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21.
Amélie Berton Stéphanie Rouvellac Benoit Robert Florence Rousseau Christelle Lopez Isabelle Crenon 《Food Hydrocolloids》2012
Although the bioavailability of dietary lipids is of primary importance in human nutrition and health, the mechanisms involved in lipid digestion are not fully understood and are of growing interest. The objective of this study was to determine the effect of the size of milk fat globules and of the composition of their interface on the activity of the human pancreatic lipase (PL). Native milk fat globules of various sizes covered by their biological membrane (MFGM) and homogenized fat globules of various sizes covered by milk proteins were prepared from whole milk and underwent lipolysis by the human PL with colipase and bile salts. A lag phase preceding the hydrolysis of milk TAG occurred with all native milk fat globules samples but not with homogenized milk samples. The kinetic parameters of human PL were determined by measuring the enzyme activity either after the lag phase for native milk fat globules samples or immediately after the addition of the enzyme for homogenized milk samples. The catalytic efficiency of human PL is 4.6-fold higher on small (1.8 μm) than large (6.7 μm) native milk fat globules, related to a 3.6-fold larger available surface. Despite the 25-fold larger available surface, milk TAG from homogenized milk are only 2-fold better hydrolyzed compared to native milk fat globules, as a possible result of a less favourable interface covered by milk proteins. The potential mechanisms involved in native vs. homogenized milk fat globules digestion by the human PL are discussed. Our study highlights the crucial role of the MFGM in the efficient digestion of milk fat globules and brings new insight for the design of dairy products and infant formulas. 相似文献
22.
Amir H. Tavakoli Renzo Campostrini Christel Gervais Florence Babonneau Joachim Bill Gian D. Sorarù Alexandra Navrotsky 《Journal of the American Ceramic Society》2014,97(1):303-309
The structure and properties of polymer‐derived Si–(B–)O–C glasses have been shown to be significantly influenced by the boron content and pyrolysis temperature. This work determined the impact of these two parameters on the thermodynamic stability of these glasses. High‐temperature oxide melt solution calorimetry was performed on a series of amorphous samples, with varying boron contents (0–7.7 at.%), obtained by pyrolysis of precursors made by a sol–gel technique. Thermodynamic analysis of the calorimetric results demonstrated that at a constant pyrolysis temperature, adding boron makes the materials energetically less stable. While the B‐containing glasses pyrolyzed at 1000°C were energetically less stable than the competitive crystalline components, increasing the pyrolysis temperature to 1200°C led to their enthalpic stability. 29Si and 11B MAS nuclear magnetic resonance (NMR) spectroscopy measurements on selected samples confirmed a decrease in the concentrations of mixed Si‐centered SOiC4?i and B‐centered BOjC3?j bonds at the expense of formation of SiO4 and B(OSi)3 species (indicating a tendency toward phase separation) when the boron content and pyrolysis temperature increased. In light of the findings from calorimetry and NMR spectroscopy, we propose a structure–energetic relationship in Si–(B–)O–C glasses. 相似文献
23.
Issa M. El-Nahhal Shehata M. Zourab Fawzi S. Kodeh Abdelraouf A. Elmanama Mohamed Selmane Isabelle Genois Florence Babonneau 《Journal of Materials Science: Materials in Electronics》2013,24(10):3970-3975
Zinc oxide nanoparticles were prepared and subsequently deposited onto the surface of the cotton fiber by ultrasonic irradiation. The optical, structure and morphology of the coated and un-coated cotton were examined by UV, fourier transform infrared spectroscopy, X-ray diffraction analysis (XRD) and scanning electron microscope (SEM)/Energy Dispersive X-ray analysis. XRD analysis revealed the presence of the crystalline metal oxide of hexagonal phase with an average crystallite size of 12 nm. These nanoparticles are probably physically adsorbed onto the cotton fiber surface. SEM analysis showed a distribution of ZnO nanorod assemblies of various diameters and lengths physically adsorbed onto the cotton fiber surface may take place. The ZnO-cotton fiber nano-composite were tested against Escherichia coli (gram negative) and Staphylococcus aureus (gram positive) cultures, and showed a significant antimicrobial activity. 相似文献
24.
Manhal Abouzlam Régis Ouvrard Driss Mehdi Florence Pontlevoy Bertrand Gombert Nathalie Karpel Vel Leitner Sahidou Boukari 《Control Engineering Practice》2013,21(1):105-112
This paper deals with the control of a wastewater treatment pilot by catalytic ozonation. In general, catalytic ozonation processes operate with a deliberate ozone overproduction to obtain a treated water which respects discharge standards. But, in this case, the oxygen consumption is not optimal and the operating costs are important. The objective of this study focuses on the optimization of the catalytic ozonation reactor. A continuous-time transfer function model is identified to represent the pilot behavior, and an optimal control is proposed to obtain a significant abatement of the pollutant. In this application, the pollutant abatement is represented by the absorbance. 相似文献
25.
26.
