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21.
Children with sickle-cell anaemia are predisposed to thrombotic strokes, the aetiology of which is unclear. We propose that erythropoietin, produced in response to chronic anaemia, is responsible for changes in platelet reactivity with a resulting increase in thromboses. This hypothesis is based on reports of enhanced aggregability of erythropoietin-driven platelets and an increased rate of thrombosis in patients receiving large doses of recombinant erythropoietin. Experiments in animals have shown that erythropoietin stimulates synthesis of platelets, that erythropoietin-driven platelets are hyper-reactive compared with age-matched control platelets, and that erythropoietin is pro-thrombotic. These data suggest that erythropoietin-dependent changes in platelet reactivity may potentiate thrombosis in sickle-cell anaemia, particularly in children who, compared with adults, have markedly higher erythropoietin concentrations and incidence of strokes. 相似文献
22.
Florian Seidel Clemens Hage Martin Kleinsteuber 《Machine Vision and Applications》2014,25(5):1227-1240
An increasing number of methods for background subtraction use Robust PCA to identify sparse foreground objects. While many algorithms use the \(\ell _1\) -norm as a convex relaxation of the ideal sparsifying function, we approach the problem with a smoothed \(\ell _p\) -quasi-norm and present pROST, a method for robust online subspace tracking. The algorithm is based on alternating minimization on manifolds. Implemented on a graphics processing unit, it achieves realtime performance at a resolution of \(160 \times 120\) . Experimental results on a state-of-the-art benchmark for background subtraction on real-world video data indicate that the method succeeds at a broad variety of background subtraction scenarios, and it outperforms competing approaches when video quality is deteriorated by camera jitter. 相似文献
23.
The usefulness of Software Architecture (SA) documentation depends on how well its Architectural Knowledge (AK) can be retrieved by the stakeholders in a software project. Recent findings show that the use of ontology-based SA documentation is promising. However, different roles in software development have different needs for AK, and building an ontology to suit these needs is challenging. In this paper we describe an approach to build an ontology for SA documentation. This approach involves the use of typical questions for eliciting and constructing an ontology. We outline eight contextual factors, which influence the successful construction of an ontology, especially in complex software projects with diverse AK users. We tested our ‘typical question’ approach in a case study and report how it can be used for acquiring and modeling AK needs. 相似文献
24.
"A Practice-Based Bioethic" is a regular column in Advanced Practice Nursing Quarterly. A practice-based approach is derived from, and therefore is intended to be appropriate to, the situation of a patient, the purpose of the health care setting, and the role of the nurse. It is based on a shared state of awareness, the foundation on which ethical interactions between nurse and patient occur. 相似文献
25.
F Gonzalez RL Walton B Shafer WE Matory GL Borah 《Canadian Metallurgical Quarterly》1993,91(7):1270-1276
The condition macromastia has not been defined and characterized precisely by the medical community. Whether the patient with hypertrophic breasts is a candidate for or can be helped by reduction mammaplasty is unclear to both the medical and the lay community. A prospective study of 39 women undergoing reduction mammaplasty surgery was initiated to answer these questions. Patients rated the severity of their somatic pain symptoms and discomfort before reduction mammaplasty and again after complete recovery. The severity of their symptoms and complaints was numerically graded and analyzed. These data were compared with similar data obtained from 40 "small-breasted" women of similar age. Headache, neck pain, back pain, shoulder pain, and bra strap groove pain were present in 60 to 92 percent of patients, and 97 percent of patients had at least three of these pain symptoms preoperatively. All the patients had reduction of their pain symptomatology postoperative, and 25 percent of the study patients had total elimination of pain symptoms by reduction mammaplasty. The postoperative incidence and severity of pain symptoms and discomfort complaints were statistically equivalent to or less than the levels in the control group. 相似文献
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In this note, we extend our studies on finite element Galerkin schemes for elliptic variational inequalities of first to the one of second kind. Especially we perform the corresponding a posteriori error analysis for a simple friction problem and a model flow of a Bingham fluid. 相似文献
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GL McIntire ER Bacon JL Toner JB Cornacoff PE Losco KJ Illig KJ Nikula BA Muggenburg L Ketai 《Canadian Metallurgical Quarterly》1998,87(11):1466-1470
Lung cancer continues to be a leading cause of death around the world. Staging of this disease is critically dependent upon the involvement or noninvolvement of the lymph nodes which drain the region of lung containing the lesion/tumor. Palpation, unenhanced CT, and lymph node excision (i.e., mediastinectomy) are currently used to ascertain the status of these regional draining lymph nodes. The work reported herein details the first efforts toward the pulmonary instillation of iodinated nanoparticles for contrast-enhanced CT of lung draining lymph nodes. The data reflect the impact of dose, time post instillation, and formulation (surfactant) upon the observed CT enhancement of the tracheobronchial lymph nodes of beagle dogs. In addition, initial safety is discussed with both macroscopic and microscopic observations. The results indicate that pulmonary instillation of small volumes of iodinated nanoparticles could be successfully used to aid staging of lung cancer by CT imaging. 相似文献
30.
GL Clayman AK el-Naggar SM Lippman YC Henderson M Frederick JA Merritt LA Zumstein TM Timmons TJ Liu L Ginsberg JA Roth WK Hong P Bruso H Goepfert 《Canadian Metallurgical Quarterly》1998,16(6):2221-2232
PURPOSE: Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not significantly improved survival over the last 30 years. Preclinical studies showed that adenoviral vector delivery of the wild-type p53 gene reduced tumor growth in mouse xenograft models. Our purpose was to ascertain the safety and therapeutic potential of adenoviral (Ad)-p53 in advanced HNSCC. PATIENTS AND METHODS: Patients with incurable recurrent local or regionally metastatic HNSCC received multiple intratumoral injections of Ad-p53, either with or without tumor resection. Patients were monitored for adverse events and antiadenoviral antibodies, tumors were monitored for response and p53 expression, and body fluids were analyzed for Ad-p53. RESULTS: Tumors of 33 patients were injected with doses of up to 1 x 10(11) plaque-forming units (pfu). No dose-limiting toxicity or serious adverse events were noted. p53 expression was detected in tumor biopsies despite antibody responses after Ad-p53 injections. Clinical efficacy could be evaluated in 17 patients with nonresectable tumors: two patients showed objective tumor regressions of greater than 50%, six patients showed stable disease for up to 3.5 months, and nine patients showed progressive disease. One resectable patient was considered a complete pathologic response. Ad-p53 was detected in blood and urine in a dose-dependent fashion, and in sputum. CONCLUSION: Patients were safely injected intratumorally with Ad-p53. Objective antitumor activity was detected in several patients. The infectious Ad-p53 in body fluids was asymptomatic, and suggests that systemic or regional treatment may be tolerable. These results suggest the further investigation of Ad-p53 as a therapeutic agent for patients with HNSCC. 相似文献