Optisch aktive Amine durch Lipase-katalysierte Methoxyacetylierung

Optically Active Amines via Lipase-Catalyzed Methoxyacetylation Racemic amines can be efficiently resolved using ethylmethoxyacetate as acylating agent in a lipase-catalyzed reaction. The reaction of 1-phenyethylamine with ethylmethoxyacetate in the presence of a lipase from Burkholderia plantarii is presented. Excellent yields and selectivity and minimal amount of enzyme characterize this new process.     

The job demands-resources model of burnout.

The job demands-resources (JD-R) model proposes that working conditions can be categorized into 2 broad categories, job demands and job resources, that are differentially related to specific outcomes. A series of LISREL analyses using self-reports as well as observer ratings of the working conditions provided strong evidence for the JD-R model: Job demands are primarily related to the exhaustion component of burnout, whereas (lack of) job resources are primarily related to disengagement. Highly similar patterns were observed in each of 3 occupational groups: human services, industry, and transport (total N?=?374). In addition, results confirmed the 2-factor structure (exhaustion and disengagement) of a new burnout instrument—the Oldenburg Burnout Inventory—and suggested that this structure is essentially invariant across occupational groups. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Zur Torsionsbemessung von Stahlbeton‐ und Spannbetonbalken nach DIN 1045‐1

Torsion Design of reinforced and prestressed concrete Beams according to DIN 1045‐1 The DIN 1045‐1 provisions specify two different methods for torsion design regarding the concrete strut angle. The analysis of a database containing about 300 tests on reinforced and prestressed concrete beams under pure torsion or combined loading shows that under certain loading conditions the methods should not be used alternatively. In addition, the database also shows that the strength of the concrete strut according to DIN 1045‐1 overestimates the torsional capacity in general. On the basis of these results a suggestion for the definition of the concrete strut angle for torsion design in relation to DIN 1045‐1 is derived. Furthermore a design concept for the definition of the thickness of the shear flow zone is presented. Finally the database is analysed according to Eurocode 2 in its edition of April 2002.     

Review essay

Berlin — myth and model: on the production of German planning ideology in Berlin. Mythos Berlin. (Exhibition catalogue)¹ Berlin, 1987. ISBN 3 88245 147 5.

Mythos Berlin. (Concepte)² Berlin, 1986. ISBN 3 88245 139 4.

Die Zukunft der Metropolen: Paris ? London ? New York ? Berlin. (Exhibition catalogue) (3 Volumes) Berlin, 1984. ISBN 3 496 00805 9.

Weltstadt Berlin. Ilse Balg (Ed.), Galerie Wannsee Verlag, Berlin, 1986.

Platz frei für das Neue Berlin! Geschichte der Stadterneuerung in der ‘größten Mietskasernenstadt der Welt’ seit 1871. Harald Bodenschatz, Transit‐Verlag, Berlin, 1987. 288 pp, DM48, ISBN 3 887 47038 9.     

Trial and error

A pac-learning algorithm isd-space bounded, if it stores at mostd examples from the sample at any time. We characterize thed-space learnable concept classes. For this purpose we introduce the compression parameter of a concept classb and design our Trial and Error Learning Algorithm. We show: b isd-space learnable if and only if the compression parameter ofb is at mostd. This learning algorithm does not produce a hypothesis consistent with the whole sample as previous approaches e.g. by Floyd, who presents consistent space bounded learning algorithms, but has to restrict herself to very special concept classes. On the other hand our algorithm needs large samples; the compression parameter appears as exponent in the sample size. We present several examples of polynomial time space bounded learnable concept classes:

- all intersection closed concept classes with finite VC-dimension.

- convexn-gons in ?².

- halfspaces in ?ⁿ.

- unions of triangles in ?².

We further relate the compression parameter to the VC-dimension, and discuss variants of this parameter.     

High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice

Ad libitum-fed diets high in fat and carbohydrate (especially fructose) induce weight gain, obesity, and nonalcoholic fatty liver disease (NAFLD) in humans and animal models. However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates expression of liver fatty acid binding protein (L-FABP)—a protein intimately involved in fatty acid and glucose regulation of lipid metabolism. Wild-type (WT) and L-fabp gene ablated (LKO) mice were pair-fed either high-fat diet (HFD) or high-fat/high-glucose diet (HFGD) wherein total carbohydrate was maintained constant but the proportion of glucose was increased at the expense of fructose. In LKO mice, the pair-fed HFD increased body weight and lean tissue mass (LTM) but had no effect on fat tissue mass (FTM) or hepatic fatty vacuolation as compared to pair-fed WT counterparts. These LKO mice exhibited upregulation of hepatic proteins in fatty acid uptake and cytosolic transport (caveolin and sterol carrier protein-2), but lower hepatic fatty acid oxidation (decreased serum β-hydroxybutyrate). LKO mice pair-fed HFGD also exhibited increased body weight; however, these mice had increased FTM, not LTM, and increased hepatic fatty vacuolation as compared to pair-fed WT counterparts. These LKO mice also exhibited upregulation of hepatic proteins in fatty acid uptake and cytosolic transport (caveolin and acyl-CoA binding protein, but not sterol carrier protein-2), but there was no change in hepatic fatty acid oxidation (serum β-hydroxybutyrate) as compared to pair-fed WT counterparts.     

Electronic properties of low temperature microcrystalline silicon carbide prepared by Hot Wire CVD

Microcrystalline silicon carbide (μc-SiC) was prepared at low substrate temperatures using Hot Wire chemical vapor deposition (HWCVD). High crystalline volume fractions were achieved at high hydrogen dilution and high deposition pressure. Without intentional doping, such material shows high dark conductivity and high optical absorption below the band gap. The material prepared at low deposition pressure or low hydrogen dilution, on the other hand, shows much lower conductivity and sub-gap absorption, but high spin densities up to 5 × 10¹⁹ cm⁻³. This high absorption can be attributed to free carriers, different to μc-Si:H where a correlation between the sub-gap absorption and the spin density is observed.     

Co-Training by Committee: A Generalized Framework for Semi-Supervised Learning with Committees

Many data mining applications have a large amount of data but labeling data is often di cult, expensive, or time consuming, as it requires human experts for annotation.Semi-supervised learning addresses this problem by using unlabeled data together with labeled data to improve the performance. Co-Training is a popular semi-supervised learning algorithm that has the assumptions that each example is represented by two or more redundantly su cient sets of features (views) and additionally these views are independent given the class. However, these assumptions are not satis ed in many real-world application domains. In this paper, a framework called Co-Training by Committee (CoBC) is proposed, in which an ensemble of diverse classi ers is used for semi-supervised learning that requires neither redundant and independent views nor di erent base learning algorithms. The framework is a general single-view semi-supervised learner that can be applied on any ensemble learner to build diverse committees. Experimental results of CoBC using Bagging, AdaBoost and the Random Subspace Method (RSM) as ensemble learners demonstrate that error diversity among classi ers leads to an e ective Co-Training style algorithm that maintains the diversity of the underlying ensemble.