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51.
Synthesis,Pharmacological Evaluation,and Docking Studies of Novel Pyridazinone‐Based Cannabinoid Receptor Type 2 Ligands 下载免费PDF全文
Dr. Giulio Ragusa Dr. Serena Bencivenni Dr. Paula Morales Dr. Tyra Callaway Dr. Dow P. Hurst Dr. Battistina Asproni Dr. Stefania Merighi Dr. Giovanni Loriga Prof. Gerard A. Pinna Prof. Patricia H. Reggio Prof. Stefania Gessi Prof. Gabriele Murineddu 《ChemMedChem》2018,13(11):1102-1114
In recent years, cannabinoid type 2 receptors (CB2R) have emerged as promising therapeutic targets in a wide variety of diseases. Selective ligands of CB2R are devoid of the psychoactive effects typically observed for CB1R ligands. Based on our recent studies on a class of pyridazinone 4‐carboxamides, further structural modifications of the pyridazinone core were made to better investigate the structure–activity relationships for this promising scaffold with the aim to develop potent CB2R ligands. In binding assays, two of the new synthesized compounds [6‐(3,4‐dichlorophenyl)‐2‐(4‐fluorobenzyl)‐cis‐N‐(4‐methylcyclohexyl)‐3‐oxo‐2,3‐dihydropyridazine‐4‐carboxamide ( 2 ) and 6‐(4‐chloro‐3‐methylphenyl)‐cis‐N‐(4‐methylcyclohexyl)‐3‐oxo‐2‐pentyl‐2,3‐dihydropyridazine‐4‐carboxamide ( 22 )] showed high CB2R affinity, with Ki values of 2.1 and 1.6 nm , respectively. In addition, functional assays of these compounds and other new active related derivatives revealed their pharmacological profiles as CB2R inverse agonists. Compound 22 displayed the highest CB2R selectivity and potency, presenting a favorable in silico pharmacokinetic profile. Furthermore, a molecular modeling study revealed how 22 produces inverse agonism through blocking the movement of the toggle‐switch residue, W6.48. 相似文献
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Quinone‐Fused Pyrazoles through 1,3‐Dipolar Cycloadditions: Synthesis of Tricyclic Scaffolds and in vitro Cytotoxic Activity Evaluation on Glioblastoma Cancer Cells 下载免费PDF全文
Giulio Bertuzzi Simone Crotti Pierpaolo Calandro Bianca Flavia Bonini Ilaria Monaco Erica Locatelli Mariafrancesca Fochi Paolo Zani Elena Strocchi Prof. Andrea Mazzanti Dr. Mario Chiariello Prof. Mauro Comes Franchini 《ChemMedChem》2018,13(17):1744-1750
A novel and straightforward synthesis of highly substituted isoquinoline‐5,8‐dione fused tricyclic pyrazoles is reported. The key step of the synthetic sequence is a regioselective, Ag2CO3 promoted, 1,3‐dipolar cycloaddition of C‐heteroaryl‐N‐aryl nitrilimines and substituted isoquinoline‐5,8‐diones. The broad functional group tolerability and mild reaction conditions were found to be suitable for the preparation of a small library of compounds. These scaffolds were designed to interact with multiple biological residues, and two of them, after brief synthetic elaborations, were analyzed by molecular docking studies as potential anticancer drugs. In vitro studies confirmed the potent anticancer effects, showing promising IC50 values as low as 2.5 μm against three different glioblastoma cell lines. Their cytotoxic activity was finally positively correlated to their ability to inhibit PI3K/mTOR kinases, which are responsible for the regulation of diverse cellular processes in human cancer cells. 相似文献
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Giovanni Di Nicola Giuliano Giuliani Fabio Polonara Giulio Santori Roman Stryjek 《International Journal of Thermophysics》2010,31(10):1880-1887
A recently built experimental setup was employed for the estimation of the solid–liquid equilibria of alternative refrigerant systems. In this paper two binaries, i.e., carbon dioxide + trifluoromethane (CO2 + R23) and nitrous oxide + trifluoromethane (N2O + R23), were studied down to temperatures of 117 K. In order to check the reliability of the apparatus, the triple points of the pure fluids contained in the mixture were measured, revealing good consistency with the literature. The results obtained for the mixtures were interpreted by means of the Schröder equation. 相似文献
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Marco Sangermano Giulio Malucelli Gabriele Delleani Aldo Priola 《Polymer International》2007,56(10):1224-1229
A commercially available bicyclo‐orthoester (BOE) was used as low‐shrinkage additive for cationic UV curing of epoxy resins. A high reactivity of BOE by ring‐opening homopolymerization has been observed under cationic UV curing conditions. The BOE and trimethylolpropane triglycidyl ether monomers are compatible and give rise to a cured copolymeric network, under UV irradiation, with a flexibilization increase by increasing the BOE content in the photocurable formulation. Shrinkage after photopolymerization shows a linear reduction by increasing the BOE content in the photocurable formulation; a volume expansion upon polymerization is reached in the presence of 50 wt% of the additive. Copyright © 2007 Society of Chemical Industry 相似文献
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Giulia Bernardini Maurizio Comanducci Stefania Bambini Giovanni Renzone Andrea Scaloni Giovanna Morelli Mark Achtman Giulio Ratti Annalisa Santucci 《Proteomics. Clinical applications》2009,3(10):1251-1254
We previously described the first reference map for the proteome of one strain of serogroup A Neisseria meningitidis (MenA), a major cause of epidemic meningitis in humans. As a preliminary finding, in that work we noted that 2‐DE protein maps of closely related MenA isolates from different epidemics spreads could be easily compared to detect minor differences and that 2‐DE phenotypes attributable to the well‐known epidemiological marker tbpB agreed with the genoclouds model of MenA epidemiological variation during pandemic waves. We explored here the possibility that an extended comparative study of 2‐DE maps of isolates representative of the nine genoclouds described by Achtman and collaborators could be used to discriminate between strains otherwise undistinguishable. We showed the example of 14 proteins with different 2‐DE spot patterns in different genoclouds that could be considered as putative tracers for alike‐strains discrimination. We introduce the novel concept that comparative proteomics can be useful in identifying new epidemiological markers for N. meningitidis. 相似文献
59.
The execution of workflow processes requires authorizations for enforcing the assignment of tasks to agents, either human or automated, according to the security policy of the organization. This paper presents a workflow authorization framework based on roles and organizational levels, and on authorization constraints. To facilitate the assignment of tasks to agents, roles and organizational levels are organized into hierarchies. Authorization constraints are introduced to specify instance-dependent, time-dependent, and history-dependent authorizations. Authorization constraints are specified in terms of active rules, used also for authorization management. The Workflow Management System determines authorized agents on the basis of the contents of an authorization base maintained through the active rules defined in the system. 相似文献
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