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91.
Janam K. Pandya Maryssa DeBonee Maria G. Corradini Mary Ellen Camire David Julian McClements Amanda J. Kinchla 《International Journal of Food Science & Technology》2019,54(12):3196-3204
Tocotrienols are members of the vitamin E family that provide many nutritional benefits. Developing tocotrienol-fortified functional foods introduces vitamin E into consumers diets without changing their food habits. The purpose of this study was to compare the stability of tocotrienols in bulk form and six food matrices at a fixed dose (40 mg kg−1) under accelerated and conventional storage conditions. The delta- and gamma-tocotrienol content was measured using HPLC, and the sensory attributes were evaluated using triangle and hedonic tests. Tocotrienol in bulk powder was less stable under stressed conditions than in bulk oil, with the powders having approximately 40% and 80% reduction in δ- and γ- after storage and bulk oil with no significant degradation. HPLC analysis demonstrated that tocotrienol content remained unchanged in dry mix lemonade, yogurt, raw and UHT milk, and margarine over time; however, complete degradation of γ- and partial degradation (up to 50%) of δ-tocotrienol was observed in bread during ambient and stressed storage conditions. A significant decrease in the δ-tocotrienol relative concentration was also observed in HTST processed milk samples. Tocotrienol addition was not perceived, and no significant difference in the product attributes and overall liking was reported in the discrimination sensory testing. 相似文献
92.
María de la Mata Sergio Cataln‐Gmez Flavio Nucciarelli Jos L. Pau Sergio I. Molina 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(43)
Plasmonics has emerged as an attractive field driving the development of optical systems in order to control and exploit light–matter interactions. The increasing interest around plasmonic systems is pushing the research of alternative plasmonic materials, spreading the operability range from IR to UV. Within this context, gallium appears as an ideal candidate, potentially active within a broad spectral range (UV–VIS–IR), whose optical properties are scarcely reported. Importantly, the smart design of active plasmonic materials requires their characterization at high spatial and spectral resolution to access the optical fingerprint of individual nanostructures, attainable by transmission electron microscopy techniques (i.e., by means of electron energy‐loss spectroscopy, EELS). Therefore, the optical response of individual Ga nanoparticles (NPs) by means of EELS measurements is analyzed, in order to spread the understanding of the plasmonic response of Ga NPs. The results show that single Ga NPs may support several plasmon modes, whose nature is extensively discussed. 相似文献
93.
Flavio Massimiliano Cecchini Martin Riedl Elisabetta Fersini Chris Biemann 《Language Resources and Evaluation》2018,52(3):733-770
This article presents a comparison of different Word Sense Induction (wsi) clustering algorithms on two novel pseudoword data sets of semantic-similarity and co-occurrence-based word graphs, with a special focus on the detection of homonymic polysemy. We follow the original definition of a pseudoword as the combination of two monosemous terms and their contexts to simulate a polysemous word. The evaluation is performed comparing the algorithm’s output on a pseudoword’s ego word graph (i.e., a graph that represents the pseudoword’s context in the corpus) with the known subdivision given by the components corresponding to the monosemous source words forming the pseudoword. The main contribution of this article is to present a self-sufficient pseudoword-based evaluation framework for wsi graph-based clustering algorithms, thereby defining a new evaluation measure (top2) and a secondary clustering process (hyperclustering). To our knowledge, we are the first to conduct and discuss a large-scale systematic pseudoword evaluation targeting the induction of coarse-grained homonymous word senses across a large number of graph clustering algorithms. 相似文献
94.
Bernaschi Massimo Celestini Alessandro Cianfriglia Marco Guarino Stefano Lombardi Flavio Mastrostefano Enrico 《World Wide Web》2022,25(3):1287-1313
World Wide Web - Tor is an open source software that allows accessing various kinds of resources, known as hidden services, while guaranteeing sender and receiver anonymity. Tor relies on a free,... 相似文献
95.
Fatemah M. Alhassawi Maria G. Corradini Michael A. Rogers 《Critical reviews in food science and nutrition》2018,58(11):1902-1916
Fluorescent molecular rotors (MRs) are compounds whose emission is modulated by segmental mobility; photoexcitation generates a locally excited (LE), planar state that can relax either by radiative decay (emission of a photon) or by formation of a twisted intramolecular charge transfer (TICT) state that can relax nonradiatively due to internal rotation. If the local environment around the probe allows for rapid internal rotation in the excited state, fast non-radiative decay can either effectively quench the fluorescence or generate a second, red-shifted emission band. Conversely, any environmental restriction to twisting in the excited state due to free volume, crowding or viscosity, slows rotational relaxation and promotes fluorescence emission from the LE state. The environmental sensitivity of MRs has been exploited extensively in biological applications to sense microviscosity in biofluids, the stability and physical state of biomembranes, and conformational changes in macromolecules. The application of MRs in food research, however, has been only marginally explored. In this review, we summarize the main characteristics of fluorescent MRs, their current applications in biological research and their current and potential applications as sensors of physical properties in food science and engineering. 相似文献
96.
