On the performance of voltage stepping for the simulation of adaptive, nonlinear integrate-and-fire neuronal networks

In traditional event-driven strategies, spike timings are analytically given or calculated with arbitrary precision (up to machine precision). Exact computation is possible only for simplified neuron models, mainly the leaky integrate-and-fire model. In a recent paper, Zheng, Tonnelier, and Martinez (2009) introduced an approximate event-driven strategy, named voltage stepping, that allows the generic simulation of nonlinear spiking neurons. Promising results were achieved in the simulation of single quadratic integrate-and-fire neurons. Here, we assess the performance of voltage stepping in network simulations by considering more complex neurons (quadratic integrate-and-fire neurons with adaptation) coupled with multiple synapses. To handle the discrete nature of synaptic interactions, we recast voltage stepping in a general framework, the discrete event system specification. The efficiency of the method is assessed through simulations and comparisons with a modified time-stepping scheme of the Runge-Kutta type. We demonstrated numerically that the original order of voltage stepping is preserved when simulating connected spiking neurons, independent of the network activity and connectivity.     

Responses of single and group piles within MSE walls under static and cyclic lateral loads

To investigate the behavior of piles and the performance of the mechanically stabilized earth (MSE) walls under static and cyclic lateral loading, six reduced-scale model tests of single and group piles within the MSE walls were conducted inside a test box. In the single pile tests, a hollow aluminum tube as a pile was placed at a distance of 2D or 4D (D is pile diameter) behind the wall facing, while in the group pile tests, the piles were only placed at the distance of 2D with a spacing of 3.3D between the piles. The piles were subjected to static lateral loading only and cyclic lateral loading followed by static loading until failure. The test results showed that the lateral load capacity of each pile in the group pile test was approximately 60% that of the single pile, while the wall facing displacements and the geogrid strains in the group pile test were larger than those in the single pile test. The lateral pile capacity, the wall facing displacement, the strain in the geogrid, and the lateral earth pressure behind the wall facing in the static and cyclic loading tests were evaluated at the pile head displacement equal to 20%D.     

Modification of Fatty Acid,Essential Oil and Phenolic Contents of Salt‐Treated Sweet Marjoram (Origanum majorana L.) According to Developmental Stage

Abstract: Variation in the composition of Origanum majorana L. essential oil (EO) and fatty acids were studied under salt treatment. Plant material has been harvested at 2 phenological stages: early vegetative stage (EVS) and late vegetative stage (LVS) or prefloral. Our results showed that the application of 75 mM NaCl increased total lipid contents in marjoram shoots and caused great qualitative changes in the fatty acids profiles. NaCl treatment reduced and stimulated the EO yields, respectively, at EVS and LVS and induced quantitative changes in the chemical EO composition in shoots. Phenolic contents were higher during the LVS than EVS in the absence and the presence of salt. Under control conditions, RP‐HPLC analysis of the methanolic extract of marjoram dried shoots showed a predominance of flavonoid during the EVS whereas phenolic acids predominated during the LVS. However, under 75 mM NaCl, we noted a predominance of flavonoid at LVS and constant levels of phenolic and flavonoid classes at the EVS. For control treatment and at both EVS and LVS, the main components identified were respectively rosmarinic acid gallic as phenolic acids and amentoflavone as flavonoid. In the presence of salt and at the EVS, we observed a significant increase in trans‐2 hydrocinnamic, gallic acid and quercetin‐3‐galactoside contents. However, for the LVS, salt induced a stimulation of gallic acid, apigenin, and amentoflavone. Our results showed that LVS had the highest contents of bioactive compounds, and could be considered as the best stage for harvesting marjoram plants. Practical Application: In this study, the fatty acid composition, essential oil, and phenolic content of Origanum majorana were investigated. This is important for potential application of marjoram as functional food at the late vegetative stage. The richness of O. majorana in volatile and phenolic active compounds known for their antioxidant, antimicrobial, and insecticidal activities could support the utilization of this plant in a large field of application including cosmetic, pharmaceutical, agro alimentary, and biological defense.     

