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71.
Optimising flow processes in wastewater treatment plants requires that designers and operators take into account the flow properties of the sludge. Moreover, due to increasingly more stringent conditions on final disposal avenues such as landfill, composting, incineration etc., practitioners need to produce safer sludge in smaller quantities. Anaerobic digestion is a key treatment process for solids treatment and pathogen reduction. Due to the inherent opacity of sludge, it is impossible to visualise the mixing and flow patterns inside an anaerobic digester. Therefore, choosing an appropriate transparent model fluid which can mimic the rheological behaviour of sludge is imperative for visualisation of the hydrodynamic functioning of an anaerobic digester.Digested sludge is a complex material with time dependent non-Newtonian thixotropic characteristics. In steady state, it can be modelled by a basic power-law. However, for short-time processes the Herschel-Bulkley model can be used to model liquid-like properties.The objective of this study was to identify transparent model fluids which will mimic the behaviour of real sludge. A comparison of three model fluids, Carboxymethyl Cellulose (CMC), Carbopol gel and Laponite clay revealed that these fluids could each model certain aspects of sludge behaviour. It is concluded that the rheological behaviour of sludge can be modelled using CMC in steady state flow at high shear rates, Carbopol gel for short-time flow processes and Laponite clay suspension where time dependence is dominant. 相似文献
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The effect of varying ruthenium contents of 0.00, 0.14, 0.22, and 0.28% on the corrosion of 22%Cr-9%Ni-3%Mo duplex stainless steel (DSS) after different immersion intervals in 3.5% NaCl solutions has been investigated. The study was carried out using open-circuit potential, potentiodynamic cyclic polarization, chronoamperometry, electrochemical impedance spectroscopy, and weight-loss measurements. Particular attention was paid to the effect of Ru on the pitting corrosion of DSS in the chloride solutions. Electrochemical measurements indicated that the presence of Ru passivates the DSS alloy by decreasing its corrosion parameters. Furthermore, it shifts the corrosion and pitting potentials to more positive values. This effect was found to increase with increasing Ru content and also with increased immersion time of the alloy in the chloride solution before measurements. Weight-loss time data after varied exposure periods (4-20 days) showed that the weight-loss and corrosion rate of DSS significantly decrease with increasing Ru contents. 相似文献
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76.
F. C. Levey M. B. Cortie L. A. Cornish 《Metallurgical and Materials Transactions A》2000,31(8):1917-1923
A gold alloy with 18 wt pct Cu and 6 wt pct Al undergoes a reversible displacive phase transformation between an incompletely
ordered L21 parent phase and a tetragonal product. The characteristics of these transformations were studied using acoustic emission,
dilatometry, X-ray diffraction, and metallography. The morphology of the transformation products, the structure of the parent
phase, and the generation of significant acoustic emission during the transformations indicate that they are at least quasi-martensitic,
if not martensitic, and that this system is an example of a β-phase shape-memory alloy (SMA). The onset temperatures of the transformations depend on the prior thermal history of the
sample. The martensite start (M
s
) temperature is between 30 °C and 20 °C. The system exhibits hysteresis and will revert to the parent phase when reheated,
with an austenite start (A
s
) temperature between 55 °C and 80 °C. However, freshly cast or solution-annealed and quenched samples of the alloy do not
transform to the tetragonal phase. Aging of such material at temperatures between 30 °C and 200 °C is required before they
will manifest the displacive transformation. The “martensite” phase is considerably more resistant to aging-induced stabilization
than that of most other SMAs. 相似文献
77.
Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A—Treated Stem Cells
Flora Cozzolino Ilaria Iacobucci Vittoria Monaco Tiziana Angrisano Maria Monti 《International journal of molecular sciences》2021,22(4)
Trichostatin A ([R-(E,E)]-7-[4-(dimethylamino) phenyl]-N-hydroxy- 4,6-dimethyl- 7-oxo-2,4-heptadienamide, TSA) affects chromatin state through its potent histone deacetylase inhibitory activity. Interfering with the removal of acetyl groups from lysine residues in histones is one of many epigenetic regulatory processes that control gene expression. Histone deacetylase inhibition drives cells toward the differentiation stage, favoring the activation of specific genes. In this paper, we investigated the effects of TSA on H3 and H4 lysine acetylome and methylome profiling in mice embryonic stem cells (ES14), treated with trichostatin A (TSA) by using a new, untargeted approach, consisting of trypsin-limited proteolysis experiments coupled with MALDI-MS and LC-MS/MS analyses. The method was firstly set up on standard chicken core histones to probe the optimized conditions in terms of enzyme:substrate (E:S) ratio and time of proteolysis and, then, applied to investigate the global variations of the acetylation and methylation state of lysine residues of H3 and H4 histone in the embryonic stem cells (ES14) stimulated by TSA and addressed to differentiation. The proposed strategy was found in its simplicity to be extremely effective in achieving the identification and relative quantification of some of the most significant epigenetic modifications, such as acetylation and lysine methylation. Therefore, we believe that it can be used with equal success in wider studies concerning the characterization of all epigenetic modifications. 相似文献
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79.
