Structuring and Molding of Electrospun Nanofibers: Effect of Electrical and Topographical Local Properties of Micro‐Patterned Collectors

The controlled deposition of electrospun nanofibers at the micro‐scale is studied. Several collectors with microscopic patterns are prepared using photolithography. Nanofiber deposition is influenced by the geometry, the size, and the distance between micro‐patterns. Within certain conditions, membranes with multiple “micro spider‐webs” or perpendicularly interconnected microgrids are obtained. Dielectric micro‐holes having a conductive bottom can be filled by the nanofiber. This kind of micro‐molding is rationalized using simulations that show the influence of the collector relative permittivity on the electric field at the pattern vicinity. “Micro‐woven” membranes of PCL with good mechanical properties can be produced, allowing their use for biomedical applications in tissue engineering.

     

High-inversion densities in Nd:YAG-upconversion and bleaching

We report on the investigation of upconversion in Nd:YAG and its implications for intensely pumped devices. Analysis of lifetime measurements and the performance of a 1 at.% Nd-doped YAG amplifier give an Auger upconversion rate of 7×10³ s^-1. This is significantly smaller than previously reported, but modeling of the performance of Nd:YAG devices with high-inversion densities shows that even this rate can still seriously degrade the small-signal gain and significantly increase the thermal load. The variation of cross-relaxation and upconversion rates with doping level is also described. Finally, it is found that the effect of bleaching of the Nd:YAG absorption can lead to a reduced spatial overlap between the signal and inversion profiles and thus can also significantly reduce the gain     

Using monte carlo simulation for accurate critical dimension metrology of super small isolated poly‐lines

With the reduction of critical dimensions (CD) of physical gate lines, standard methods for evaluating bottom CD from the scanning electron microscope (SEM) signal become inaccurate. The two peaks, originating from the line edges, merge into a single peak, and the correct position of the topographical top and bottom points is not clear. A general Monte Carlo simulation program, developed to model SEM signals, was used to analyze the signals emerging from ultra small silicon lines. By correlating the simulated signals with the features, we deduced the location of the top and bottom points. This analysis was done for lines with various CDs, sidewall angles, and corner rounding, as well as for different spot sizes. This work shows the feasibility of using SEM for measuring ultranarrow features and supply data for algorithm development.     

Radial pressure profiles in a cold‐flow gas‐solid vortex reactor

A unique normalized radial pressure profile characterizes the bed of a gas‐solid vortex reactor over a range of particle densities and sizes, solid capacities, and gas flow rates: 950–1240 kg/m³, 1–2 mm, 2 kg to maximum solids capacity, and 0.4–0.8 Nm³/s (corresponding to gas injection velocities of 55–110 m/s), respectively. The combined momentum conservation equations of both gas and solid phases predict this pressure profile when accounting for the corresponding measured particle velocities. The pressure profiles for a given type of particles and a given solids loading but for different gas injection velocities merge into a single curve when normalizing the pressures with the pressure value downstream of the bed. The normalized—with respect to the overall pressure drop—pressure profiles for different gas injection velocities in particle‐free flow merge in a unique profile. © 2015 The Authors AIChE Journal published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers AIChE J, 61: 4114–4125, 2015     

Reconstruction of chronic and complete dislocations of the acromioclavicular joint

The authors report on a technique for the treatment of symptomatic, chronic complete dislocations of the acromioclavicular joint. The coracoacromial ligament is substituted for the coracoclavicular ligaments, and a special temporary coracoclavicular lag screw is used to stabilize the clavicle to the coracoid during ligament healing. The technique has been used on 23 patients who were observed for an average of 5.2 years. Good to excellent results were obtained in 19 of 23 patients. The four patients with fair or poor results had one or more resections of the distal clavicle before the reconstruction. Subjectively, 22 of 23 patients reported improvement in their shoulder.     

Sum Coloring Interval and k -Claw Free Graphs with Application to Scheduling Dependent Jobs

We consider the sum coloring and sum multicoloring problems on several fundamental classes of graphs, including the classes of interval and k-claw free graphs. We give an algorithm that approximates sum coloring within a factor of 1.796, for any graph in which the maximum k-colorable subgraph problem is polynomially solvable. In particular, this improves on the previous best known ratio of 2 for interval graphs. We introduce a new measure of coloring, robust throughput}, that indicates how quickly the graph is colored, and show that our algorithm approximates this measure within a factor of 1.4575. In addition, we study the contiguous (or non-preemptive) sum multicoloring problem on k-claw free graphs. This models, for example, the scheduling of dependent jobs on multiple dedicated machines, where each job requires the exclusive use of at most k machines. Assuming that k is a fixed constant, we obtain the first constant factor approximation for the problem.     

