures, such as arrangements of nanoparticle clusters, have application in many technologies from medical diagnostics, solar cells, to sensors. Although nanoparticle‐based cluster assemblies have exhibited signal enhancements in surface‐enhanced Raman scattering (SERS) sensors, it is challenging to achieve high reproducibility in SERS response using low‐cost fabrication methods. Here an innovative method is developed for fabricating self‐organized clusters of metal nanoparticles on diblock copolymer thin films as SERS‐active structures. Monodisperse, colloidal gold nanoparticles are attached via a crosslinking reaction on self‐organized chemically functionalized poly(methyl methacrylate) domains on polystyrene‐block‐poly(methyl methacrylate) templates. Thereby nanoparticle clusters with sub‐10‐nanometer interparticle spacing are achieved. Varying the molar concentration of functional chemical groups and crosslinking agent during the assembly process is found to affect the agglomeration of Au nanoparticles into clusters. Samples with a high surface coverage of nanoparticle cluster assemblies yield relative enhancement factors on the order of 10⁹ while simultaneously producing uniform signal enhancements in point‐to‐point measurements across each sample. High enhancement factors are associated with the narrow gap between nanoparticles assembled in clusters in full‐wave electromagnetic simulations. Reusability for small‐molecule detection is also demonstrated. Thus it is shown that the combination of high signal enhancement and reproducibility is achievable using a completely non‐lithographic fabrication process, thereby producing SERS substrates having high performance at low cost.     

Synthesis and characterization of conjugated polymers for the obtainment of conductive patterns through laser tracing

This article describes the preparation of thin films of conjugated polymers which can enhance their specific electrical conductivity by several orders of magnitude by changing their state from insulating to conducting materials. The examined polymers, i.e., a polyacetylenic and a polythiophenic derivative, are functionalized with thioalkylic side chains and are soluble in common organic solvents from which they lead to thick homogeneous films. The films can be deposited on different substrates, either rigid or flexible, and can be easily exposed to laser radiation to make them conductive. The process is irreversible, and the final conductivity is stable over time, even in the presence of high temperatures (up to 180 °C), moisture, and air. The high stability of treated samples, easy polymer synthesis and quick and inexpensive suitably tailored laser tracing procedure make these materials very promising for applications in organic electronics and in the development of new electronic circuitry.     

Tensile stress relaxation in unsaturated granular materials

The mechanics of granular media at low liquid saturation levels remain poorly understood. Macroscopic mechanical properties are affected by microscale forces and processes, such as capillary forces, inter-particle friction, liquid flows, and particle movements. An improved understanding of these microscale mechanisms is important for a range of industrial applications and natural phenomena (e.g. landslides). This study focuses on the transient evolution of the tensile stress of unsaturated granular media under extension. Experimental results suggest that the stress state of the material evolves even after cessation of sample extension. Moreover, we observe that the packing density strongly affects the efficiency of different processes that result in tensile stress relaxation. By comparing the observed relaxation time scales with published data, we conclude that tensile stress relaxation is governed by particle rearrangement and fluid redistribution. An increased packing density inhibits particle rearrangement and only leaves fluid redistribution as the major process that governs tensile stress relaxation.     

Effect of hemodiafiltration with endogenous reinfusion on overt idiopathic chronic inflammation in maintenance hemodialysis patients: A multicenter longitudinal study

Chronic inflammation is widely diffuse in maintenance hemodialysis (MHD) patients and is associated with poor survival. Hemodiafiltration with endogenous reinfusion (HFR) is a dialysis technique, highly biocompatible, able to adsorb proinflammatory cytokines and to decrease amino acids and antioxidants loss. These features could be helpful in MHD patients affected by idiopathic chronic inflammation, but this issue remains to be elucidated. We performed a multicenter longitudinal study to assess the effect of the switching from bicarbonate HD to HFR in patients with serum C‐reactive Protein (CRP) > 5 mg/L coupled with albumin <4.0 g/dL in the last 6 months. We enrolled 24/176 (14%) patients, of which 20 patients were assessed at 4 months and 18 completed the study. We excluded 11 patients with evident causes of inflammation. At baseline, serum levels of CRP (18.7[7.0–39.4] mg/L) and albumin (3.5[3.3–3.7] g/dL) were significantly correlated (r = ?0.49; P = 0.028). The effect on CRP and albumin was almost evident in the first 4 months and remained stable until to eighth month. A strict correlation (R = ?0.49; 0.040) between percentage change of CRP (?35%) and albumin (+14%) after 8 months of HFR. These effects were associated with the reduction of IL‐6, IL‐1β, and TNF‐α and the increment of pre‐albumin and leptin, whereas the serum levels of Branched Chain Amino Acid (BCAA) remained unchanged. In MHD patients affected by idiopathic chronic inflammation the switching from BHD to HFR is associated with improvement of inflammation. Whether these favorable effects may modify the outcomes of these high‐risk patients needs to be confirmed by studies ad hoc.     

Lonidamine solid dispersions: in vitro and in vivo evaluation

Solid dispersions of lonidamine in PEG 4000 and PVP K 29/32 were prepared by the spray-drying method. Then, the binary systems were studied and characterized using differential scanning calorimetry, hot stage microscopy, and x-ray diffractometry. In vitro dissolution studies of the solid dispersed powders were performed to verify if any lonidamine dissolution rate or water solubility improvement occurred. In vivo tests were carried out on the solid dispersions and on the cyclodextrin inclusion complexes to verify if this lonidamine water solubility increase was really able to improve the in vivo drug plasma levels. Drug water solubility was increased by the solid dispersion formation, and the extent of increase depended on the polymer content of the powder. The greater increase of solubility corresponded to the highest content of polymer. Both the solid dispersions and the cyclodextrin complexes were able to improve the in vivo bioavailability of the lonidamine when administered per os. Particularly, the AUC of the drug plasma levels was increased from 1.5 to 1.9-fold depending on the type of carrier.