Direct magnetic problem solved by quaternion analog of 3-D Cauchy-Riemann system

Contents By applying the quaternion variant of the Cauchy integral formula the general solution of the direct magnetic problem is derived. The applicability of the method presented here is shown by investigating and calculating the outer field of a analytically magnetized sphere.

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Die Lösung der direkten Aufgabe der Magnetik mit Hilfe des Quaternionen Analogons des 3-D Cauchy-Riemann Systems

Übersicht Die allgemeine Lösung der direkten Aufgabe der Magnetik wird mit Hilfe der Quaternionenvariante des Cauchy-Integrals abgeleitet. Die Anwendbarkeit der vorgestellten, Methode wird am Beispiel des berechneten äußeren magnetischen Feldes einer analytisch magnetisierten Kugel untersucht.

     

Optimal synchronous pulsewidth modulation with atrajectory-tracking scheme for high-dynamic performance

Synchronous pulse-width modulation (PWM) based on precalculated and stored optimal pulse patterns could be a superior method for the control of high-power inverters operated at low switching frequency. The technique has rarely been applied in practice owing to its poor dynamic performance. A novel feedforward control technique eliminates this decisive drawback: the space vector of the machine currents is forced to track a precalculated optimal trajectory in the steady-state and under the transient operating conditions commanded by the drive control system. Undesired transients caused by the pulse-width modulator are avoided. Experimental results obtained from a 30 kW AC drive are presented     

Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells

The aim of this study was to analyze the expression of peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RxRα), a binding heterodimer playing a pivotal role in the successful trophoblast invasion, in the placental tissue of preeclamptic patients. Furthermore, we aimed to characterize a possible interaction between PPARγ and H3K4me3 (trimethylated lysine 4 of the histone H3), respectively H3K9ac (acetylated lysine 9 of the histone H3), to illuminate the role of histone modifications in a defective trophoblast invasion in preeclampsia (PE). Therefore, the expression of PPARγ and RxRα was analyzed in 26 PE and 25 control placentas by immunohistochemical peroxidase staining, as well as the co-expression with H3K4me3 and H3K9ac by double immunofluorescence staining. Further, the effect of a specific PPARγ-agonist (Ciglitazone) and PPARγ-antagonist (T0070907) on the histone modifications H3K9ac and H3K4me3 was analyzed in vitro. In PE placentas, we found a reduced expression of PPARγ and RxRα and a reduced co-expression with H3K4me3 and H3K9ac in the extravillous trophoblast (EVT). Furthermore, with the PPARγ-antagonist treated human villous trophoblast (HVT) cells and primary isolated EVT cells showed higher levels of the histone modification proteins whereas treatment with the PPARγ-agonist reduced respective histone modifications. Our results show that the stimulation of PPARγ-activity leads to a reduction of H3K4me3 and H3K9ac in trophoblast cells, but paradoxically decreases the nuclear PPARγ expression. As the importance of PPARγ, being involved in a successful trophoblast invasion has already been investigated, our results reveal a pathophysiologic connection between PPARγ and the epigenetic modulation via H3K4me3 and H3K9ac in PE.     

Off-Pathway-Sensitive Protein-Splicing Screening Based on a Toxin/Antitoxin System

Protein-splicing domains are frequently used engineering tools that find application in the in vivo and in vitro ligation of protein domains. Directed evolution is among the most promising technologies used to advance this technology. However, the available screening systems for protein-splicing activity are associated with bottlenecks such as the selection of pseudo-positive clones arising from off-pathway reaction products or fragment complementation. Herein, we report a stringent screening method for protein-splicing activity in cis and trans, that exclusively selects productively splicing domains. By fusing splicing domains to an intrinsically disordered region of the antidote from the Escherichia coli CcdA/CcdB type II toxin/antitoxin system, we linked protein splicing to cell survival. The screen allows selecting novel cis- and trans-splicing inteins catalyzing productive highly efficient protein splicing, for example, from directed-evolution approaches or the natural intein sequence space.     

Qualms regarding the optimality of cumulative path length control in CSA/CMA-evolution strategies

Cumulative step-size adaptation (CSA) based on path length control is regarded as a robust alternative to the standard mutative self-adaptation technique in evolution strategies (ES), guaranteeing an almost optimal control of the mutation operator. This paper shows that the underlying basic assumption in CSA--the perpendicularity of expected consecutive steps--does not necessarily guarantee optimal progress performance for (mu/mu(I), lambda) intermediate recombinative ES.     

Optimum tracking with evolution strategies

Evolutionary algorithms are frequently applied to dynamic optimization problems in which the objective varies with time. It is desirable to gain an improved understanding of the influence of different genetic operators and of the parameters of a strategy on its tracking performance. An approach that has proven useful in the past is to mathematically analyze the strategy's behavior in simple, idealized environments. The present paper investigates the performance of a multiparent evolution strategy that employs cumulative step length adaptation for an optimization task in which the target moves linearly with uniform speed. Scaling laws that quite accurately describe the behavior of the strategy and that greatly contribute to its understanding are derived. It is shown that in contrast to previously obtained results for a randomly moving target, cumulative step length adaptation fails to achieve optimal step lengths if the target moves in a linear fashion. Implications for the choice of population size parameters are discussed.     

Correction to: Reliable benchmarking: requirements and solutions

International Journal on Software Tools for Technology Transfer - The article Reliable benchmarking: requirements and solutions.     

Efficient relational calculation for software analysis

Calculating with graphs and relations has many applications in the analysis of software systems, for example, the detection of design patterns or patterns of problematic design and the computation of design metrics. These applications require an expressive query language, in particular, for the detection of graph patterns, and an efficient evaluation of the queries even for large graphs. In this paper, we introduce RML, a simple language for querying and manipulating relations based on predicate calculus, and CrocoPat, an interpreter for RML programs. RML is general because it enables the manipulation not only of graphs (i.e., binary relations), but of relations of arbitrary arity. CrocoPat executes RML programs efficiently because it internally represents relations as binary decision diagrams, a data structure that is well-known as a compact representation of large relations in computer-aided verification. We evaluate RML by giving example programs for several software analyses and CrocoPat by comparing its performance with calculators for binary relations, a Prolog system, and a relational database management system.     

Parallel dynamic and kinetic regular triangulation in three dimensions

A parallel algorithm for regular triangulations is presented. For the purpose of fully dynamic and kinetic particle simulations it allows vertex insertion, deletion, movement, and weight changes. We describe new algorithms for incremental construction of regular triangulations, parallel vertex deletion and insertion. Finally, a parallel Lawson flip algorithm for vertex displacements is presented. The performance analysis demonstrates a significant parallel efficiency for various system sizes and performed changes.