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Presented are the results of an experimental study on the response forces and damping values of a model of a five storeyed building frame and its five equivalent single degree mode-models during free and forced vibrations on a vibration bed. 相似文献
103.
Brianna Benedict McIntyre;Kelsey Scalaro;Allison Godwin;Adam Kirn;Dina Verdín; 《工程教育杂志》2024,113(4):1265-1286
Students' recognition beliefs have emerged as one of the most important components of engineering role identity development for early-career undergraduate students. Recognition beliefs are students' perceptions of how meaningful others, such as peers, instructors, and family, see them as engineers. However, little work has investigated the experiences that facilitate recognition beliefs, particularly across the intersections of race, ethnicity, and gender. Investigation of these experiences provides ways to understand how recognition may be supported in engineering environments and how White and masculine norms in engineering can shape marginalized students' experiences. 相似文献
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Michela Cerone Dr. Elisa Uliassi Dr. Federica Prati Dr. Godwin U. Ebiloma Dr. Leandro Lemgruber Prof. Christian Bergamini Dr. David G. Watson Thais de A. M. Ferreira Gabriella Simões Heyn Roth Cardoso Prof. Luiz A. Soares Romeiro Prof. Harry P. de Koning Prof. Maria Laura Bolognesi 《ChemMedChem》2019,14(6):621-635
In the search for effective and sustainable drugs for human African trypanosomiasis (HAT), we developed hybrid compounds by merging the structural features of quinone 4 (2-phenoxynaphthalene-1,4-dione) with those of phenolic constituents from cashew nut shell liquid (CNSL). CNSL is a waste product from cashew nut processing factories, with great potential as a source of drug precursors. The synthesized compounds were tested against Trypanosoma brucei brucei, including three multidrug-resistant strains, T. congolense, and a human cell line. The most potent activity was found against T. b. brucei, the causative agent of HAT. Shorter-chain derivatives 20 (2-(3-(8-hydroxyoctyl)phenoxy)-5-methoxynaphthalene-1,4-dione) and 22 (5-hydroxy-2-(3-(8-hydroxyoctyl)phenoxy)naphthalene-1,4-dione) were more active than 4 , displaying rapid micromolar trypanocidal activity, and no human cytotoxicity. Preliminary studies probing their mode of action on trypanosomes showed ATP depletion, followed by mitochondrial membrane depolarization and mitochondrion ultrastructural damage. This was accompanied by reactive oxygen species production. We envisage that such compounds, obtained from a renewable and inexpensive material, might be promising bio-based sustainable hits for anti-trypanosomatid drug discovery. 相似文献
106.
Nanostructure engineering has been proved to be an efficient approach for improving electrochemical properties for energy storage by accommodating volume changes, facilitating rapid mass transport paths, and enlarging ion storage sites and interfaces. The well‐designed fine nanostructures, unfortunately, are usually destroyed during long‐term cycles and ultimately lose their structural advantages. Herein, stimulated by the extraordinary structural stability, robust mechanical properties, and salient ventilation capacity of natural honeycomb species, bioinspired heterogeneous bimetallic Co–Mo oxide (CoMoOx) nanoarchitectures assembled from 2D nanounits are successfully fabricated via a molybdenum‐mediated self‐assembly strategy for improving the rate capability of electrochemical lithium storage devices. Owing to the robust structural stability and the ultrathin 2D wall structure, CoMoOx nanostructures present well‐maintained honeycomb‐like structure, rapid capacitive insertion–desertion behaviors, and thus significantly enhanced lithium ion storage performance at high rates (5.0 A g−1). It is also revealed that the reversible transition of cobalt and molybdenum phases closely associated with the ultrathin 2D wall structures greatly contribute to the outstanding electrochemical lithium storage performances. This attractive integration of structural and functional advantages achieved by learning from nature offers new insights into the design of cost‐effective electrode materials for high‐performance energy devices. 相似文献
107.
