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排序方式: 共有9432条查询结果,搜索用时 31 毫秒
941.
Dragos Horvath Michael Lisurek Bernd Rupp Ronald Kühne Edgar Specker Jens von Kries Didier Rognan C. David Andersson Fredrik Almqvist Mikael Elofsson Per‐Anders Enqvist Anna‐Lena Gustavsson Nikita Remez Jordi Mestres Gilles Marcou Alexander Varnek Marcel Hibert Jordi Quintana Ronald Frank 《ChemMedChem》2014,9(10):2309-2326
This work describes a collaborative effort to define and apply a protocol for the rational selection of a general‐purpose screening library, to be used by the screening platforms affiliated with the EU‐OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening‐compliant physicochemical properties, loose compliance to drug‐likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre‐filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in‐house methodology and expertise. An in‐depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics‐driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general‐purpose self‐organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU‐OPENSCREEN library could be directly compared with distributions of known bioactives of various classes. This mapping highlights the relevance of the selection and shows how the consensus reached by merging the five different 40K selections contributes to achieve this relevance. The approach also allows one to readily identify subsets of target‐ or target‐class‐oriented compounds from the EU‐OPENSCREEN library to suit the needs of the diverse range of potential users. The final EU‐OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe‐wide collaborative effort toward the common objective of building best‐in‐class European open screening platforms. 相似文献
942.
Markus Tauber Christian Wagner Frank Pallas 《e & i Elektrotechnik und Informationstechnik》2014,131(1):33-36
The prevalence of machine-to-machine (M2M) will continue to increase because of the connection and interlinking of services in the domain of critical infrastructures (e.g. “smart grids”, traffic management or surveillance systems). This is leading to a constant rise of required computational and storage resources. As field systems typically offer only limited computing and storage capabilities and as many applications require a global view to integrated data from various devices, a natural location to store data and perform analysis tasks is in the Cloud, where an abundance of flexible resources can be used. However, this results in a number of security and privacy challenges in combination with some legal and technical considerations that need to be addressed. In this paper, we will investigate and categorize the above challenges associated with using the Cloud in a critical infrastructure and M2M context. 相似文献
943.
Biomedical Applications: Endocytic pH‐Triggered Degradation of Nanoengineered Multilayer Capsules (Adv. Mater. 12/2014)
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948.
Andreas Mauerer Bastian Lange Goetz Hannes Welsch Frank Heidenau Werner Adler Raimund Forst Richard Heiner Richter 《Journal of materials science. Materials in medicine》2014,25(3):813-821
The aim of this study was the investigation of a copper-filled TiO2 coating, that in vitro showed good antibacterial properties combined with good tissue tolerance in an animal model. To better understand the antibacterial mechanism of the bioactive coating the release of copper (Cu) ions over time was monitored to be able to detect possible threats as well as possible fields of application. 30 New Zealand White rabbits were divided into two groups with 15 animals per group. In group 1 (control group) Ti6Al4 V bolts were implanted into the distal femur, in group 2 the Ti6Al4 V bolts were coated with four TiO2-coatings with integrated Cu2+-ions (4 × Cu–TiO2). Blood tests were performed weekly until the animals were sacrificed 4 weeks postoperative. The maximum peak of Cu and ceruloplasmin concentration could be seen in both groups one week postoperative, whereas the Cu values in group II were significantly higher. The Cu concentration in both groups approximated the initial basic values 4 weeks postoperative. The 4 × Cu–TiO2 coating tested in our rabbit model for total knee arthroplasty is an active coating that releases potentially antibacterial Cu2+ for 4 weeks with a peak 1 week postoperative. The bioactive coating could be a promising approach for a use in the field of implant related infection, orthopaedic revision and tumor surgery in the future. 相似文献
949.
Hongyu Chen Bin Qi Thomas Moore Daniel C. Colvin Thomas Crawford John C. Gore Frank Alexis O. Thompson Mefford Jeffrey N. Anker 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(1):160-168
A method is developed to fabricate monodispersed biocompatible Yb/Er or Yb/Tm doped β‐NaGdF4 upconversion phosphors using polyelectrolytes to prevent irreversible particle aggregation during conversion of the precursor, Gd2O(CO3)2?H2O:Yb/Er or Yb/Tm, to β‐NaGdF4:Yb/Er or Yb/Tm. The polyelectrolyte on the outer surface of nanophosphors also provided an amine tag for PEGylation. This method is also employed to fabricate PEGylated magnetic upconversion phosphors with Fe3O4 as the core and β‐NaGdF4 as a shell. These magnetic upconversion nanophosphors have relatively high saturation magnetization (7.0 emu g?1) and magnetic susceptibility (1.7 × 10?2 emu g?1 Oe?1), providing them with large magnetophoretic mobilities. The magnetic properties for separation and controlled release in flow, their optical properties for cell labeling, deep tissue imaging, and their T1‐ and T2‐weighted magnetic resonance imaging (MRI) relaxivities are studied. The magnetic upconversion phosphors display both strong magnetophoresis, dual MRI imaging (r1 = 2.9 mM?1 s?1, r2 = 204 mM?1 s?1), and bright luminescence under 1 cm chicken breast tissue. 相似文献
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