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11.
Commercial organizations increasingly need software processes sensitive to busi- ness value, quick to apply, supportive of multi-stakeholder collaboration, and capable of early analysis for subprocess consistency and compatibility. This paper and a companion paper \Applying Value-Based Software Process: An ERP Example" present our experience in ap- plying a lightweight synthesis of a Value-Based Software Quality Achievement (VBSQA) process and an Object-Petri-Net (OPN) based process model to achieve a stakeholder win- win outcome for software quality achievement in an ERP software project in China. We attempt to answer such questions as (1) whether it is possible to model various project stakeholder perspectives using formal process modeling languages in a real-world project? (2) how to make stakeholders synchronize and stabilize their value propositions, activities and commitments as needed. The companion paper presents the VBSQA process and its application to the ERP project; this paper presents the OPN-based process modeling and its application. The application results of OPN process modeling conˉrmed that (1) the OPN- based process model provided project managers with a synchronization and stabilization framework for process activities, success-critical stakeholders and their value propositions; (2) process visualization and simulation tools signiˉcantly increased management visibility and controllability for the success of the software project.  相似文献   
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A series of high hectorite content nanocomposite Poly (N-isopropylacrylamide), (PNIPAAm), hydrogels have been successfully synthesized by choosing a special kind of hectorite (Laponite XLS) modified by tetrasodium pyrophosphate. It was found that these hydrogels show surprising mechanical properties (i.e. tensile strength: 1 MPa, elongation at break: 1400%) and complicated deswelling behavior, which are due to the high clay content of the hydrogels and ionic dispersant contained in Laponite XLS, respectively.  相似文献   
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A major problem in empirical software engineering is to determine or ensure comparability across multiple sources of empirical data. This paper summarizes experiences in developing and applying a software engineering technology testbed. The testbed was designed to ensure comparability of empirical data used to evaluate alternative software engineering technologies, and to accelerate the technology maturation and transition into project use. The requirements for such software engineering technology testbeds include not only the specifications and code, but also the package of instrumentation, scenario drivers, seeded defects, experimentation guidelines, and comparative effort and defect data needed to facilitate technology evaluation experiments. The requirements and architecture to build a particular software engineering technology testbed to help NASA evaluate its investments in software dependability research and technology have been developed and applied to evaluate a wide range of technologies. The technologies evaluated came from the fields of architecture, testing, state-model checking, and operational envelopes. This paper will present for the first time the requirements and architecture of the software engineering technology testbed. The results of the technology evaluations will be analyzed from a point of view of how researchers benefitted from using the SETT. The researchers just reported how their technology performed in their original findings. The testbed evaluation showed (1) that certain technologies were complementary and cost-effective to apply; (2) that the testbed was cost-effective to use by researchers within a well-specified domain of applicability; (3) that collaboration in testbed use by researchers and the practitioners resulted comparable empirical data and in actions to accelerate technology maturity and transition into project use, as shown in the AcmeStudio evaluation; and (4) that the software engineering technology testbed’s requirements and architecture were suitable for evaluating technologies and accelerating their maturation and transition into project use.
