Finance and the technology-trade nexus

This paper sketches the contours of the evolving international/monetary system and examines the various roles of the intemediation mechanisms. Then it examines the extent to which the financial system is independent from the “real economy” and the various ways in which it impacts it. The paper discusses some views in good currency on the dynamics of the technology-trade-finance nexus and shows how the financial system influences organization, location and technology choices in meso-innovation systems. The final section of the paper looks at the policy implications that might be derived from the analysis and suggests some directions for the future research.     

Modélisation de la cinétique de biodégradation de phénol par granules aérobies

This work describes a model of the biodegradation of phenol carried out by aerobic granules. These granules were obtained by culturing an activated sludge supernatant in a sequencing batch reactor fed with a synthetic waste water and subsequently, by acclimation to phenol (100 mg/L). The kinetics of phenol biodegradation by the aerobic granules was investigated over a wide range of initial phenol concentrations (40–1112 mg/L) in shake‐flask cultures. A Haldane‐type model was adjusted to the experimental results, which depicts successfully the phenol biodegradation profiles in the entire range of initial concentrations studied by using only one set of parameters. It is our view that the proposed model could contribute to the knowledge about the ability of aerobic granular systems to biodegrade toxic, inhibitory compounds such as phenol.     

Three‐dimensional localization for the MagneBike inspection robot

The MagneBike inspection robot is a climbing robot equipped with magnetic wheels. The robot is designed to drive on three‐dimensional (3D) complexly shaped pipe structures; therefore it is necessary to provide 3D visualization tools for the user, who remotely controls the robot out of sight. The localization system is required to provide a 3D map of the unknown environment and the 3D location of the robot in the environment's map. The localization strategy proposed in this paper consists of combining 3D odometry with 3D scan registration. The odometry model is based on wheel encoders and a three‐axis accelerometer. Odometry enables the tracking of the robot trajectory between consecutive 3D scans and is used as a prior for the scan matching algorithm. The 3D scan registration facilitates the construction of a 3D map of the environment and refines the robot position computed with odometry. This paper describes in detail the implementation of the localization concept. It presents the lightweight, small‐sized 3D range finder that has been developed for the MagneBike. It also proposes an innovative 3D odometry model that estimates the local surface curvature to compensate for the absence of angular velocity inputs. The different tools are characterized in detail based on laboratory and field experiments. They show that the localization concepts reliably track the robot moving in the specific application environment. We also describe various techniques to optimize the 3D scanning process, which is time consuming, and to compensate for the identified limitations. These techniques are useful inputs for the future automatization of the robot's control and optimization of its localization process. © 2010 Wiley Periodicals, Inc.     

Approximation of functions by perceptrons: a new approach

We provide a constructive proof of the theorem of function approximation by perceptrons (cf Leshno et al. [1], Hornik [2]) when the activation function ψ isC∞ with all its derivatives non 0 at 0. We deal with uniform approximation on compact sets of continuous functions on ℜ ^d ,d≥1. This approach is elementary and provides some approximation results for the derivatives along with some bounds for the hidden layer.     

Correlation between machining direction,cutter geometry and step-over distance in 3-axis milling: Application to milling by zones

Computer-Aided Manufacturing (CAM) occupies an increasingly important role in engineering with all it has to offer in terms of new possibilities and improving designer/manufacturer productivity. The present study addresses machining of free-form surfaces on a 3-axis NC machine tool. There have recently been a large number of studies devoted to planning tool paths on free-form surfaces with various strategies being adopted. These strategies are intended to increase efficiency by reducing the overall length of machining. Often, the choice of the cutter is arbitrary and the work focuses on planning. In order to boost productivity, the present work offers assistance in choosing the cutting tool, the machining direction and cutting by surface zones, adopting a milling strategy by parallel planes. To do so, a comparison is made between milling using a spherical end milling cutter and a torus end milling cutter with the same outer radius. This comparison relates to the radius of curvature of the trace left by the cutter at the point of contact between the tool and the workpiece in relation to the direction of feed motion.     

Bis(dipyridophenazine)(2‐(2′‐pyridyl)pyrimidine‐4‐carboxylic acid)ruthenium(II) Hexafluorophosphate: A Lesson in Stubbornness

Ruthenium complexes are currently considered to be among the most promising alternatives to platinum anticancer drugs. In this work, thirteen structural analogues and organelle/receptor‐targeting peptide bioconjugates of a cytotoxic bis(dppz)‐Ru^II complex [Ru(dppz)₂(CppH)](PF₆)₂ ( 1 ) were prepared, characterized, and assessed for their cytotoxicity and cellular localization (CppH=2‐(2′‐pyridyl)pyrimidine‐4‐carboxylic acid; dppz=dipyrido[3,2‐a:2′,3′‐c]phenazine). It was observed that structural modifications (lipophilicity, charge, and size‐based) result in the cytotoxic potency of 1 being compromised. Confocal microscopy studies revealed that unlike 1 , the screened complexes/bioconjugates do not have a preferential accumulation in mitochondria. The results of this important structure–activity relationship strongly support our initial hypothesis that accumulation in mitochondria is crucial for 1 to exert its cytotoxic action.     

Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model

The primary objective of this study was to develop a computer-aided method for the quantification of three-dimensional (3-D) cartilage changes over time in knees with osteoarthritis (OA). We introduced a local coordinate system (LCS) for the femoral and tibial cartilage boundaries that provides a standardized representation of cartilage geometry, thickness, and volume. The LCS can be registered in different data sets from the same patient so that results can be directly compared. Cartilage boundaries are segmented from 3-D magnetic resonance (MR) slices with a semi-automated method and transformed into offset-maps, defined by the LCS. Volumes and thickness are computed from these offset-maps. Further anatomical labeling allows focal volumes to be evaluated in predefined subregions. The accuracy of the automated behavior of the method was assessed, without any human intervention, using realistic, synthetic 3-D MR images of a human knee. The error in thickness evaluation is lower than 0.12 mm for the tibia and femur. Cartilage volumes in anatomical subregions show a coefficient of variation ranging from 0.11% to 0.32%. This method improves noninvasive 3-D analysis of cartilage thickness and volume and is well suited for in vivo follow-up clinical studies of OA knees.     

Characterisation of carbon blacks produced by solar thermal dissociation of methane

Solar methane dissociation appears as a possible route toward a hydrogen-based economy. The competitiveness of the process strongly depends on the carbon black properties and economic value. At CNRS-PROMES, a 50 kW tubular solar reactor was developed to produce carbon black and hydrogen from methane. The reaction was carried out in a graphite receiver crossed by seven graphite tubes heated up by concentrated solar radiations at the 1 MW CNRS solar furnace. The temperatures ranged between 1608 K and 1928 K and the methane flow-rates varied from 10.5 to 21 NL/min. Total methane dissociation was reached with hydrogen yield higher than 80% and the carbon yield was drastically affected by the acetylene by-product. The carbon samples were analysed in detail and their properties were compared to a commercial conductive grade carbon black. Transmission electron microscopy showed primary particles of 10–70 nm diameter. The crystallinity of the samples was characterised by Raman spectroscopy. It was also possible to correlate the specific surface area with the reaction temperature and with the concentrations of residual methane and of the acetylene by-product. The resistivity and the structure of the agglomerates were determined by simultaneous measurements of the conductivity and the density under compression.