高压断路器使用SF6气体应注意的若干问题

SF6断路器在超高压电网中被广泛应用。对SF6气体的性能、指标以及使用时应注意的问题进行了分析。     

自焙槽铝电解智能控制下料系统

介绍基于铝电解过程中热平衡和物料平衡原理而设计的一种自动下料系统。这个系统首先在现场总线控制系统上建立一个开放的平台,然后在平台之上建立专家系统,实现自动下料。     

短生命周期产品的供应链仿真框架

文章提出了短生命周期产品的供应链管理的概念,介绍了这种供应链的特点和在管理中存在的问题。在分析其重点过程、性能指标、仿真参数的基础上,给出了短生命周期产品供应链管理的仿真框架,并针对其仿真特点和要求,研究了具有Petri网和面向对象技术特点的复合建模仿真技术。最后以服装业为例,给出了仿真实例。     

基于Web的空气质量远程监控系统

本文提出了一个基于Web的空气质量远程监控系统。系统中监控计算机对现场采集的空气质量数据进行实时监控。并通过Web服务器上的接口和Internet上的客户端建立连接，若有害气体超标。则报警并采取相应的控制措施．以较低的成本实现了现场空气质量的远程监控。     

转炉有效石棉板厚度的计算

对重钢 5 0t转炉进行了炉壳 (炉身段 )温度场分析 ,当石棉板的厚度为 30mm左右时 ,炉壳表面温度就能控制在炉壳材质的蠕变温度以内。     

热电偶的幂函数模型􀀁

本文给出温度测量中热电偶的幂函数数学模型，其拟合精度高，并具有全程一致的良好线性，作为文献「３」的姊妹篇，对工业生产中的温度测量具有更重要的实用价值。     

提高电火花加工热锻模具疲劳抗力的途径

采用能较好模拟热锻模具加载条件的冲击疲劳试验方法,研究了提高电火花加工热锻模具冲击疲劳抗力的工艺途径.结果表明,采用水基工作液电火花加工,电火花加工后高温回火处理及喷丸强化等措施,都可提高试样的冲击疲劳寿命.文中用试验资料合理解释了上述结果,并提出了改善热锻模具疲劳抗力的工艺途径.     

电火花加工表面三维粗糙度的评定基准与评定参数

针对电火花加工表面的特征,分析目前采用切削加工表面粗糙度的评定方法来评定电火花加工表面三维粗糙度的不合理之处,提出改用实际表面算术平均偏差R_(at)和实际表面最大高度R_(yt)两个评定参数来综合评定,并给出相应的取样面积、评定面积和评定基准面及R_(at)和R_(yt)的定义.     

Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes

Recent advances in cancer immunotherapy have exploited the efficient potential of natural killer (NK) cells to kill tumor cells through antibody‐dependent cell‐mediated cytotoxicity (ADCC). However, this therapeutic strategy is seriously limited by tumor antigen heterogeneity since antibodies can only recognize specific antigens. In this work, modified antibodies or their Fc fragments that can target solid tumors without the necessity of specific antigen presentation on tumors are developed. Briefly, Fc fragments or therapeutic monoclonal antibodies are conjugated with the N‐terminus of pH low insertion peptide so that they will selectively assemble onto the membrane of solid tumor cells via the conformational transformation of the peptide by responding to the acidic tumor microenvironment. The inserted Fc fragments or antibodies can efficiently activate NK cells, initiating ADCC and killing multiple types of tumor cells, including antigen‐negative cancer cells. In vivo therapeutic results also exhibit significant efficacy on both primary solid tumors and tumor metastasis. These modified Fc fragments and antibodies present strong potential to overcome the limitation of tumor antigen heterogeneity, broadening the applications of NK cell immunotherapy on solid tumor treatment.     

Biogenetic Vesicle-Based Cancer Vaccines with Tunable Surface Potential and Immune Potency

Cancer vaccines are designed to motivate antigen-specific immune responses and facilitate tumor regression with minimal side effects. To fully exert the potential of vaccines, rationally designed formulations that effectively deliver antigens and trigger potent immune reactions are urgently needed. This study demonstrates a simple and controllable vaccine-developing strategy that assembles tumor antigens into bacterial outer membrane vesicles (OMVs), natural delivery vehicles with intrinsic immune adjuvant properties, via electrostatic interaction. This OMV-delivered vaccine (OMVax) stimulated both innate and adaptive immune responses, leading to enhanced metastasis inhibition and prolonged survival of tumor-bearing mice. Moreover, the influence of different surface charged OMVax on antitumor immunity activation is investigated and declined immune response activation occurred with increased positive surface charge. Together, these findings suggest a simple vaccine formulation that can be enhanced by optimizing the surface charges of vaccine formulations.