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排序方式: 共有2869条查询结果,搜索用时 15 毫秒
91.
In recent years, various proposals have been put forth to formalize the Grafcet graphical language. The objective of this paper is to propose an ontology-based approach to formalize this language. The authors have implemented a semi-coarse grain ontology written in Ontology Web Language and have tested it by including it in an existing educational tool for the teaching of Grafcet language for use in programmable logic controllers. 相似文献
92.
Dr. Jakob Franke Dr. Jeongwoon Kim John P. Hamilton Dr. Dongyan Zhao Gina M. Pham Krystle Wiegert-Rininger Emily Crisovan Linsey Newton Brieanne Vaillancourt Dr. Evangelos Tatsis Prof. Dr. C. Robin Buell Prof. Dr. Sarah E. O'Connor 《Chembiochem : a European journal of chemical biology》2019,20(1):83-87
Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information is not commonly used to identify novel biosynthesis genes. Here, we present the genome of the medicinal plant and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium sempervirens (Gelsemiaceae). A gene cluster from Catharanthus roseus, which is utilized at least six enzymatic steps downstream from the last common intermediate shared between the two plant alkaloid types, is found in G. sempervirens, although the corresponding enzymes act on entirely different substrates. This study provides insights into the common genomic context of MIA pathways and is an important milestone in the further elucidation of the Gelsemium oxindole alkaloid pathway. 相似文献
93.
Gross Jürgen Peter Malzbender Jürgen Schwaiger Ruth 《Journal of Materials Science》2022,57(15):7481-7490
Journal of Materials Science - The application of ceramics in advanced functional applications often requires thicknesses below a few hundred micrometers, rendering an assessment of the... 相似文献
94.
We investigate deformation and failure of Al 6061-T6 in plane strain conditions through in situ scanning electron microscopy. The global behavior of the specimen, as well as the local deformation of the matrix material, second phase particles, and preexisting voids, is observed with a combination of high temporal/low spatial resolution images and low temporal/high spatial resolution images. It is found that the matrix dominates the deformation response, with the second phase particles and voids imparting little influence on the deformation under the moderate triaxiality levels encountered in this experiment. The initiation or nucleation of cracks is observed to occur by plastic slip. 相似文献
95.
Tejminder S. Sidhu Shauna L. French Justin R. Hamilton 《International journal of molecular sciences》2014,15(4):6169-6183
Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that exhibit increasingly appreciated differences in signaling and regulation both within and between the receptor class. By nature of their proteolytic self-activation mechanism, PARs have unique processes of receptor activation, “ligand” binding, and desensitization/resensitization. These distinctive aspects have presented both challenges and opportunities in the targeting of PARs for therapeutic benefit—the most notable example of which is inhibition of PAR1 on platelets for the prevention of arterial thrombosis. However, more recent studies have uncovered further distinguishing features of PAR-mediated signaling, revealing mechanisms by which identical proteases elicit distinct effects in the same cell, as well as how distinct proteases produce different cellular consequences via the same receptor. Here we review this differential signaling by PARs, highlight how important distinctions between PAR1 and PAR4 are impacting on the progress of a new class of anti-thrombotic drugs, and discuss how these more recent insights into PAR signaling may present further opportunities for manipulating PAR activation and signaling in the development of novel therapies. 相似文献
96.
Ian G. Hamilton David Shipworth Alex J. Summerfield Philip Steadman Tadj Oreszczyn Robert Lowe 《Building Research & Information》2014,42(3):255-275
Little detailed evidence has previously been available regarding the uptake rate or prevalence of energy efficiency interventions among specific household groups. This study uses the Home Energy Efficiency Database (HEED) to investigate both the combination of measures that have been installed, and in which dwellings, according to key neighbourhood socio-demographic variables, including income and tenure. Analysis of 2000–07 data indicates that approximately 40% (9.3 million) dwellings in England had approximately 23.7 million efficiency measures installed, with an average of 2.5 measures per dwelling. Building fabric-related measures were the most frequent (e.g. cavity wall insulation, loft insulation and glazing) with an average of 2.1 million installed each year. Dwellings with the highest number of fabric interventions (the top 20%) were more likely to be found in areas with low income, with more owner-occupied dwellings, experiencing lower winter temperatures, having a lower proportion of flats, and having a slightly higher proportion of older adults and children. Energy efficiency installations have tended to occur among specific types of households or parts of the building stock. These findings have implications for the design of future government programmes for targeting energy efficiency measures to specific household groups or dwelling types. 相似文献
97.
