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81.
A hyperdynamic circulatory state with elevated cardiac output, decreased peripheral vascular resistance, and sodium retention occurs in patients with portal cirrhosis. Surgical portal-systemic shunts and transjugular intrahepatic portal-systemic shunts (TIPS) have been shown to worsen the high-output state in these patients. However, clinical evidence of high-output congestive heart failure has been reported only rarely to complicate cirrhosis. We describe a patient who developed high-output congestive heart failure with markedly elevated filling pressures after TIPS and had complete resolution of heart failure after liver transplantation. 相似文献
82.
Dave McKenney Tony White 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2012,16(2):247-259
This paper investigates the speed improvements available when using a graphics processing unit (GPU) for evaluation of individuals
in a genetic programming (GP) environment. An existing GP system is modified to enable parallel evaluation of individuals
on a GPU device. Several issues related to implementing GP on GPU are discussed, including how to perform tree-based GP on
a device without recursion support, as well as the effect that proper memory layout can have on speed increases when using
CUDA-enabled nVidia GPU devices. The specific GP implementation is designed to evolve stock trading strategies using technical
analysis indicators. The second goal of this research is to investigate the possible improvement in performance when training
individuals on a larger number of stocks and training days. This increased training size (nearly 100,000 training points)
is enabled due to the speedups realized by GPU evaluation. Several different scenarios were used to test various speed optimizations
of GP evaluation on the GPU device, with a peak speedup factor of over 600 (when compared to sequential evaluation on a 2.4 GHz
CPU). Also, it is found that increasing the number of stocks and the length of the training period can result in higher out-of-training
testing profitability. 相似文献
83.
R. Sam Williams Steve Lacher Corey Halpin Christopher White 《Materials and Structures》1988,21(4):313-320
RILEM Bulletin
Fourth International Conference on Durability of Building Materials and Components 相似文献84.
P. S. Sklad C. J. McHargue C. W. White G. C. Farlow 《Journal of Materials Science》1992,27(21):5895-5904
Single crystals of -Al2O3 were implanted with iron ions at room temperature to fluences ranging from 4×1016 Fe cm–2 to 1×1017 Fe cm–2. The microstructure and composition in the implanted region were examined using analytical electron microscopy techniques. Special emphasis was placed on monitoring the microstructural changes which take place during post-implantation annealing. Clusters of metallic -Fe were identified in the specimen after implantation to a dose of 1×1017 Fe cm–2. Analytical electron microscopy of implanted specimens annealed in oxygen revealed the redistribution of the implanted iron and the formation of surface precipitates of -Fe2O3, subsurface precipitates of various forms of spinel, and, in some cases, subsurface precipitates of iron, depending on the annealing temperature. Examination of implanted specimens annealed under reducing conditions revealed the presence of precipitates of -Fe. 相似文献
85.
86.
The method for the detection and possible quantification of the unusual amino acid 3-methyl-l-histidine has been refined and elucidated. This is an essential prerequisite for the determination of its value as a robust unequivocal index of lean meat protein. 相似文献
87.
J. R. White 《Journal of Materials Science》1985,20(7):2377-2387
The layer removal analysis of residual stress distribution is examined for mouldings which contain depth-varying Young's modulus. The approach is to compute the stress distribution which would be derived from the layer removal procedure if the assumption is made that the Young's modulus is uniform, and to compare it with the actual stress distribution. For this analysis a parabolic stress distribution is assumed to be present, and computed distributions are obtained for two cases, (i) in which the modulus varies linearly from the surface to the centre of the moulding and (ii) in which the modulus has a constant value near to the surface (skin) then changes suddenly to another constant value in the interior (core). The general features of the computed profiles are compared with experimental layer removal analyses conducted on injection-moulded specimens and the extent to which non-uniform modulus influences the results of such studies is discussed. 相似文献
88.
D. J. White 《OR Spectrum》1987,9(1):13-22
Summary This paper deals with discounted Markov decision processes, Markov with respect to a finite statespaceI, where for eachiI, and each decision epocht, there is a finite action space K(i, t). The paper is concerned with problems which are formulated in terms of the discounted rewards in several ways. In order to ensure that optimal, or near optimal, policies are obtained, the state spaceI is extended to augmented state-spaces A(n), or A(), including the accumulated discounted rewards. Specimen problems are formulated and some computational aspects examined.
Zusammenfassung Es werden diskontierte Markovsche Entscheidungsprozesse behandelt mit endlichem Zustandsraum I, wobei die Mengen der zulässigen Entscheidungen K(i, t) vom Zustandi I und vom Zeitpunktt abhängen können. Es werden verschiedene Zielfunktionen betrachtet, die jeweils als Funktion des diskontierten Gesamtgewinns (nicht dessen Erwartungswerts) formuliert werden. Um optimale oder fast-optimale Politiken zu erhalten ohne die gesamte Vorgeschichte zu registrieren, wird der Zustandsraum um die akkumulierten diskontierten Auszahlungen erweitert. Eine Auswahl solcher Probleme wird exemplarisch diskutiert einschließlich einiger Aspekte der numerischen Behandlung.相似文献
89.
Summary We integrate two numerical procedures for solving the average reward Markov decision process (MDP), standard successive approximations and modified policy iteration with reward revision. Reward revision is the process of revising the reward structure of a second, more computationally desirable MDP so as to produce, in the limit, an optimality equation having a fixed point identical to that associated with the original MDP. A numerical study indicates that for MDP's having a non-sparse transition structure with a small number of relatively large entries per row, the addition of reward revision can have significant computational benefits.
Research supported by NSF Grant ECS-8319355 相似文献
Zusammenfassung Zur Lösung Markovscher Entscheidungsprozesse (MDP) mit Durchschnitts-Kriterium werden zwei numerische Verfahren, nämlich sukzessive Approximation und modifizierte Politik-Iteration, mit einer Transformation, der sogenannten 'Reward-Revision, kombiniert. Bei dieser Transformation werden die Übergangswahrscheinlichkeiten so abgeändert (ausgedünnt), daß das neue Modell sich numerisch günstiger verhält. Dazu müssen die einstufigen Erträge so revidiert werden, daß die Optimalitäts-Gleichung des neuen Modells im Limes mit der des ursprünglichen übereinstimmt. Numerische Untersuchungen zeigen, daß für MDP mit stark besetzten Übergangsmatrizen, bei denen nur an wenigen Stellen je Zeile große Werte stehen, die Anwendung von 'Reward Revision zu wesentlichen Einsparungen an Rechenaufwand führen kann.
Research supported by NSF Grant ECS-8319355 相似文献
90.
Zhen Zeng Hui Yi Chew Jazmina G. Cruz Graham R. Leggatt James W. Wells 《International journal of molecular sciences》2021,22(6)
T cells play a key role in tumour surveillance, both identifying and eliminating transformed cells. However, as tumours become established they form their own suppressive microenvironments capable of shutting down T cell function, and allowing tumours to persist and grow. To further understand the tumour microenvironment, including the interplay between different immune cells and their role in anti-tumour immune responses, a number of studies from mouse models to clinical trials have been performed. In this review, we examine mechanisms utilized by tumour cells to reduce their visibility to CD8+ Cytotoxic T lymphocytes (CTL), as well as therapeutic strategies trialled to overcome these tumour-evasion mechanisms. Next, we summarize recent advances in approaches to enhance CAR T cell activity and persistence over the past 10 years, including bispecific CAR T cell design and early evidence of efficacy. Lastly, we examine mechanisms of T cell infiltration and tumour regression, and discuss the strengths and weaknesses of different strategies to investigate T cell function in murine tumour models. 相似文献