Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus

The VH4-21 (V4-34) gene segment, a member of the VH4 family, is expressed early in B-cell maturation and is utilized by approximately 6% of normal adult B lymphocytes. This prevalence indicates an importance of VH4-21 in the B-cell repertoire. The gene also encodes certain autoantibodies being mandatory for pathological IgM anti-red cell antibodies directed against the I/i antigen, and also capable of encoding anti-DNA antibodies. Recognition of I/i antigen or DNA appears to be via two distinct sites on VH, with I/i binding mediated by sequences in the framework region, and DNA binding correlating with the presence of positively charged amino acids in complementarity-determining region 3. However, these positively charged residues appear to suppress the ability of the framework region to interact with I/i, rendering a single sequence monospecific for I/i or DNA. The IgM anti-DNA antibodies also recognize bacterial lipid A, whereas the anti-I/i antibodies do not, indicating that CDR3 may be involved in binding the negatively charged lipid A. Structural similarities between the DNA backbone and lipid A provide a possible explanation for this cross-reactivity. This dual recognition of bacterial antigen and autoantigen provides a potential link between infection and autoimmunity.     

Nonlinear filtering structure for image smoothing in mixed-noise environments

This paper introduces a new nonlinear filtering structure for filtering image data that have been corrupted by both impulsive and nonimpulsive additive noise. Like other nonlinear filters, the proposed filtering structure uses order-statistic operations to remove the effects of the impulsive noise. Unlike other filters, however, nonimpulsive noise is smoothed by using a maximum a posteriori estimation criterion. The prior model for the image is a novel Markov random-field model that models image edges so that they are accurately estimated while additive Gaussian noise is smoothed. The Markov random-field-based prior is chosen such that the filter has desirable analytical and computational properties. The estimate of the signal value is obtained at the unique minimum of the a posteriori log likelihood function. This function is convex so that the output of the filter can be easily computed by using either digital or analog computational methods. The effects of the various parameters of the model will be discussed, and the choice of the predetection order statistic filter will also be examined. Example outputs under various noise conditions will be given.     

便携机的法律缺陷

便携媒体播放机促成了更多的无意识盗版行为,未经许可复制DVD与制作音频C D副本一样是违法的。     

Impact of Preferential P-Diffusion Along the Grain Boundaries on Fine-Grained Polysilicon Solar Cells

Thin-film polysilicon solar cells are a promising low-cost alternative for bulk silicon solar cells due to their reduced material thickness. Recently, we showed that the use of an amorphous silicon/polycrystalline silicon heterojunction emitter instead of a diffused homojunction emitter led to a boost in the open-circuit voltage by 90 mV. Now, we present a full evidence that shows that this improvement is related to the absence of dopant smearing along the grain boundaries. By using scanning spreading resistance microscopy, we found an enlargement of the junction area by a factor of five in case of a homojunction. The tips of the dopant spikes represent lowly doped areas with an enhanced recombination.     

An Efficient Code-Based Voxel-Traversing Algorithm

The paper considers an efficient approach to traversing a uniformly-subdivided space pierced by a line segment. A voxel, as the basic constituent element of the uniformly subdivided space, is restricted to having the form of a cube. The algorithm works in two steps. In the first step, the so-called Bresenham voxels are identified and, by comparing their position codes, their type of connectivity is determined. To achieve the required connectivity between neighbouring voxels, the second step of the algorithm is applied to find the missing voxels. In this way, the algorithm efficiently switches between face-, edge- and vertex-connectivity. Although the algorithm works with oating-point precision, it is extremely computationally efficient, and tests of speed compared with the Müller, Cleary & Wyvill, Amanatides & Woo, and Zemčik algorithms are described.     

Spread Spectrum PN Code Acquisition Using Hybrid Correlator Architectures

A hybrid correlator architecture is described which combines the serial structure of an active correlator with the parallel structure of a matched filter correlator. The mean PN code acquisition time performance of this hybrid serial-parallel correlator structure is analysed. Results are shown which compare the acquisition performance of the serial, parallel, and serial-parallel structures. The results are for a PN code length of 64 code chips and assumes a Gaussian channel with the receiver detection threshold set to obtain a constant false alarm rate. An enhancement to the serial-parallel acquisition algorithm is also described which can increase the acquisition time performance by about 15% for typical operating conditions. Overall the results demonstrate that the hybrid correlator can provide rapid code acquisition with a limited receiver complexity.     

A fast analog mean-timer

A circuit is described that determines the average of the transit time of light from an event in a scintillation counter to the two ends of that counter. The design offers superior time resolution and a novel gating scheme that significantly reduces circuit dead-time.     

Further development of the load coefficient method, lcm, for rational seismic design of nuclear facilities

The purpose of this paper is to present the results of a study conducted to compare the results of the Load Coefficient Method, LCM, proposed for seismic load determination, to modal analysis and the equivalent static load methods as defined in Section 3.7.2 of the U.S. Nuclear Regulatory Commission Standard Review Plan. The comparison is conducted using a number of nuclear power plant piping systems which used response spectra modal analysis input in their original design.The real piping systems studied are considered to be representative of ASME Section III nuclear Class 2 and 3 piping systems required to be designed to resist currently defined seismic loadings. Section 2 of this paper provides numerical comparisons of the application of LCM, Response Spectrum and Equivalent Static Load Methods.     

Visual-kinesthetic dissociation in treatment of victims of rape.

A visual–kinesthetic (V–K) dissociation procedure of neurolinguistic programming (NLP) was used in treating rape-induced anxiety and phobic reactions in 2 18- and 19-yr-old rape victims. NLP theory suggests that anxiety reactions experienced by rape victims is a function of the interrelated processes of synesthesia and anchoring. In these 2 case reports, the use of the V–K dissociation technique is explored. From this preliminary basis, further research entailing the use of this treatment procedure is suggested. Implications for clinical practice are noted. (PsycINFO Database Record (c) 2010 APA, all rights reserved)