New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma

For the first time, we discovered a small proportion of aqueous fraction from Saw Palmetto apart from the fatty acid-rich fraction exhibited pharmacological activity. Therefore, this study aims to explore the anti-tumor potential of red pigmented aqueous fraction of Saw Palmetto, NYG on human hepatocellular carcinoma and its possible targets. Subcutaneous xenograft and orthotopic implantation models of HCC were used to evaluate the tumor inhibitory effect of NYG. Human hepatocellular carcinoma (HCC) cell lines and human umbilical vein endothelial cells (HUVEC) were used as in vitro model. The mRNA expression was conducted by qPCR. Protein expression was monitored by immunoblotting and immunohistochemistry. Cell migration and blood vessel formation were determined by chamber assay and tube formation assay, respectively. Significant tumor inhibition of NYG in dose-dependent manner was observed on subcutaneous xenograft and orthotopic HCC model. NYG has no direct action on cell viability or VEGF secretion of HCC cells. However, NYG reduced in vitro migration and vessel formation activities of HUVEC cells, as well as in vivo intratumoral neovascularization. NYG attenuated extracellular signal-regulated kinases (ERK) activation in endothelial cells, which may be associated with the suppression of migration and tube formation of HUVEC. NYG suppressed tumor expansion of HCC via inhibiting neovascularization, and may be potential adjuvant treatment for HCC.     

Seismic performance of corrugated steel plate concrete composite shear walls

In this paper, composite shear walls with different encased steel plates (flat, horizontal corrugated, and vertical corrugated) were tested and simulated by Abaqus to investigate the seismic behavior of corrugated steel plate concrete composite shear walls (SPCSWs). The failure characteristics, deformation and energy dissipation capacity, and stiffness and bearing capacity of the structures under low‐frequency cyclic load were analyzed, and indexes of the seismic performance were obtained. The formulas of the shear‐bearing capacity of steel plate concrete composite shear walls are suggested, and the shear‐sharing ratio of each member is obtained. According to the obtained results, corrugated steel plates can bond with concrete well, and the bearing capacity of the vertical corrugated SPCSW are higher than that of the horizontal corrugated SPCSW. Compared with flat SPCSW, corrugated SPCSW has higher initial stiffness and lateral stiffness, better ductility and energy dissipation ability, and the degradation of bearing capacity and stiffness is slower. The shear‐sharing ratio of a steel plate is larger than that of reinforced concrete in the flat SPCSW and the vertical corrugated SPCSW, the shear force shared by steel plate and reinforced concrete in horizontal corrugated SPCSW is basically the same.     

基于DEMATEL的装配式建筑成本影响因素分析

随着装配式建筑的广泛推广,其高居不下的建造成本已成为阻碍其推广的主要因素之一。为了掌握装配式建筑项目成本发展的变化规律,结合国内装配式建筑市场的现状以及我国装配式建筑成本的具体情况,从建造流程出发构建其成本的分析方法,从外部建设环境特征、项目自身技术特征、项目人员的组织管理三大方面分类归纳影响装配式建筑成本的主要因素,运用 DEMATEL 法得出各影响因素重要性水平以及互相之间的因果关系,依据数学模型推算结果,提出降低装配式建筑成本的措施与建议,进而促进其推广。     

影响原地爆破浸出效果的爆堆质量特征及其控制

根据原地爆破浸出工艺特点和硬岩浸出的扩散传质机制，对影响浸出效果的矿石块度、裂隙发育程度(矿石孔隙度)、矿堆孔隙度和矿堆渗透性能等爆破筑堆质量特征作了分析和讨论，确定了筑堆质量要求，并据此提出了质量控制的技术措施。     

硬质合金在牙轮钻头滑动轴承上的应用研究

在分析牙轮钻头轴承摩擦磨损机理的基础上，提出改进其轴承摩擦表面材料是提高其寿命的有效途径。通过对硬质合金的力学性能和摩擦学性质的分析，论证了硬质合金可以用于牙轮钻头滑动轴承摩擦表面，并提出了硬质合金脆性的解决方法。     

低污染铁矾法炼锌工艺的研究

本文研究了低污染铁矾法炼锌工艺过程,并将研究结果同澳大利亚Risdon厂的结果进行对比,讨论了低污染铁矾法炼锌的效益和铅、银回收。     

基于故障树分析的平巷运输事故可靠性计算

在平巷巷道中，敷设各种管路、电缆、设置风门等，对行车行人都有所不利。巷道年久变形失修、环境极端恶劣和司机违章操作、行人违章行走，从而造成运输事故屡有发生。应用可靠性设计中的故障树分析方法，分析导致平巷运输事故的原因，提出平巷运输事故的可靠性计算方法，将有助于提高矿井平巷运输系统的安全性，方法简洁适用。     

中国煤矿重大瓦斯爆炸事故规律分析

通过对中国煤矿1980年到2000年20年间发生的重大瓦斯爆炸事故和发生在国有重点煤矿的重大瓦斯爆炸事故的对比分析显示在所有导致中国煤矿重大瓦斯爆炸事故的直接原因中．人因(含故意违章45．89％、管理失误44．89％、缺陷设计6．90％)所占比率高达96．59％以上，这一数据在国有重点煤矿为人因(故意违章48．78％、管理失误35．36％、缺陷设计4．90％)占89．02％。这使我们对中国煤矿重大瓦斯爆炸事故的致因规律有了全新认识。在研究重大瓦斯爆炸事故环境特征、特征源交叉数据的基础上，对比得出中国煤矿雷大瓦斯爆怍事故规律图并分析。