Srivastava Sanjay; Tamir Maya; McGonigal Kelly M.; John Oliver P.; Gross James J. 《Canadian Metallurgical Quarterly》2009,96(4):883
There is growing interest in understanding how emotion regulation affects adaptation. The present study examined expressive suppression (which involves inhibiting the overt expression of emotion) and how it affects a critical domain of adaptation, social functioning. This investigation focused on the transition to college, a time that presents a variety of emotional and social challenges. Analyses focused on 2 components of suppression: a stable component, representing individual differences expressed both before and after the transition, and a dynamic component, representing variance specific to the new college context. Both components of suppression predicted lower social support, less closeness to others, and lower social satisfaction. These findings were robustly corroborated across weekly experience reports, self-reports, and peer reports and are consistent with a theoretical framework that defines emotion regulation as a dynamic process shaped by both stable person factors and environmental demands. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
98.
Miguel A. Otaduy Rasmus Tamstorf Denis Steinemann Markus Gross 《Computer Graphics Forum》2009,28(2):559-568
We present an algorithm for robust and efficient contact handling of deformable objects. By being aware of the internal dynamics of the colliding objects, our algorithm provides smooth rolling and sliding, stable stacking, robust impact handling, and seamless coupling of heterogeneous objects, all in a unified manner. We achieve dynamicsawareness through a constrained dynamics formulation with implicit complementarity constraints, and we present two major contributions that enable an efficient solution of the constrained dynamics problem: a time stepping algorithm that robustly ensures non-penetration and progressively refines the formulation of constrained dynamics, and a new solver for large mixed linear complementarity problems, based on iterative constraint anticipation. We show the application of our algorithm in challenging scenarios such as multi-layered cloth moving at high velocities, or colliding deformable solids simulated with large time steps. 相似文献
99.
Therese P. McAllister John L. Gross Fahim Sadek Steven Kirkpatrick Robert A. MacNeill Mehdi Zarghamee Omer O. Erbay Andrew T. Sarawit 《Fire Technology》2013,49(3):709-739
The National Institute of Standards and Technology (NIST) conducted an extensive investigation of the collapse of World Trade Center towers (WTC 1 and WTC 2) and the WTC 7 building. This paper describes the component, subsystem, and global analyses performed for the reconstruction of the structural response of WTC buildings 1, 2, and 7 to impact and fire damage. To illustrate the component and subsystem analyses, the approach taken for simulating the performance of concrete slabs and shear stud connectors in composite floors subject to fire conditions are presented, as well as steel floor framing connections for beams and girders. The development of the global models from the component and subsystem analyses is briefly described, including the sets of input data used to bound the probable conditions of impact and fire damage. The final analysis results that were used to develop the probable collapse hypotheses, and a comparison of the results against observed events, are presented for each building. A review of research activities focused on improving understanding of structural system response to multi-floor fires following the WTC disaster is also provided. 相似文献
100.
I. C. Kemp T. Hartwig R. Herdman P. Hamilton A. Bisten S. Bermingham 《Drying Technology》2016,34(10):1243-1252
This article presents experimental and modeling work to complete previously reported work on spray drying. Back-calculated droplet sizes have been verified by measurements with a laser imaging rig. Flow patterns in a cylindrical spray chamber have been simulated by computational fluid dynamics and demonstrated that droplet residence times are much shorter than expected. A droplet tracking population balance model has been implemented in gSOLIDS and shows how drying times vary with droplet diameter. Particle collection by cyclone and bag filter have also been compared experimentally. 相似文献