CO2 hydrate: Modeling of incipient stability conditions and dissociation enthalpy

In this study, CO₂ hydrate incipient stability zone in pure water is modelled employing an empirical tool, classification and regression tree, least squares support vector machine, and adaptive neuro-fuzzy inference system. Furthermore, a new semi-theoretical model is developed to estimate CO₂ hydrate dissociation enthalpy. Moreover, the quality of CO₂ hydrate's experimental data is assessed through a thermodynamic-based and Leverage approaches. Results revealed that: (1) the proposed models provide satisfactory predictions; (2) there are some doubtful data in the database; (3) outcomes of the developed semi-theoretical model for estimating the CO₂ hydrate dissociation enthalpy are in good agreement with previous works.     

Simultaneous design of optimal gait pattern and controller for a bipedal robot

Nowadays, biped robotics becomes an interesting topic for many control researchers. The biped robot is more adaptable than the other mobile robots in a varied environment and can have more diverse possibilities in planning the motion. However, it falls down easily and its control for stable walking is difficult. Therefore, generation of a desired walking pattern for the biped robot in the presence of some model uncertainties is an important problem. The proposed walking pattern should be also achievable by the designed controller. To achieve this aim and to reach the best control performance, the walking pattern and controller should be designed simultaneously rather than separately. In the present study, an optimal walking pattern is proposed to be tracked by a designed sliding mode controller. In this respect, a genetic algorithm (GA) is utilized to determine the walking pattern parameters and controller coefficients simultaneously. Here, high stability, minimum energy consumption, good mobility properties, and actuator limitations are considered as the important indexes in optimization. Simulation results indicate the efficiency of the proposed scheme in walking the understudy biped robot.     

Volume-aware positioning in the context of a marine port terminal

The rapid proliferation of mobile computing devices and local wireless networks over the past few years has promoted a continuously growing interest in location-aware systems and applications. The main problem with existing positioning techniques is that they are designed to position dimensionless objects. Such an assumption may lead to practical inconsistencies, as it results in neglecting the effects of the volume of an object, its physical characteristics, and its spatial arrangement on signal propagation. In this paper, we consider the problem of positioning cargo containers in a marine port terminal, where such characteristics can be finely estimated. Based on the signal propagation map of a container yard, we propose VAPS, a volume-aware positioning system that takes advantage of the waveguide effect generated by the containers. Although VAPS is specific to the marine port scenario, its design principles can be extended and adapted to other situations. VAPS maps discrete RSSI levels into hop-counts and relies on realistic propagation models to obtain near-perfect positioning at a very low control overhead. Our extensive evaluations show how to set the parameters required in the VAPS algorithm. The results demonstrate that, in scenarios where the assumptions made by traditional approaches fail, the considerations of VAPS make the difference.     

Employing secure coding practices into industrial applications: a case study

Industrial Control Systems (ICS) are the vital part of modern critical infrastructures. Recent attacks to ICS indicate that these systems have various types of vulnerabilities. A large number of vulnerabilities are due to secure coding problems in industrial applications. Several international and national organizations like: NIST, DHS, and US-CERT have provided extensive documentation on securing ICS; however proper details on securing software application for industrial setting were not presented. The notable point that makes securing a difficult task is the contradictions between security priorities in ICS and IT systems. In addition, none of the guidelines highlights the implications on modification of general IT security solutions to industrial settings. Moreover based on the best of our knowledge, steps to develop a successful real-world secure industrial application have not been reported. In this paper, the first attempts to employ secure coding best practices into a real world industrial application (Supervisory Control and Data Acquisition) called OpenSCADA is presented. Experiments indicate that resolving the vulnerabilities of OpenSCADA in addition to possible improvement in its availability, does not jeopardize other dimensions of security. In addition, all experiments are backed up with proper statistical tests to see whether or not, improvements are statistically significant.     

Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus-specific tear secretory immunoglobulin A than systemic vaccination and provides protection against recurrent spontaneous ocular shedding of virus in latently infected rabbits

Rabbits latently infected with herpes simplex virus type 1 (HSV-1) were vaccinated either periocularly or systemically with a subunit vaccine (gB2 + gD2) plus adjuvant or adjuvant alone. Tear films were collected daily to measure recurrent infectious HSV-1 shedding. After systemic vaccination, the latently infected rabbits were not protected against recurrent ocular viral shedding (HSV-1-positive tear film cultures/total cultures) compared with either the systemic or periocular adjuvant controls (systemic vaccination = 49 of 972, 5.0%; systemic control = 46 of 972, 4.7%; periocular control = 43 of 930, 4.6%; P > 0.8). In contrast, latently infected rabbits vaccinated periocularly with the same vaccine had significantly reduced recurrent shedding (20 of 1026, 2.0%) compared with controls (P < 0.001) or systemic vaccination (P = 0.0002). Thus, recurrent HSV-1 shedding was significantly reduced by therapeutic local periocular subunit vaccination but not by therapeutic systemic subunit vaccination. Neutralizing antibody titers in the serum of systemically and ocularly vaccinated rabbits was similar. In contrast, HSV-specific tear secretory immunoglobulin A was significantly higher in the ocularly vaccinated group (P < 0.01). These results strongly suggest that in the rabbit, and presumably in humans, the local ocular (mucosal) immune response is much more important than the systemic immune response for therapeutic protection against recurrent ocular HSV-1. Thus development of a therapeutic vaccine against recurrent ocular HSV-1 should be directed at enhancing the local ocular (mucosal) immune response.     

