Fluorescent Markers for Amyloid-β Detection: Computational Insights

In vivo detection of cerebral amyloid-β plaques is essential for an early diagnosis of Alzheimer′s disease. Optical imaging, which employs fluorescent markers emitting in the near-infrared range, is a growing alternative to nuclear techniques, with indisputable advantages. The rational design of amyloid markers requires optimization of both the optical and binding properties, and of their mutual interaction. In this work, the structural aspects that determine the performance of selected amyloid markers have been analyzed, focusing on the contributions offered by computational techniques.     

Mitochondria as Key Targets of Cardioprotection in Cardiac Ischemic Disease: Role of Thyroid Hormone Triiodothyronine

Ischemic heart disease is the major cause of mortality and morbidity worldwide. Early reperfusion after acute myocardial ischemia has reduced short-term mortality, but it is also responsible for additional myocardial damage, which in the long run favors adverse cardiac remodeling and heart failure evolution. A growing body of experimental and clinical evidence show that the mitochondrion is an essential end effector of ischemia/reperfusion injury and a major trigger of cell death in the acute ischemic phase (up to 48–72 h after the insult), the subacute phase (from 72 h to 7–10 days) and chronic stage (from 10–14 days to one month after the insult). As such, in recent years scientific efforts have focused on mitochondria as a target for cardioprotective strategies in ischemic heart disease and cardiomyopathy. The present review discusses recent advances in this field, with special emphasis on the emerging role of the biologically active thyroid hormone triiodothyronine (T3).     

Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging

Numerous specific age-related morbidities have been correlated with low intake and serum levels of tocopherols and tocotrienols. We performed a review in order to evaluate the extant evidence regarding: (1) the association between intake and serum levels of tocopherols and tocotrienols and age-related pathologies (osteoporosis, sarcopenia and cognitive impairment); and (2) the optimum diet therapy or supplementation with tocopherols and tocotrienols for the treatment of these abnormalities. This review included 51 eligible studies. The recent literature underlines that, given the detrimental effect of low intake and serum levels of tocopherols and tocotrienols on bone, muscle mass, and cognitive function, a change in the lifestyle must be the cornerstone in the prevention of these specific age-related pathologies related to vitamin E-deficient status. The optimum diet therapy in the elderly for avoiding vitamin E deficiency and its negative correlates, such as high inflammation and oxidation, must aim at achieving specific nutritional goals. These goals must be reached through: accession of the elderly subjects to specific personalized dietary programs aimed at achieving and/or maintaining body weight (avoid malnutrition); increase their intake of food rich in vitamin E, such as derivatives of oily seeds (in particular wheat germ oil), olive oil, hazelnuts, walnuts, almonds, and cereals rich in vitamin E (such as specific rice cultivar rich in tocotrienols) or take vitamin E supplements. In this case, vitamin E can be correctly used in a personalized way either for the outcome from the pathology or to achieve healthy aging and longevity without any adverse effects.     

Characterization of boron doped diamond during oxidation processes: Relationship between electronic structure and electrochemical activity

This work investigates the behaviour of BDD samples differently aged by an oxidative treatment. Two series of data are presented: the first in acid solutions was used to derive information about the electronic structure of the samples, whereas measurements in equimolar ferro/ferri cyanide solutions were performed to test the activity of the samples towards charge transfer reaction. Flat band potential as well as energy levels of conduction and valence bands were calculated for new and aged samples. These parameters, together with the current voltage response, are crucial information for a comprehensive interpretation of the behaviour of samples.     

Molecular beam deposition of LaAlO3 on silicon for sub-22 nm CMOS technological nodes: Towards a perfect control of the oxide/silicon heterointerface

This work reports on the development of thin amorphous LaAlO₃ (LAO) layers on Si(0 0 1) for their integration as gate oxide in sub-22 nm CMOS technologies. The crucial influence of the Si surface preparation is highlighted and an optimized surface preparation procedure is proposed. An unexpected interface reaction during Rapid Thermal Annealing is also evidenced, and an explanation attempt of the origin of this reaction, involving surface contaminants, is proposed.     

An environmental impact assessment of exported wood pellets from Canada to Europe

There have been increased interests on exporting wood pellets from Canada to Europe to meet the increased demand on biofuels in European countries. The wood pellet industry in Canada, especially in the west coastal region, has grown at an annual rate of more than 20% averaged over last 5 years due to the steady supply of wood residues. This paper attempted to analyze the fuel consumption and air emissions associated with the wood pellet production in British Columbia and export to Sweden based on a streamlined life cycle analysis, starting from tree harvesting for wood residue production to the shipping of wood pellets from Vancouver to Stockholm in Sweden. The results showed that about 7.2 GJ of energy is consumed for each tonne of wood pellets produced and shipped to Europe, representing about 39% of the total energy content of the wood pellets. Among those energies consumed over the life cycle, about 2.6 GJ is associated with long-distance ocean transportation. The ocean transportation is also the major contributor to environmental and health impacts, followed by the pellet production processes. The fossil fuel content, which quantifies the amount of fossil fuel consumed over the life cycle, for exported wood pellets ranged from 19% to 35%, depending on whether natural gas or wood residue is used in the drying operation during the wood pellet production stage. To reduce the fossil fuel content and the environmental impacts, wood residues should be used in the drying operation and, if possible, local market should be explored to reduce the energy consumption associated with wood pellet transportation over long distances.     

Quantum Correlations in a Generalized Spin Star System

The problem of detecting quantum signatures in the correlations formed in dynamical evolution of quantum bipartite systems receives a lot of attention in current literature. Generally speaking, the occurrence of correlations between two observables of a system does not necessarily reflect nonclassical behaviour. In this paper, the exact dynamics of a pair of uncoupled spins 1/2 interacting with a common spin 1/2 bath is investigated. Starting from a separable initial condition, the ability of the system to develop purely quantum correlations is brought to light. Physical interpretation of the concurrence function as well as a suggestion on how to measure it are given.