A tamper-proof and lightweight authentication scheme

We present a tamper-proof and lightweight challenge-response authentication scheme, based on 2-level noisy Physically Unclonable Functions (PUF). We present a security reduction, which shows the scheme to be secure against passive attacks, provided that it is hard to learn a threshold of halfspaces under the uniform distribution. Furthermore, we provide an extensive analysis of PUFs. In particular, we thoroughly derive a linear model for delay based PUFs, and finally we explore extensions of PUFs to produce efficient and tamper-resilient n-to-n mappings.     

A 126.6-mm2 AND-type 512-Mb flash memory with 1.8-Vpower supply

A 512-Mb flash memory, which is applicable to removable flash media of portable equipment such as audio players, has been developed. The chip is fabricated with a 0.18-μm CMOS process on a 126.6-mm² die, and uses a multilevel technique (2 bit/1 cell). The memory cell is AND-type, which is suitable for multilevel operation. This paper reports new techniques adopted in the 512-Mb flash memory. First, techniques for low voltage operation are described. The charge pump, control of pumps, and the reference voltage generator are improved to generate internal voltage stably for multilevel flash memory. Next, a method for reducing total memory cost in the removable flash media is described. A new operation mode named read-modify-write is introduced on the chip. This feature makes the memory system simple, because the controller does not have to track sector-erase information     

Antioxidant and antithrombotic effects of green mussels (Perna canaliculus) in rats

In the past decade, the use of marine mussels as seafood is being more popular. They considered being a rich source of various nutritional bioactive compounds that aroused the scientific community's interest. This study investigated the antioxidant and the antithrombotic consequences on Sprague-Dawley male rats after adding dried New Zealand mussel Perna canaliculus in their diet. The biochemical, hematological and histopathological changes were also observed. Forty rats were divided into four groups according to the amount of dried mussels in their diet, in addition to a control group that consumed a basal diet only. Group 1 consumed 25% dried mussels in its basal diet; Group 2 consumed 35% dried mussels in its basal diet, and Group 3 was consumed 45% dried mussels in its basal diet. The biochemical parameters showed improvements in liver function. Interestingly, the lipid profile decreased, especially the low-density lipoprotein cholesterol (LDL-C) levels which were reduced significantly in Group 3 (p < .01). These observations were accompanied by a decrease in iron levels significantly as the amount of dried mussels increased (p < .01). Furthermore, the noticed changes in the hematological profile prove that there is an increase in antithrombotic activity. Dried mussels had potent antioxidant effects in the liver as shown by increased lipid peroxide (p < .05), reduced glutathione (p < .05), and glutathione peroxidase (GSH-Px; p < .05). Additionally, antioxidant activity in the kidney was shown to increase through GSH-Px activity (p < .01). In conclusion, these results indicate that consuming dried mussels resulted in improved biochemical and antioxidants activities and could be used as an antithrombotic agent.     

Exact and approximate methods for parallel multiple-area spatial scheduling with release times

Spatial scheduling problems involve scheduling jobs that each require certain amounts of two-dimensional space within a processing area of limited width and length. Thus, this requires not only assigning time slots to each job but also locations and orientations within the limited physical processing space as well. Such problems, often encountered in shipbuilding and aircraft manufacturing, are generally difficult to solve, and there is a relatively small amount of literature addressing these problems compared to other types of scheduling. In this paper, we consider a particularly complex class of spatial scheduling problems that involve scheduling each job into one of several possible processing areas in parallel to minimize the total amount of tardy time. In addition, each job has a release time before which it may not be processed. We introduce two methods for solving this type of problem: an integer programming (IP) model and a heuristic algorithm. We perform computational tests and comparisons of each method over a large number of generated benchmark problems with varying characteristics, and also compare these to a more naïve heuristic. Solving the IP model was effective for small problems but required excessive amounts of time for larger ones. The heuristic was effective and produced solutions of comparable quality to the IP model for many problems while requiring very little computational time.     