Morphological,thermal, and mechanical properties of poly(ε‐caprolactone)/poly(ε‐caprolactone)‐grafted‐cellulose nanocrystals mats produced by electrospinning

Electrospun nanocomposites of poly(ε‐caprolactone) (PCL) incorporated with PCL‐grafted cellulose nanocrystals (PCL‐g‐CNC) were produced. PCL chains were grafted from cellulose nanocrystals (CNC) surface by ring‐opening polymerization. Grafting was confirmed by infrared spectroscopy (FTIR) and thermogravimetric analyses (TGA). The resulting PCL‐g‐CNC were then incorporated into a PCL matrix at various loadings. Homogeneous nanofibers with average diameter decreasing with the addition of PCL‐g‐CNC were observed by scanning electron microscopy (SEM). PCL‐g‐CNC domains incorporated into the PCL matrix were visualized by transmission electron microscopy (TEM). Thermal and mechanical properties of the mats were analyzed by differential scanning calorimetry (DSC), TGA and dynamic mechanical analysis (DMA). The addition of PCL‐g‐CNC into the PCL matrix caused changes in the thermal behavior and crystallinity of the electrospun fibers. Significant improvements in Young's modulus and in strain at break with increasing PCL‐g‐CNC loadings were found. These results highlighted the great potential of cellulose nanocrystals as a reinforcement phase in electrospun PCL mats, which can be used as biomedical materials. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43445.     

Replicative Stress Coincides with Impaired Nuclear DNA Damage Response in COX4-1 Deficiency

Cytochrome c oxidase (COX), a multimeric protein complex, is the final electron acceptor in the mitochondrial electron transfer chain. Primary COX deficiency, caused by mutations in either mitochondrial DNA or nuclear-encoded genes, is a heterogenous group of mitochondrial diseases with a wide range of presentations, ranging from fatal infantile to subtler. We previously reported a patient with primary COX deficiency due to a pathogenic variant in COX4I1 (encoding the common isoform of COX subunit 4, COX4-1), who presented with bone marrow failure, genomic instability, and short stature, mimicking Fanconi anemia (FA). In the present study, we demonstrated that accumulative DNA damage coincided primarily with proliferative cells in the patient’s fibroblasts and in COX4i1 knockdown cells. Expression analysis implicated a reduction in DNA damage response pathways, which was verified by demonstrating impaired recovery from genotoxic insult and decreased DNA repair. The premature senescence of the COX4-1-deficient cells prevented us from undertaking additional studies; nevertheless, taken together, our results indicate replicative stress and impaired nuclear DNA damage response in COX4-1 deficiency. Interestingly, our in vitro findings recapitulated the patient’s presentation and present status.     

An evaluation of the impact of SG1 disproportionation and the addition of styrene in NMP of methyl methacrylate

A kinetic modeling study is presented for batch nitroxide mediated polymerization (NMP) of methyl methacrylate (MMA; nitroxide: N‐tert‐butyl‐N‐[1‐diethylphosphono‐(2,2‐dimethylpropyl)] (SG1)). Arrhenius parameters for SG1 disproportionation (A = 1.4 10⁷ L mol^?1 s^?1; E_a = 23 kJ mol^?1) are reported, based on homopolymerization data accounting for unavoidable temperature variations with increasing time, that is, nonisothermicity. For low targeted chain lengths (TCLs ≤ 300), this nonisothermicity is also relevant for NMP of MMA with a small amount of styrene. Parameter tuning to copolymerization data confirms a penultimate monomer unit effect for activation (s_a2 = k_a12/k_a22=6.7; 363 K; 1: MMA; 2: styrene). To obtain, for a broad TCL range (up to 800), a dispersity well below 1.3 an initial styrene mass fraction of ca. 10% is required. An interpretation of the comonomer incorporation is performed by calculating the fractions of activation‐growth‐deactivation cycles with a given amount of monomer units and the copolymer composition distribution. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2545–2559, 2018