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131.
Harry G. Sherman Jacqueline M. Hicks Akhil Jain Jeremy J. Titman Prof. Cameron Alexander Snow Stolnik Frankie J. Rawson 《Chembiochem : a European journal of chemical biology》2019,20(8):1008-1013
A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur through the action of cytosolic exudates rather than that of the membrane redox sites that normally control the oxidation state of iron as ferricyanide or ferrocyanide. The data demonstrate for the first time that mammalian cells can be used to initiate synthesis of conducting polymers and suggest a possible route to detection of cell damage and/or transcellular processes through in situ and amplifiable signal generation. 相似文献
132.
Stefan Wolf Jeremy W. Deuel Maija Hollmn Gunther Felmerer Bong-Sung Kim Mauro Vasella Lisanne Grünherz Pietro Giovanoli Nicole Lindenblatt Epameinondas Gousopoulos 《International journal of molecular sciences》2021,22(7)
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction. 相似文献
133.
Carolyn Moorlag Quanzu Yang Tom Troczynski Jeremy Bretherton Colin Fyfe 《Journal of the American Ceramic Society》2004,87(11):2064-2071
Aluminum phosphate products formed by the reactions of alumina and alumina-gel systems with acidic phosphates were analyzed. Drying of alumina-gel to form microcrystalline boehmite and conversion to γ-alumina by thermal treatment was indicated by the appearance of octahedral, pentacoordinate, or tetrahedral sites, which were established using 27 Al magic-angle-spinning solid-state nuclear magnetic resonance spectroscopy. Crystalline aluminum phosphate products and amorphous material were identified using this technique. α-alumina and heat-treated alumina-gel that were reacted with phosphate in an Al:P ratio of 1:1 yielded dramatically different aluminum orthophosphate:aluminum metaphosphate product ratios of 8.2:1 and 1:1.1, respectively. When alumina-gel was heat-treated with phosphate, an abundance of aluminum orthophosphate, aluminum metaphosphate, and hydrated aluminum phosphate products were affected by varying conditions of temperature and time of heat treatment and by the amount of phosphate present. An α-alumina/alumina-gel composite sol–gel phase that was reacted with phosphoric acid (H3 PO4 ) in a Al:P ratio of 1:1 exhibited an increased quantity of aluminum metaphosphate products compared with an α-alumina:H3 PO4 ratio of 1:1 and a higher percentage of reaction (79%) compared with the reactions of an α-alumina:H3 PO4 ratio of 1:1 or an alumina-gel:H3 PO4 ratio of 1:1. The morphologies of aluminum triphosphate hydrate and aluminum metaphosphate product phases were observed using scanning electron microscopy. 相似文献
134.
135.
In recent years, laser and electron beam welding techniques have been developed with heating rates reaching 1 million K/s, and nonequilibrium microstructures sometimes result. In the present study, the alpha (bcc) to gamma (fcc) transformation in pure iron is studied using a bank of storage batteries for heating and a high speed data acquisition system to monitor the temperature determined from a thermocouple spot welded to the specimen. Heating rates up to 300,000 K/s were obtained with the transformation temperature increasing from the equilibrium value of 1185 K (912 °C) to over 2200 K (1927 °C). The results are presented in terms of continuous heating and isothermal transformation curves. 相似文献
136.
Jeremy Bellay 《Dynamical Systems: An International Journal》2010,25(1):111-132
We investigate reaction–diffusion systems near parameter values that mark the transition from an excitable to an oscillatory medium. We analyse the existence and stability of travelling waves near a steep pulse that arises as the limit of excitation pulses when parameters cross into the oscillatory regime. Travelling waves near this limiting profile are obtained by analysing a codimension-two homoclinic saddle-node/orbit-flip bifurcation. The main result shows that there are precisely two generic scenarios for such a transition, distinguished by the sign of an interaction coefficient between pulses. In both scenarios, we find stable fast fronts, unstable slow fronts, stable excitation pulses, and trigger and phase waves. Both trigger and phase waves are stable for repulsive interaction and both are unstable for attractive interaction. 相似文献
137.
Adedeji B. Badiru Jeremy M. Slagley David A. Smith 《Canadian Metallurgical Quarterly》2010,136(1):39-47
This paper presents guidelines for applying project management tools and techniques to the process of preparing for a program accreditation site visit. The premise of the paper is that the proven tools and techniques of project management are effective in managing all the steps required in accreditation preparation as well as postvisit followups. The basic lesson offered by the paper’s approach is that accreditation preparation should not be turned into a last-minute crash project. Rather, proactive preparation steps should be instituted early to facilitate communication, cooperation, and coordination of the entire process. The guidelines provided in the paper are useful not only for program review, but also for continuous process and curriculum improvement. The paper cites two graduate program examples of Accreditation Board for Engineering and Technology, Inc. preparation at the Air Force Institute of Technology. 相似文献
138.
Vivian E. Ferry Jeremy N. Munday Harry A. Atwater 《Advanced materials (Deerfield Beach, Fla.)》2010,22(43):4794-4808
This paper reviews the recent research progress in the incorporation of plasmonic nanostructures with photovoltaic devices and the potential for surface plasmon enhanced absorption. We first outline a variety of cell architectures incorporating metal nanostructures. We then review the experimental fabrication methods and measurements to date, as well as systematic theoretical studies of the optimal nanostructure shapes. Finally we discuss photovoltaic absorber materials that could benefit from surface plasmon enhanced absorption. 相似文献
139.
140.
Wenbin Li Amir Ghazanfari Devin McMillen Ming C. Leu Gregory E. Hilmas Jeremy Watts 《Ceramics International》2018,44(11):12245-12252
The Ceramic On-Demand Extrusion (CODE) process is a novel additive manufacturing method for fabricating dense (~99% of theoretical density) ceramic components from aqueous, high solids loading pastes (>50?vol%). In this study, 3?mol% Y2O3 stabilized zirconia (3YSZ) specimens were fabricated using the CODE process. The specimens were then dried in a humidity-controlled environmental chamber and afterwards sintered under atmospheric conditions. Mechanical properties of the sintered specimens were examined using ASTM standard test techniques, including density, Young’s modulus, flexural strength, Weibull modulus, fracture toughness, and Vickers hardness. The microstructure was analyzed and grain size measured using scanning electron microscopy. The results were compared with those from Direct Inkjet Printing, Selective Laser Sintering, Lithography-based Ceramic Manufacturing (LCM), and other extrusion-based processes, and indicated that zirconia specimens produced by CODE exhibit superior mechanical properties among the additive manufacturing processes. Several sample components were produced to demonstrate CODE’s capability for fabricating geometrically complex ceramic components. The surface roughness of these components was also examined. 相似文献