Support environment for active rule design

The lack of tools for rule generation, analysis, and run-time monitoring appears one of the main obstacles to the widespreading of active database applications. This paper describes a complete tool environment for assisting the design of active rules applications; the tools were developed at Politecnico di Milano in the context of the IDEA Project, a 4-years Esprit project sponsored by the European Commission which was launched in June 1992. We describe tools for active rule generation, analysis, debugging, and browsing; rules are defined in Chimera, a conceptual design model and language for the specification of active rules applications. We also introduce a tool for mapping from Chimera into Oracle, a relational product supporting triggers.Most of the tools described in this paper are fully implemented and currently in operation (beta-testing) within the companies participating to the IDEA Project, with the exception of two of them (called Argonaut-V and Pandora), which will be completed by the end of 1996.Research presented in this paper is supported by Esprit project P6333 IDEA, and by ENEL contract VDS 1/94: Integrity Constraint Management     

CAD based shape optimization for gas turbine component design

In order to improve product characteristics, engineering design makes increasing use of Robust Design and Multidisciplinary Design Optimisation. Common to both methodologies is the need to vary the object’s shape and to assess the resulting change in performance, both executed within an automatic loop. This shape change can be realised by modifying the parameter values of a suitably parameterised Computer Aided Design (CAD) model. This paper presents the adopted methodology and the achieved results when performing optimisation of a gas turbine disk. Our approach to hierarchical modelling employing design tables is presented, with methods to ensure satisfactory geometry variation by commercial CAD systems. The conducted studies included stochastic and probabilistic design optimisation. To solve the multi-objective optimisation problem, a Pareto optimum criterion was used. The results demonstrate that CAD centric approach enables significant progress towards automating the entire process while achieving a higher quality product with the reduced susceptibility to manufacturing imperfections.     

Knowledge representation and inference techniques to improve the management of gas and oil facilities

This paper describes an experimental work carried out in the framework of an important European project to create and make use of a wide-ranging knowledge base in the gas/oil domain. In the context of this work, “knowledge base” means a collection of formal statement relating, with a negligible loss of information, the inner content (the ‘meaning’) of “complex events” included in two different “storyboards”. These events – originally presented under the form of unstructured natural language information – concern some general activities proper to the management of gas/oil facilities, like recognizing and monitoring gas leakage alarms in a gas processing plant or triggering the different steps needed to activate a gas turbine. To express this sort of information and to set up the knowledge base, the NKRL (Narrative Knowledge Representation Language) formalism has been used. NKRL is a conceptual meta-model and Computer Science environment expressly created to deal, in an ‘intelligent’ and complete way, with complex and content-rich ‘narrative’ data sources. The final knowledge base has been firstly tested in depth using the standard NKRL querying and information retrieval tools. High-level inference procedures have then been used, both “transformation rules” – unsuccessful queries are ‘transformed’ to produce results that are ‘semantically similar’ to those searched for initially – and “hypothesis rules” – information in the knowledge base is automatically aggregated to supply a sort of ‘causal’ explanation of some retrieved events.     

Construct validation of the Rorschach Reality-Fantasy Scale in alexithymia.

The study applies Winnicott's conceptualization of potential space to the alexithymia construct by using a new Rorschach index, the Reality-Fantasy Scale (RFS). The scale uses variables derived from the Rorschach Comprehensive System (Exner, 2000, 2001) to detect different types of psychopathological manifestations conceptualized as forms of collapse of potential space. Following previous research, the present study further evaluates the construct validity of the RFS in a sample of 92 patients with inflammatory bowel disease, categorized on the basis of the Toronto Alexithymia Scale (TAS-20) as alexithymic, indeterminate alexithymia, and nonalexithymic groups. As hypothesized, the RFS significantly correlated with the TAS-20, discriminated among the 3 groups, and showed incremental validity in detecting alexithymia over isolated Rorschach markers. The study supports the exploration of psychoanalytic ideas by empirical, statistically based methods. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rheological studies with spherically shaped thin liquid films

The present work shows the first experimental and theoretical results for investigations on the rheology of liquid films. The experiments are planned to be performed under microgravity conditions. This environment will allow forming films of different thickness, which is impossible under ground conditions due to drainage. Then the films are forced to harmonic oscillations of the film area so that the film elasticity can be measured as a function of frequency. The presented theoretical model demonstrates the main relationships to be solved under corresponding boundary conditions     

