Immunoreactivity, stability, pharmacokinetics and biodistribution of a monoclonal antibody to human leukemic B cells after three different methods of radioiodination

Dal B02, a murine monoclonal antibody against human chronic lymphocytic leukemia (CLL) was radioiodinated using chloramine T (Chl.T), Bolton-Hunter (B-H) or N-succinimidyl-p-iodobenzoate (PIB). The preparations had comparable radiochemical purity (> 97%) and immunoreactive fraction (65-80%) but the Chl.T-based product was most susceptible to deiodination and loss of immunoreactivity. After i.v. injection into CLL-xenografted nude mice, the preparations had identical patterns of clearance from the blood but the PIB-based product led to more radioactivity in liver and spleen and less in the thyroid compared to the other preparations. The Chl.T-based product showed loss of immunoreactivity in circulation and less tumor-localized radioactivity 168 h after administration. The differences between the B-H-based and PIB-based products were less impressive than between PIB-based and Chl.T-based products.     

Synthesis and characterisation of polyol-capped transition metal oxide nanoparticles

In-situ capped nanocrystalline gamma-Fe2O3, Co3O4, and Cu2O were prepared in 1,4-butanediol in aerobic conditions. X-ray diffraction (XRD) patterns show that the synthesised samples are nanocrystalline cubic oxides with crystallite sizes 9.5 nm, 13.4 nm, and 11 nm, respectively. Raman spectroscopy shows peaks at 350 cm(-1), 500 cm(-1), and 700 cm(-1), indicating that the iron oxide is gamma-Fe2O3; M?ssbauer spectroscopy shows the presence of two Fe3(3+) sites. Transmission electron microscopy images show that the particle sizes of gamma-Fe2O3 and Co3O4 samples are 8.9 nm and 7 nm, respectively. The absence of agglomeration indicates that the synthesised nanoparticles are capped. FT-IR spectra show the presence of an organic moiety in the sample which acts as a capping agent. Thermogravimetry shows that the capping is stable up to 873 K in gamma-Fe2O3, and up to 400 K in Co3O4. The samples are soluble in water to form stable hydrosols. During synthesis of gamma-Fe2O3 a 6-line ferrihydrite is formed as an intermediate, which is stable in solution up to 473 K, and transforms to gamma-Fe2O3 at 483 K, by rapid dissolution-reprecipitation. In the syntheses of Co3O4 and Cu2O, no intermediates are formed.     

Distribution of sulphur in coal seams with special reference to the Tertiary coals of North-Eastern India

This investigation makes a systematic study of the distribution of the forms of sulphur in the Tertiary coals of North-Eastern India, i.e. coals of Upper Assam and Arunachal Pradesh, to delineate the areas of low sulphur content and high sulphur content with a low proportion of organic sulphur. These coals have, in general, a high sulphur content. In a particular seam, total-, pyritic- and organic-sulphur contents increase from the floor to the roof of the seam. Upper seams are found to contain, in general, more sulphur than the seams lying below. Certain sections of a seam have low organic sulphur contents which can be mined separately. It is possible to delineate the low sulphur zones in a particular coalfield so assisting the scientific exploration and exploitation.     

VSAT networks in India—specifications and applications

This paper describes briefly the evolution of VSATs in India, including the existing and proposed networks and their applications. The salient specifications of the various types of VSATs are described. Some of the VSATs under advanced stages of development as well as those to be used in proposed networks due for implementation soon are also covered.     

Iterated Belief Change

Most existing formalizations treat belief change as a single-step process, and ignore several problems that become important when a theory, or belief state, is revised over several steps. This paper identifies these problems, and argues for the need to retain all of the multiple possible outcomes of a belief change step, and for a framework in which the effects of a belief change step persist as long as is consistently possible. To demonstrate that such a formalization is indeed possible, we develop a framework, which uses the language of PJ-default logic (Delgrande and Jackson 1991) to represent a belief state, and which enables the effects of a belief change step to persist by propagating belief constraints . Belief change in this framework maps one belief state to another, where each belief state is a collection of theories given by the set of extensions of the PJ-default theory representing that belief state. Belief constraints do not need to be separately recorded; they are encoded as clearly identifiable components of a PJ-default theory. The framework meets the requirements for iterated belief change that we identify and satisfies most of the AGM postulates (Alchourrón, Gärdenfors, and Makinson 1985) as well.     

Correlating antenna array

A set of arbitrarily located receiving antenna elements, each connected with an appropriate network, can be used to construct a matched filter where the antenna array response results in an autocorrelation of a specified desired signal, correlating over time and space coordinates simultaneously. A receiving system using such a signal processing antenna can discard interferences which do not have the same spectral characteristics as the desired signal, or which do not originate from the same point as the desired signal source. Examples of correlating antenna arrays for various arbitrary intelligence modulations of the desired signal are discussed in this communication.     

An Unusual Form of Belite in Portland Cement Clinker

Potassium-rich structures around the edge of a fissure in a portland cement clinker have been found to have compositional and structural properties similar to those of dendritic bellies. However, the potassium levels surprisingly exceed the accepted solubility limit.