Antioxidant vitamins and prevention of cardiovascular disease: Epidemiological and clinical trial data

Naturally occurring antioxidants such as vitamin E, β-carotene, and vitamin C can inhibit the oxidative modification of low density lipoproteins. This action could positively influence the atherosclerotic process and, as a consequence, the progression of coronary heart disease. A wealth of experimental studies provide a sound biological rationale for the mechanisms of action of antioxidants, whereas epidemiologic studies strongly sustain the “antioxidant hypothesis”. To date, however, clinical trials with β-carotene supplements have been disappointing, and their use as a preventive intervention for cancer and coronary heart disease should be discouraged. Only scanty data from clinical trials are available for vitamin C. As to vitamin E, discrepant results have been obtained by the Alpha-Tocopherol, Beta Carotene Cancer Prevention Study with a low-dose vitamin E supplementation (50 mg/d) and the Cambridge Heart Antioxidant Study (400–800 mg/d). The results of the GISSI-Prevenzione (300 mg/d) and HOPE (400 mg/d) trials suggest the absence of relevant clinical effects of vitamin E on the risk of cardiovascular events. Currently ongoing are several large-scale clinical trials that will help in clarifying the role of vitamin E in association with other antioxidants in the prevention of atherosclerotic coronary disease.     

Ray-chaotic footprints in deterministic wave dynamics: a test model with coupled Floquet-type and ducted-type mode characteristics

Ray chaos, manifested by the exponential divergence of trajectories in an originally thin ray bundle, can occur even in linear electromagnetic propagation environments, due to the inherent nonlinearity of ray-tracing maps. In this paper, we present a novel (two-dimensional) test example of such an environment which embodies intimately coupled refractive wave-trapping and periodicity-induced multiple scattering phenomenologies, and which is amenable to explicit full-wave analysis. Though strictly nonchaotic, it is demonstrated that under appropriate conditions which are inferred from a comprehensive parametric database generated via the above-noted rigorous reference solution, the high-frequency wave dynamics exhibits trends toward irregularity and other peculiar characteristics; these features can be interpreted as "ray-chaotic footprints", and they are usually not observed in geometries characterized by "regular" ray behavior. In this connection, known analogies from other disciplines (particularly quantum physics) are briefly reviewed and related to the proposed test configuration. Moreover, theoretical implications and open issues are discussed, and potential applications are conjectured.     

Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity

Graphene and other 2D materials, such as molybdenum disulfide, have been increasingly used in electronics, composites, and biomedicine. In particular, MoS₂ and graphene hybrids have attracted a great interest for applications in the biomedical research, therefore stimulating a pertinent investigation on their safety in immune cells like macrophages, which commonly engulf these materials. In this study, M1 and M2 macrophage viability and activation are mainly found to be unaffected by few‐layer graphene (FLG) and MoS₂ at doses up to 50 µg mL^?1. The uptake of both materials is confirmed by transmission electron microscopy, inductively coupled plasma mass spectrometry, and inductively coupled plasma atomic emission spectroscopy. Notably, both 2D materials increase the secretion of inflammatory cytokines in M1 macrophages. At the highest dose, FLG decreases CD206 expression while MoS₂ decreases CD80 expression. CathB and CathL gene expressions are dose‐dependently increased by both materials. Despite a minimal impact on the autophagic pathway, FLG is found to increase the expression of Atg5 and autophagic flux, as observed by Western blotting of LC3‐II, in M1 macrophages. Overall, FLG and MoS₂ are of little toxicity in human macrophages even though they are found to trigger cell stress and inflammatory responses.     