Olutoyin A. Fashae Adeyemi O. Olusola Ijeoma Ndubuisi Christopher Godwin Udomboso 《河流研究与利用》2019,35(2):169-177
Many attempts have been made in the recent past to model and forecast streamflow using various techniques with the use of time series techniques proving to be the most common. Time series analysis plays an important role in hydrological research. Traditionally, the class of autoregressive moving average techniques models has been the statistical method most widely used for modelling water discharge, but it has been shown to be deficient in representing nonlinear dynamics inherent in the transformation of runoff data. In contrast, the relatively newly improved and efficient soft computing technique artificial neural networks has the capability to approximate virtually any continuous function up to an arbitrary degree of accuracy, which is not otherwise true of other conventional hydrological techniques. This technique corresponds to human neurological system, which consists of a series of basic computing elements called neurons, which are interconnected together to form networks. The aim of the study is to compare the artificial neural network and autoregressive integrated moving average to model River Opeki discharge (1982–2010) and to use the best predictor to forecast the discharge of the river from 2010 to 2020. The performance of the two models was subjected to statistical test based on correlation coefficient (r) and the root‐mean‐square error. The result showed that autoregressive integrated moving average performs better considering the level of root‐mean‐square error and higher correlation coefficient. 相似文献
108.
Rishi Man Chugh Payel Bhanja Ximena Diaz Olea Fang Tao Kealan Schroeder Ryan Zitter Tanu Arora Harsh Pathak Bruce F. Kimler Andrew K. Godwin John M. Perry Subhrajit Saha 《International journal of molecular sciences》2022,23(10)
Radiation-induced loss of the hematopoietic stem cell progenitor population compromises bone marrow regeneration and development of mature blood cells. Failure to rescue bone marrow functions results in fatal consequences from hematopoietic injury, systemic infections, and sepsis. So far, bone marrow transplant is the only effective option, which partially minimizes radiation-induced hematopoietic toxicities. However, a bone marrow transplant will require HLA matching, which will not be feasible in large casualty settings such as a nuclear accident or an act of terrorism. In this study we demonstrated that human peripheral blood mononuclear cell-derived myeloid committed progenitor cells can mitigate radiation-induced bone marrow toxicity and improve survival in mice. These cells can rescue the recipient’s hematopoietic stem cells from radiation toxicity even when administered up to 24 h after radiation exposure and can be subjected to allogenic transplant without GVHD development. Transplanted cells deliver sEVs enriched with regenerative and immune-modulatory paracrine signals to mitigate radiation-induced hematopoietic toxicity. This provides a natural polypharmacy solution against a complex injury process. In summary, myeloid committed progenitor cells can be prepared from blood cells as an off-the-shelf alternative to invasive bone marrow harvesting and can be administered in an allogenic setting to mitigate hematopoietic acute radiation syndrome. 相似文献
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Oliver W. Gramlich Cheyanne R. Godwin David Wadkins Benjamin W. Elwood Markus H. Kuehn 《International journal of molecular sciences》2021,22(14)
Glaucoma is a leading cause of irreversible blindness worldwide, and increased intraocular pressure (IOP) is a major risk factor. We aimed to determine if early functional and molecular differences in the glaucomatous retina manifest before significant retinal ganglion cell (RGC) loss is apparent. Adenoviral vectors expressing a pathogenic form of myocilin (Ad5.MYOC) were used to induce IOP elevation in C57BL/6 mice. IOP and pattern electroretinograms (pERG) were recorded, and retinas were prepared for RNA sequencing, immunohistochemistry, or to determine RGC loss. Ocular injection of Ad5.MYOC leads to reliable IOP elevation, resulting in significant loss of RGC after nine weeks. A significant decrease in the pERG amplitude was evident in eyes three weeks after IOP elevation. Retinal gene expression analysis revealed increased expression for 291 genes related to complement cascade, inflammation, and antigen presentation in hypertensive eyes. Decreased expression was found for 378 genes associated with the γ-aminobutyric acid (GABA)ergic and glutamatergic systems and axon guidance. These data suggest that early functional changes in RGC might be due to reduced GABAA receptor signaling and neuroinflammation that precedes RGC loss in this glaucoma model. These initial changes may offer new targets for early detection of glaucoma and the development of new interventions. 相似文献