HR Rosen S Chou CL Corless DR Gretch KD Flora A Boudousquie SL Orloff JM Rabkin KG Benner 《Canadian Metallurgical Quarterly》1997,64(5):721-726
BACKGROUND: Despite recent advances in diagnosis and treatment, cytomegalovirus (CMV) infection continues to be a common cause of morbidity in liver transplant (LT) recipients. Because CMV infection suppresses cell-mediated immunity, which seems to be important in neutralizing hepatitis C virus (HCV) infection, we assessed the impact of CMV infection on histopathological HCV recurrence after LT. METHODS: The study group was comprised of 43 consecutive LT recipients with at least 6 months of histologic follow-up. Group 1 consisted of the 8 patients who developed CMV viremia after LT; group 2 comprised the 35 patients without CMV viremia. There was no significant difference with regard to age, initial immunosuppression, incidence of rejection, distribution of HCV genotypes, or mean follow-up between the groups. Semiquantitative histopathologic assessment of allograft hepatitis was performed using the Knodell's score. RESULTS: The mean total Knodell score of the final allograft biopsy was significantly greater in group 1 patients (P=0.016), with most of the difference due to periportal/bridging necrosis (P=0.009) and lobular activity subitem (P=0.01) scores. Half of the CMV viremic patients eventually developed allograft cirrhosis as compared with 11% of the CMV-negative patients (P=0.027). Accordingly, the cirrhosis-free actuarial survival by Kaplan-Meier estimates was significantly diminished in the CMV viremic patients. Glycoprotein B genotype analysis of CMV isolates revealed no significant differences between patients who did and those who did not develop allograft cirrhosis. CONCLUSIONS: After LT for chronic HCV, patients who develop CMV viremia incur a significantly greater risk of severe HCV recurrence. 相似文献
80.
EA Musgrove A Swarbrick CS Lee AL Cornish RL Sutherland 《Canadian Metallurgical Quarterly》1998,18(4):1812-1825
The steroid hormone progesterone regulates proliferation and differentiation in the mammary gland and uterus by cell cycle phase-specific actions. In breast cancer cells the predominant effect of synthetic progestins is long-term growth inhibition and arrest in G1 phase. Progestin-mediated growth arrest of T-47D breast cancer cells was preceded by inhibition of cyclin D1-Cdk4, cyclin D3-Cdk4, and cyclin E-Cdk2 kinase activities in vitro and reduced phosphorylation of pRB and p107. This was accompanied by decreases in the expression of cyclins D1, D3, and E, decreased abundance of cyclin D1- and cyclin D3-Cdk4 complexes, increased association of the cyclin-dependent kinase (CDK) inhibitor p27 with the remaining Cdk4 complexes, and changes in the molecular masses and compositions of cyclin E complexes. In control cells cyclin E eluted from Superdex 200 as two peaks of approximately 120 and approximately 200 kDa, with the 120-kDa peak displaying greater cyclin E-associated kinase activity. Following progestin treatment, almost all of the cyclin E was in the 200-kDa, low-activity form, which was associated with the CDK inhibitors p21 and p27; this change preceded the inhibition of cell cycle progression. These data suggest preferential formation of this higher-molecular-weight, CDK inhibitor-bound form and a reduced number of cyclin E-Cdk2 complexes as mechanisms for the decreased cyclin E-associated kinase activity following progestin treatment. Ectopic expression of cyclin D1 in progestin-inhibited cells led to the reappearance of the 120-kDa active form of cyclin E-Cdk2 preceding the resumption of cell cycle progression. Thus, decreased cyclin expression and consequent increased CDK inhibitor association are likely to mediate the decreases in CDK activity accompanying progestin-mediated growth inhibition. 相似文献