Reasoning with infinite stable models

This paper illustrates extensively the theoretical properties, the implementation issues, and the programming style underlying finitary programs. They are a class of normal logic programs whose consequences under the stable model semantics can be effectively computed, despite the fact that finitary programs admit function symbols (hence infinite domains) and recursion. From a theoretical point of view, finitary programs are interesting because they enjoy properties that are extremely unusual for a nonmonotonic formalism, such as compactness. From the application point of view, the theory of finitary programs shows how the existing technology for answer set programming can be extended from problem solving below the second level of the polynomial hierarchy to all semidecidable problems. Moreover, finitary programs allow a more natural encoding of recursive data structures and may increase the performance of credulous reasoners.     

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Peritoneal dialysis (PD) represents the dialysis modality of choice for pediatric patients with end-stage kidney disease. Indeed, compared with hemodialysis (HD), it offers many advantages, including more flexibility, reduction of the risk of hospital-acquired infections, preservation of residual kidney function, and a better quality of life. However, despite these positive aspects, PD may be associated with several long-term complications that may impair both patient’s general health and PD adequacy. In this view, chronic inflammation, caused by different factors, has a detrimental impact on the structure and function of the peritoneal membrane, leading to sclerosis and consequent PD failure both in adults and children. Although several studies investigated the complex pathogenic pathways underlying peritoneal membrane alterations, these processes remain still to explore. Understanding these mechanisms may provide novel approaches to improve the clinical outcome of pediatric PD patients through the identification of subjects at high risk of complications and the implementation of personalized interventions. In this review, we discuss the main experimental and clinical experiences exploring the potentiality of the proteomic analysis of peritoneal fluids and extracellular vesicles as a source of novel biomarkers in pediatric peritoneal dialysis.     

Design für Kostentransparenz in Anlageberatungsgespr?chen

Investment advisory services of financial service providers (FSPs) exhibit several characteristics that are detrimental to advisory quality. The interaction of advisor and client is strained by a lack of transparency regarding the advisory process (what activities are performed and why) and the information used therein (what information is used for what purpose and with what effect), as well as regarding the precise costs of the service and the recommended products. In prior research, we suggested that process and information transparency issues may be appropriately addressed with collaborative information technology (IT) artifacts. In this paper, we argue that collaborative, transparent artifacts may also be a premise of enabling cost transparency. To this end, we describe a complete research cycle of designing, implementing, and evaluating a shared cost-transparent IT artifact to support client-advisor interaction in investment advisory encounters. Evaluation results suggest the efficacy of our design in improving the clients?? perceived cost transparency as well as increase their satisfaction and their willingness to pay for the received investment advice. These findings may also challenge the common belief of FSPs that transparent, fee-based advisory services would neither be accepted by clients nor be economically viable. Practical implications of these findings for designing advisory encounters with supportive IT are discussed.     

Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes

Intestinal cell dysfunctions involved in obesity and associated diabetes could be correlated with impaired intestinal cell development. To date, the molecular mechanisms underlying these dysfunctions have been poorly investigated because of the lack of a good model for studying obesity. The main aim of this study was to investigate the effects of lipotoxicity on intestinal cell differentiation in small intestinal organoid platforms, which are used to analyze the regulation of cell differentiation. Mouse intestinal organoids were grown in the presence/absence of high palmitate concentrations (0.5 mM) for 48 h to simulate lipotoxicity. Palmitate treatment altered the expression of markers involved in the differentiation of enterocytes and goblet cells in the early (Hes1) and late (Muc2) phases of their development, respectively, and it modified enterocytes and goblet cell numbers. Furthermore, the expression of enteroendocrine cell progenitors (Ngn3) and I cells (CCK) markers was also impaired, as well as CCK-positive cell numbers and CCK secretion. Our data indicate, for the first time, that lipotoxicity simultaneously influences the differentiation of specific intestinal cell types in the gut: enterocytes, goblet cells and CCK cells. Through this study, we identified novel targets associated with molecular mechanisms affected by lipotoxicity that could be important for obesity and diabetes therapy.