Effect of ageing on the morphology and creep and recovery of polymer-modified bitumens

Polymer additives are used to improve the properties of road bitumens including their oxidative resistance. However, their usage as anti-oxidative materials remains relatively unclear. This study aims to investigate the changes in the morphology and the rheological response of polymer modified bitumens used in road pavement construction caused by ageing. An elastomer (radial styrene butadiene styrene, SBS) and a plastomer (ethyl vinyl acetate, EVA) polymer were mixed with one base bitumen at three polymer concentrations. The bitumens were RTFO and PAV aged. The morphology of the bitumens was captured by fluorescence microscopy while the rheological properties were measured by means of the multiple stress creep and recovery (MSCR) test. The results show that the morphology of the SBS modified bitumen degrades with ageing as a function of polymer concentration and dispersion, with higher dispersion being more resistant. The morphology of the EVA modified bitumen has a low ageing susceptibility irrespective of polymer concentration. The MSCR response of EVA modified bitumens does not differ from that found for unmodified bitumen, where the hardening produces a decrease in the non-recoverable compliance. In the case of SBS modified bitumen, the degradation of the polymer backbone affects the bitumen hardening as much as the polymer phase dispersed and networked in the bitumen phase. Furthermore, in the case of the elastomer, the average percent recovery is in agreement with the variation of the morphology with ageing. Therefore, the use of the average percent recovery as a valuable rheological index of the integrity of the polymer network can be advocated.     

An integrated symbolic/connectionist architecture for parsing italian sentences containing pp-attachment ambiguities

This paper describes a hybrid (symbolic/connectionist) system that performs PP-attachment disambiguation by taking advantage of three distinguishing features of neutral networks: distributed representation, functional compositionality, and inductive learning. The connectionist part of the system follows all the steps performed by the symbolic parser, and drives the parser's behavior by inducing a bias towards the most semantically plausible attachment choices. The sentence to be parsed is read one word at a time. When the symbolic parser has more than one production to apply, the connectionist module has already developed an inner representation of the sentence and a distribution of probabilities over the possible choices. The parser continues its work according to such a distribution.     

A domain decomposition technique for finite element based parametric sweep and tolerance analyses of microwave passive devices

A domain decomposition approach is here applied to the finite element solution of a multiport waveguide passive device. The approach allows separating the problem in multiple, coupled subproblems which can be solved individually. By appropriately defining one of these subdomains as containing all the possible variations to be studied it is hence possible to restrict the tolerance analysis to this latter, smaller domain. Numerical results showing the gain in computing time are presented. © 2008 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2009.     

Combining Deduction and Model Checking into Tableaux and Algorithms for Converse-PDL

This paper presents a prefixed tableaux calculus for Propositional Dynamic Logic with Converse based on a combination of different techniques such as prefixed tableaux for modal logics and model checkers for μ-calculus. We prove the correctness and completeness of the calculus and illustrate its features. We also discuss the transformation of the tableaux method (naively NEXPTIME) into an EXPTIME algorithm.     

Mobile JikesRVM: A framework to support transparent Java thread migration

Today’s complex applications must face the distribution of data and code among different network nodes. Computation in distributed contexts is demanding increasingly powerful languages and execution environments, able to provide programmers with appropriate abstractions and tools. Java is a wide-spread language that allows developers to build complex software, even distributed, but it cannot handle the migration of computations (i.e. threads), due to intrinsic limitations of many traditional JVMs. After analyzing the approaches in the literature, this paper presents our thread migration framework (called Mobile JikesRVM), implemented on top of the IBM Jikes Research Virtual Machine (RVM): exploiting some of the innovative techniques in the JikesRVM, we implemented an extension of its scheduler that allows applications to easily capture the state of a running thread and makes it possible to restore it elsewhere (i.e. on a different hardware architecture or operating system), but still with a version of the framework installed). Our thread serialization mechanism provides support for both proactive and reactive migration, available also for multi-threaded Java applications, and tools to deal with the problems of resource relocation management. With respect to previous approaches, we implemented Mobile JikesRVM without recompiling its JVM (Java Virtual Machine) source code, but simply extending JikesRVM functionalities with a full Java package to be imported when thread migration is needed.