A thermo/pH/magnetic-responsive nanogel based on sodium alginate by modifying magnetic graphene oxide: Preparation,characterization, and drug delivery

A novel thermo/pH/magnetic-triple-responsive nanogel was synthesized by grafting N-isopropylacrylamide and acrylic acid onto sodium alginate to modify magnetic graphene oxide as a drug delivery system. The synthesized nanogel was characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS), vibrating sample magnetometer (VSM), atomic force micrographs (AFM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The obtained nanogel displayed excellent reversible transmittance changes in response to pH, temperature, and magnetic field. The performance of the nanogels to load doxorubicin (DOX) drug and to sustain doxorubicin release was tested upon exposure to pH, temperature, and magnetic field variations. The mechanism of drug release was proposed in this paper by different kinetic models. In addition, the effects of nanogels and DOX-loaded nanogels on MCF-7 cells were examined and results were compared with free DOX drug. The in vitro results demonstrated that this triple-responsive nanogel can be an appropriate candidate for applications in cancer therapy.     

Synthesis and in vitro assessment of novel water‐soluble dextran‐docetaxel conjugates as potential pH sensitive system for tumor‐targeted delivery

Docetaxel is a potent taxane agent mostly used in breast, lung, and prostate cancers. Its low water solubility is the major drawback that leads to use of Tween 80 as surfactant and ethanol as solvent in market formulation. But, these excipients cause severe hypersensitivity reactions. In this study, docetaxel was conjugated to biocompatible polymer, dextran 70 kDa, via a pH sensitive linker to enhance solubility and diminish the need of surfactants. Folic acid was also conjugated to dextran to provide targeted delivery. Synthesized conjugates were examined for solubility, hemo‐compatibility, stability, and cytotoxicity on MCF‐7 and MDA‐MB‐231 cell lines. Results showed about 1200‐fold enhancement in water solubility by dextran and 280‐fold by dextran‐folate conjugation. Conjugates released the drug in a pH‐dependent manner and faster hydrolysis was observed in pH 5.4 than physiological pH 7.4. Docetaxel‐dextran conjugates showed proper hemo‐compatibility and presented greater cytotoxicity than docetaxel solution. Higher cytotoxicity was seen in folate conjugated samples and the final conjugates targeted by folate would be suitable novel substitutions for currently marketed formulation. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45457.     

Formation of Porous Polymer Coatings on Complex Substrates Using Vapor Phase Precursors

In this work, porous poly(methacrylic acid) (PMAA) coatings are formed on complex substrates using vapor phase precursors. The porous coatings are created by partially polymerizing solid monomer deposited onto the substrate. The conformality of the porous PMAA coatings is studied on the external and internal surfaces of cylindrical substrates. Flow effects lead to thickness variations in the θ‐direction while thermal gradients and monomer depletion effects lead to thickness variations in the z‐direction. These variations can be reduced by modifying the flow rate of the monomer vapor, by reducing the radiative heat on the substrate, or by increasing the dimension size of the substrate. This work shows that vapor phase processing methods can be a viable alternative to solution phase methods and the observed trends can be utilized in a range of vapor phase technologies to optimize porous coatings for use in tissue engineering, sensors, and separations.

     

Electronic behavior of native oxide films on Ti and TiN during 90-day immersion in electrolytes with different pH levels

This work presents the electronic behavior of Ti and TiN thin films when exposed to electrolytes with pH levels of 2,7 and 13 for 90 days.Staircase potentio-electrochemical impedance spectroscopy tests were performed on the 100-nm Ti and TiN monolithic films,and MottSchottky analysis of these tests was used to determine the films' semiconductive behavior and changes in the donor/acceptor density.In addition,the flat-band potential of each film's surface oxide was also characterized.No attempt was made to control oxide formation,and therefore,these tests reflected the native surfaces of these films.While the TiN films exhibited n-type semiconductivity in all electrolytes,the Ti films only showed n-type behavior in the acidic(pH=2) and neutral(pH=7) electrolytes.The semiconductivity of the Ti films transitioned to p-type during exposure to the basic electrolyte(pH=13) after reaching 60 days.Furthermore,there was a significant increase in the donor densities for both Ti and TiN films when immersed in the basic electrolyte relative to the acidic and neutral electrolytes.