Florence T. T. Phua 《Construction Management & Economics》2013,31(3):309-320
It is obvious that the performance of firms hinges upon the dynamics of both industry‐ and firm‐specific factors. A less obvious, and perhaps a more important, line of inquiry is that to the extent that they have a bearing on firm performance, how much do these two groups of factors respectively predict firm performance? To date, performance differences among construction firms that stem from industry‐ and firm‐specific differential effect has remained largely unexplored. Using a dataset comprising 526 firms across various construction‐related sectors, the sector‐by‐sector firm performance variation that is attributable to the heterogeneity of both industry‐ and firm‐specific characteristics was empirically examined. That statistically significant results of different effect sizes are found indicates that although these factors are often assumed to be intertwined it is possible to study their respective impact on firm performance. Future studies could usefully replicate and extend this study to construction firms in other countries to further investigate what drives firm performance under different national, industry and firm contexts. 相似文献
27.
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors 下载免费PDF全文
Dr. Gordon J. Florence Andrew L. Fraser Dr. Eoin R. Gould Elizabeth F. King Stefanie K. Menzies Dr. Joanne C. Morris Marie I. Thomson Dr. Lindsay B. Tulloch Marija K. Zacharova Prof. Dr. Terry K. Smith 《ChemMedChem》2016,11(14):1503-1506
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously reported triazole analogues, in this study we describe the synthesis and biological testing of other novel heterocyclic acetogenin‐inspired derivatives, namely 3,5‐isoxazoles, furoxans, and furazans. Several of these compounds maintain low‐micromolar levels of inhibition against Trypanosoma brucei, whilst having no observable inhibitory effect on mammalian cells, leading to the possibility of novel lead compounds for selective treatment. 相似文献
28.
Jerome Kluza Victoriane Peugnet Blanche Daunou William Laine Gwenola Kervoaze Gaëlle Rmy Anne Loyens Patrice Maboudou Quentin Fovez Corinne Grangette Isabelle Wolowczuk Philippe Gosset Guillaume Garon Philippe Marchetti Florence Pinet Muriel Pichavant Emilie Dubois-Deruy 《International journal of molecular sciences》2022,23(1)
Mitochondrial dysfunctions are implicated in several pathologies, such as metabolic, cardiovascular, respiratory, and neurological diseases, as well as in cancer and aging. These metabolic alterations are usually assessed in human or murine samples by mitochondrial respiratory chain enzymatic assays, by measuring the oxygen consumption of intact mitochondria isolated from tissues, or from cells obtained after physical or enzymatic disruption of the tissues. However, these methodologies do not maintain tissue multicellular organization and cell-cell interactions, known to influence mitochondrial metabolism. Here, we develop an optimal model to measure mitochondrial oxygen consumption in heart and lung tissue samples using the XF24 Extracellular Flux Analyzer (Seahorse) and discuss the advantages and limitations of this technological approach. Our results demonstrate that tissue organization, as well as mitochondrial ultrastructure and respiratory function, are preserved in heart and lung tissues freshly processed or after overnight conservation at 4 °C. Using this method, we confirmed the repeatedly reported obesity-associated mitochondrial dysfunction in the heart and extended it to the lungs. We set up and validated a new strategy to optimally assess mitochondrial function in murine tissues. As such, this method is of great potential interest for monitoring mitochondrial function in cohort samples. 相似文献
29.
Florence Bonnet-Magnaval Leïla Halidou Diallo Valrie Brunchault Nathalie Laugero Florent Morfoisse Florian David Emilie Roussel Manon Nougue Audrey Zamora Emmanuelle Marchaud Florence Tatin Anne-Catherine Prats Barbara Garmy-Susini Luc DesGroseillers Eric Lacazette 《International journal of molecular sciences》2022,23(1)
30.
Alexandre Joushomme Andr Garenne Mlody Dufosse Rmy Renom Hermanus Johannes Ruigrok Yann Loick Chappe Anne Canovi Lorenza Patrignoni Annabelle Hurtier Florence Poulletier de Gannes Isabelle Lagroye Philippe Lvêque Noëlle Lewis Muriel Priault Delia Arnaud-Cormos Yann Percherancier 《International journal of molecular sciences》2022,23(2)
It remains controversial whether exposure to environmental radiofrequency signals (RF) impacts cell status or response to cellular stress such as apoptosis or autophagy. We used two label-free techniques, cellular impedancemetry and Digital Holographic Microscopy (DHM), to assess the overall cellular response during RF exposure alone, or during co-exposure to RF and chemical treatments known to induce either apoptosis or autophagy. Two human cell lines (SH-SY5Y and HCT116) and two cultures of primary rat cortex cells (astrocytes and co-culture of neurons and glial cells) were exposed to RF using an 1800 MHz carrier wave modulated with various environmental signals (GSM: Global System for Mobile Communications, 2G signal), UMTS (Universal Mobile Telecommunications System, 3G signal), LTE (Long-Term Evolution, 4G signal, and Wi-Fi) or unmodulated RF (continuous wave, CW). The specific absorption rates (S.A.R.) used were 1.5 and 6 W/kg during DHM experiments and ranged from 5 to 24 W/kg during the recording of cellular impedance. Cells were continuously exposed for three to five consecutive days while the temporal phenotypic signature of cells behavior was recorded at constant temperature. Statistical analysis of the results does not indicate that RF-EMF exposure impacted the global behavior of healthy, apoptotic, or autophagic cells, even at S.A.R. levels higher than the guidelines, provided that the temperature was kept constant. 相似文献