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排序方式: 共有1785条查询结果,搜索用时 25 毫秒
51.
Let There be Light: Polymeric Micelles with Upper Critical Solution Temperature as Light‐Triggered Heat Nanogenerators for Combating Drug‐Resistant Cancer 下载免费PDF全文
Yongyan Deng Florian Käfer Tingting Chen Qiao Jin Jian Ji Seema Agarwal 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(37)
Complete drug release and efficient drug retention are two critical factors in reversing drug resistance in cancer therapy. In this regard, polymeric micelles with an upper critical solution temperature (UCST) are designed as a new exploration to reverse drug resistance. The amphiphilic UCST‐type block copolymers are used to encapsulate photothermal agent IR780 and doxorubicin (DOX) simultaneously. The integrated UCST‐type drug nanocarriers show light‐triggered multiple synergistic effects to reverse drug resistance and are expected to kill three birds with one stone: First, owing to the photothermal effect of IR780, the nanocarriers will be dissociated upon exposure to laser irradiation, leading to complete drug release. Second, the photothermal effect‐induced hyperthermia is expected to avoid the efflux of DOX and realize efficient drug retention. Last but not least, photothermal ablation of cancer cells can be achieved after laser irradiation. Therefore, the UCST‐type drug nanocarriers provide a new strategy in reversing drug resistance in cancer therapy. 相似文献
52.
Florian Dotzler 《Datenschutz und Datensicherheit - DuD》2011,35(3):192-196
Editorial
Biometrie — zwischen Pragmatik und Forschung? 相似文献53.
54.
The global scale and distribution of companies have changed the economy and dynamics of businesses. Web-based collaborations and cross-organizational processes typically require dynamic and context-based interactions between people and services. However, finding the right partner to work on joint tasks or to solve emerging problems in such scenarios is challenging due to scale and temporary nature of collaborations. Furthermore, actor competencies evolve over time, thus requiring dynamic approaches for their management. Web services and SOA are the ideal technical framework to automate interactions spanning people and services. To support such complex interaction scenarios, we discuss mixed service-oriented systems that are composed of both humans and software services, interacting to perform certain activities. As an example, consider a professional online support community consisting of interactions between human participants and software-based services. We argue that trust between members is essential for successful collaborations. Unlike a security perspective, we focus on the notion of social trust in collaborative networks. We show an interpretative rule-based approach to enable humans and services to establish trust based on interactions and experiences, considering their context and subjective perceptions. 相似文献
55.
Wil M. P. van der Aalst Marlon Dumas Florian Gottschalk Arthur H. M. ter Hofstede Marcello La Rosa Jan Mendling 《Formal Aspects of Computing》2010,22(3-4):459-482
A configurable process model captures a family of related process models in a single artifact. Such models are intended to be configured to fit the requirements of specific organizations or projects, leading to individualized process models that are subsequently used for domain analysis or solution design. This article proposes a formal foundation for individualizing configurable process models incrementally, while preserving correctness, both with respect to syntax and behavioral semantics. Specifically, assuming the configurable process model is behaviorally sound, the individualized process models are guaranteed to be sound. The theory is first developed in the context of Petri nets and then extended to a process modeling notation widely used in practice, namely Event-driven Process Chains. 相似文献
56.
Ferstl F Bürger K Theisel H Westermann R 《IEEE transactions on visualization and computer graphics》2010,16(6):1569-1577
Streak surfaces are among the most important features to support 3D unsteady flow exploration, but they are also among the computationally most demanding. Furthermore, to enable a feature driven analysis of the flow, one is mainly interested in streak surfaces that show separation profiles and thus detect unstable manifolds in the flow. The computation of such separation surfaces requires to place seeding structures at the separation locations and to let the structures move correspondingly to these locations in the unsteady flow. Since only little knowledge exists about the time evolution of separating streak surfaces, at this time, an automated exploration of 3D unsteady flows using such surfaces is not feasible. Therefore, in this paper we present an interactive approach for the visual analysis of separating streak surfaces. Our method draws upon recent work on the extraction of Lagrangian coherent structures (LCS) and the real-time visualization of streak surfaces on the GPU. We propose an interactive technique for computing ridges in the finite time Lyapunov exponent (FTLE) field at each time step, and we use these ridges as seeding structures to track streak surfaces in the time-varying flow. By showing separation surfaces in combination with particle trajectories, and by letting the user interactively change seeding parameters such as particle density and position, visually guided exploration of separation profiles in 3D is provided. To the best of our knowledge, this is the first time that the reconstruction and display of semantic separable surfaces in 3D unsteady flows can be performed interactively, giving rise to new possibilities for gaining insight into complex flow phenomena. 相似文献
57.
Florian Hartig Martin Horn Martin Drechsler 《Environmental Modelling & Software》2010,25(11):1479-1480
EcoTRADE is a multi-player network game of a virtual biodiversity credit market. Each player controls the land use of a certain amount of parcels on a virtual landscape. The biodiversity credits of a particular parcel depend on neighboring parcels, which may be owned by other players. The game can be used to study the strategies of players in experiments or classroom games and as a communication tool for stakeholders participating in credit markets that include spatially interdependent credits. 相似文献
58.
59.
Making it easier for older people to talk to smart homes: the effect of early help prompts 总被引:1,自引:0,他引:1
K. Maria Wolters Klaus-Peter Engelbrecht Florian Gödde Sebastian Möller Anja Naumann Robert Schleicher 《Universal Access in the Information Society》2010,9(4):311-325
It is well known that help prompts shape how users talk to spoken dialogue systems. This study investigated the effect of
help prompt placement on older users’ interaction with a smart home interface. In the dynamic help condition, help was only
given in response to system errors; in the inherent help condition, it was also given at the start of each task. Fifteen older
and sixteen younger users interacted with a smart home system using two different scenarios. Each scenario consisted of several
tasks. The linguistic style users employed to communicate with the system (interaction style) was measured using the ratio of commands to the overall utterance length (keyword ratio) and the percentage of content
words in the user’s utterance that could be understood by the system (shared vocabulary). While the timing of help prompts
did not affect the interaction style of younger users, it was early task-specific help supported older users in adapting their
interaction style to the system’s capabilities. Well-placed help prompts can significantly increase the usability of spoken
dialogue systems for older people. 相似文献
60.
Holger Maune Mohsen Sazegar Yuliang Zheng Xianghui Zhou Andre Giere Patrick Scheele Florian Paul Joachim R. Binder Rolf Jakoby 《Microsystem Technologies》2011,17(2):213-224
The research on materials and systems for tunable microwave devices has gained attraction within the last years. The radio
frequency characterization and the component design of tunable microwave components based on dielectric ceramics especially
barium-strontium-titanate (BST) are presented in this second part, whereas the basic material properties are discussed in
detail in the first part. After a short introduction to the processing technology used for the fabrication of tunable components
based on a BST thick film, the relations between microwave properties and material properties as well as the microstructure
are presented in detail. The design process for tunable microwave components based on BST thick films is described. Especially
the considerations related to micro- and macrostructure and their connection are highlighted. The paper closes with two different
application examples: a reconfigurable array antenna for satellite communication and varactors for high power applications. 相似文献