Manuela Minguzzi Veronica Panichi Stefania DAdamo Silvia Cetrullo Luca Cattini Flavio Flamigni Erminia Mariani Rosa Maria Borzì 《International journal of molecular sciences》2021,22(21)
Notch signaling has been identified as a critical regulator of cartilage development and homeostasis. Its pivotal role was established by both several joint specific Notch signaling loss of function mouse models and transient or sustained overexpression. NOTCH1 is the most abundantly expressed NOTCH receptors in normal cartilage and its expression increases in osteoarthritis (OA), when chondrocytes exit from their healthy “maturation arrested state” and resume their natural route of proliferation, hypertrophy, and terminal differentiation. The latter are hallmarks of OA that are easily evaluated in vitro in 2-D or 3-D culture models. The aim of our study was to investigate the effect of NOTCH1 knockdown on proliferation (cell count and Picogreen mediated DNA quantification), cell cycle (flow cytometry), hypertrophy (gene and protein expression of key markers such as RUNX2 and MMP-13), and terminal differentiation (viability measured in 3-D cultures by luminescence assay) of human OA chondrocytes. NOTCH1 silencing of OA chondrocytes yielded a healthier phenotype in both 2-D (reduced proliferation) and 3-D with evidence of decreased hypertrophy (reduced expression of RUNX2 and MMP-13) and terminal differentiation (increased viability). This demonstrates that NOTCH1 is a convenient therapeutic target to attenuate OA progression. 相似文献
97.
Sarah Meister Laura Hahn Susanne Beyer Corinna Paul Sophie Mitter Christina Kuhn Viktoria von Schnfeldt Stefanie Corradini Kritika Sudan Christian Schulz Theresa Maria Kolben Sven Mahner Udo Jeschke Thomas Kolben 《International journal of molecular sciences》2021,22(22)
The aim of this study was to analyze the expression of peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RxRα), a binding heterodimer playing a pivotal role in the successful trophoblast invasion, in the placental tissue of preeclamptic patients. Furthermore, we aimed to characterize a possible interaction between PPARγ and H3K4me3 (trimethylated lysine 4 of the histone H3), respectively H3K9ac (acetylated lysine 9 of the histone H3), to illuminate the role of histone modifications in a defective trophoblast invasion in preeclampsia (PE). Therefore, the expression of PPARγ and RxRα was analyzed in 26 PE and 25 control placentas by immunohistochemical peroxidase staining, as well as the co-expression with H3K4me3 and H3K9ac by double immunofluorescence staining. Further, the effect of a specific PPARγ-agonist (Ciglitazone) and PPARγ-antagonist (T0070907) on the histone modifications H3K9ac and H3K4me3 was analyzed in vitro. In PE placentas, we found a reduced expression of PPARγ and RxRα and a reduced co-expression with H3K4me3 and H3K9ac in the extravillous trophoblast (EVT). Furthermore, with the PPARγ-antagonist treated human villous trophoblast (HVT) cells and primary isolated EVT cells showed higher levels of the histone modification proteins whereas treatment with the PPARγ-agonist reduced respective histone modifications. Our results show that the stimulation of PPARγ-activity leads to a reduction of H3K4me3 and H3K9ac in trophoblast cells, but paradoxically decreases the nuclear PPARγ expression. As the importance of PPARγ, being involved in a successful trophoblast invasion has already been investigated, our results reveal a pathophysiologic connection between PPARγ and the epigenetic modulation via H3K4me3 and H3K9ac in PE. 相似文献
98.
99.
Couvreur P Stella B Reddy LH Hillaireau H Dubernet C Desmaële D Lepêtre-Mouelhi S Rocco F Dereuddre-Bosquet N Clayette P Rosilio V Marsaud V Renoir JM Cattel L 《Nano letters》2006,6(11):2544-2548
Nucleoside analogues display significant anticancer or antiviral activity by interfering with DNA synthesis. However, there are some serious restrictions to their use, including their rapid metabolism and the induction of resistance. We have discovered that the linkage of nucleoside analogues to squalene leads to amphiphilic molecules that self-organize in water as nanoassemblies of 100-300 nm, irrespective of the nucleoside analogue used. The squalenoyl gemcitabine exhibited superior anticancer activity in vitro in human cancer cells and gemcitabine-resistant murine leukemia cells, and in vivo in experimental leukemia both after intravenous and oral administration. The squalenoylation of other antiretroviral nucleosides also led to more potent drugs when tested in primary cultures of HIV-infected lymphocytes. Thus, the squalenoylation is an original technology platform for generating more potent anticancer and antiviral nanomedicines. 相似文献
100.
Mohammad Masoumi Cleiton Carvalho Silva Igor Anjos Lemos Luis Flavio Gaspar Herculano Hamilton Ferreira Gomes de Abreu 《Journal of Materials Engineering and Performance》2017,26(4):1531-1539
The microstructural and textural evolution was analyzed during rolling at room temperature to obtain detailed information about the failure behavior in HSLA grade-420 steel. Electron backscatter diffraction measurements were carried out in both non-cracked and cracked areas after cold rolling to find a correlation between microstructural parameters (i.e., grain orientation, grain boundary characteristics and Taylor factor) and crack propagation. The results showed that the crack tended to propagate along grains oriented with {001} planes parallel to the normal direction with high Taylor factor value. The special boundaries associated with the {111}, {110} and {221} planes were indicated as crack resistance, while ∑ 5, 13a and 17a, which related to the {001} planes, were crack-susceptible. Transgranular cracking was subjected within grains with high Taylor factor, while mismatch in Taylor factor between neighboring grains could provide an easy path for intergranular crack propagation. 相似文献