Salt effect on phenolics and antioxidant activities of Tunisian and Canadian sweet marjoram (Origanum majorana L.) shoots

BACKGROUND: Two varieties of Origanum majorana (Canadian and Tunisian) were evaluated for their phenolic, flavonoid and tannin contents, individual phenolic compounds and antioxidant activities under NaCl constraint. RESULTS: The results showed a significant variability in phenolic composition and antioxidant behavior between the two varieties under salt stress. The phenolic composition of methanolic extracts was determined by reversed‐phase high‐performance liquid chromatography. Amentoflavone was the predominant flavonoid compound; in addition, trans‐2‐hydrocinnamic acid became the major phenolic acid with salt treatment of the Tunisian variety. In the control, Canadian variety extract was characterized by high levels of gallic acid and amentoflavone. However, under 75 mmol L^?1 NaCl, gallic acid content doubled, whereas amentoflavone content was maintained in the Canadian variety. Stimulation of phenolic acid biosynthesis was observed in these two varieties under salt treatment despite the fact that shoots of the Tunisian variety showed higher antioxidant activities compared to those from the Canadian variety. Tunisian O. majorana might have developed tolerance to salinity and avoided tissue damage by activating enzymes involved in the galactosylation of quercetin into quercetin‐3‐galactoside and quercetin‐3‐rhamnoside. CONCLUSION: Our results confirmed the tolerance of Tunisian O. majorana plants. Copyright © 2012 Society of Chemical Industry     

Pesticide residues in fruits and vegetables in Jordan using liquid chromatography/tandem mass spectrometry

A total of 158 fruit and vegetable samples produced in Jordan were examined for the presence of pesticide residues using the multi-residue analysis technique by Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) and the QuEchERS extraction method. A total of 73 samples (46%) were free from detectable residues, while 85 samples (54%) contained residues. Among the tested samples, 34 (22%) contained residues above Maximum Residue Levels (MRLs) and 51 (32%) contained residues at or below MRLs. Most of the detected residues were found in sweet pepper, peach and apricot samples. Only watermelon samples were free from detectable residues, while tomato and melon samples exhibited residues below MRLs. Out of the 113 pesticides tested, 22 pesticides were found above the limit of detection, 9 of which (hexaconazole, propargite, propiconazole, myclobutanil, thiamethoxam, thiacloprid, clothianidin, clofentezine and pyridaben) had residues that violate MRLs according to European regulations. A continuous monitoring programme for pesticide residues in Jordanian fruits and vegetables is highly recommended.     

ROI-Driven Cyber Risk Mitigation Using Host Compliance and Network Configuration

Automated cyber security configuration synthesis is the holy grail of cyber risk management. The effectiveness of cyber security is highly dependent on the appropriate configuration hardening of heterogeneous, yet interdependent, network security devices, such as firewalls, intrusion detection systems, IPSec gateways, and proxies, to minimize cyber risk. However, determining cost-effective security configuration for risk mitigation is a complex decision-making process because it requires considering many different factors including end-hosts’ security weaknesses based on compliance checking, threat exposure due to network connectivity, potential impact/damage, service reachability requirements according to business polices, acceptable usability due to security hardness, and budgetary constraints. Although many automated techniques and tools have been proposed to scan end-host vulnerabilities and verify the policy compliance, existing approaches lack metrics and analytics to identify fine-grained network access control based on comprehensive risk analysis using both the hosts’ compliance reports and network connectivity. In this paper, we present new metrics and a formal framework for automatically assessing the global enterprise risk and determining the most cost-effective security configuration for risk mitigation considering both the end-host security compliance and network connectivity. Our proposed metrics measure the global enterprise risk based on the end-host vulnerabilities and configuration weaknesses, collected through compliance scanning reports, their inter-dependencies, and network reachability. We then use these metrics to automatically generate a set of host-based vulnerability fixes and network access control decisions that mitigates the global network risk to satisfy the desired Return on Investment of cyber security. We solve the problem of cyber risk mitigation based on advanced formal methods using Satisfiability Module Theories, which has shown scalability with large-size networks.