Barry BoehmEmail:
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More than half the literature on software effort estimation (SEE) focuses on comparisons of new estimation methods. Surprisingly, there are no studies comparing state of the art latest methods with decades-old approaches. Accordingly, this paper takes five steps to check if new SEE methods generated better estimates than older methods. Firstly, collect effort estimation methods ranging from “classical” COCOMO (parametric estimation over a pre-determined set of attributes) to “modern” (reasoning via analogy using spectral-based clustering plus instance and feature selection, and a recent “baseline method” proposed in ACM Transactions on Software Engineering). Secondly, catalog the list of objections that lead to the development of post-COCOMO estimation methods. Thirdly, characterize each of those objections as a comparison between newer and older estimation methods. Fourthly, using four COCOMO-style data sets (from 1991, 2000, 2005, 2010) and run those comparisons experiments. Fifthly, compare the performance of the different estimators using a Scott-Knott procedure using (i) the A12 effect size to rule out “small” differences and (ii) a 99 % confident bootstrap procedure to check for statistically different groupings of treatments. The major negative result of this paper is that for the COCOMO data sets, nothing we studied did any better than Boehms original procedure. Hence, we conclude that when COCOMO-style attributes are available, we strongly recommend (i) using that data and (ii) use COCOMO to generate predictions. We say this since the experiments of this paper show that, at least for effort estimation, how data is collected is more important than what learner is applied to that data.  相似文献   
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Here we report results from a multi-laboratory (n = 11) evaluation of four different PCR methods targeting the 16S rRNA gene of Catellicoccus marimammalium originally developed to detect gull fecal contamination in coastal environments. The methods included a conventional end-point PCR method, a SYBR® Green qPCR method, and two TaqMan® qPCR methods. Different techniques for data normalization and analysis were tested. Data analysis methods had a pronounced impact on assay sensitivity and specificity calculations. Across-laboratory standardization of metrics including the lower limit of quantification (LLOQ), target detected but not quantifiable (DNQ), and target not detected (ND) significantly improved results compared to results submitted by individual laboratories prior to definition standardization. The unit of measure used for data normalization also had a pronounced effect on measured assay performance. Data normalization to DNA mass improved quantitative method performance as compared to enterococcus normalization. The MST methods tested here were originally designed for gulls but were found in this study to also detect feces from other birds, particularly feces composited from pigeons. Sequencing efforts showed that some pigeon feces from California contained sequences similar to C. marimammalium found in gull feces. These data suggest that the prevalence, geographic scope, and ecology of C. marimammalium in host birds other than gulls require further investigation. This study represents an important first step in the multi-laboratory assessment of these methods and highlights the need to broaden and standardize additional evaluations, including environmentally relevant target concentrations in ambient waters from diverse geographic regions.  相似文献   
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FKBP5 encodes FK506-binding protein 5, a glucocorticoid receptor (GR)-binding protein implicated in various psychiatric disorders and alcohol withdrawal severity. The purpose of this study is to characterize alcohol preference and related phenotypes in Fkbp5 knockout (KO) mice and to examine the role of FKBP5 in human alcohol consumption. The following experiments were performed to characterize Fkpb5 KO mice. (1) Fkbp5 KO and wild-type (WT) EtOH consumption was tested using a two-bottle choice paradigm; (2) The EtOH elimination rate was measured after intraperitoneal (IP) injection of 2.0 g/kg EtOH; (3) Blood alcohol concentration (BAC) was measured after 3 h limited access of alcohol; (4) Brain region expression of Fkbp5 was identified using LacZ staining; (5) Baseline corticosterone (CORT) was assessed. Additionally, two SNPs, rs1360780 (C/T) and rs3800373 (T/G), were selected to study the association of FKBP5 with alcohol consumption in humans. Participants were college students (n = 1162) from 21–26 years of age with Chinese, Korean or Caucasian ethnicity. The results, compared to WT mice, for KO mice exhibited an increase in alcohol consumption that was not due to differences in taste sensitivity or alcohol metabolism. Higher BAC was found in KO mice after 3 h of EtOH access. Fkbp5 was highly expressed in brain regions involved in the regulation of the stress response, such as the hippocampus, amygdala, dorsal raphe and locus coeruleus. Both genotypes exhibited similar basal levels of plasma corticosterone (CORT). Finally, single nucleotide polymorphisms (SNPs) in FKBP5 were found to be associated with alcohol drinking in humans. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.  相似文献   
20.
The oscillation of argon oxygen decarburization (AOD) converters is flow related and depends on the process parameters (e.g., vessel geometry, melt fill height, process gas type and blowing rate, vessel tilting angle, as well as geometry, number, and arrangement of the side-wall nozzles). For a 120-ton AOD converter with seven submerged side-wall nozzles, plant tests, physical simulations on a 1:4 scale water model, and computational fluid dynamics simulations have been done. The investigations show that the penetration depth of an inert gas jet into the melt does not exceed approximately 0.4 m. The plumes are located close to the nozzle-side converter wall and induce a large-scale primary vortex as well as intensive surface movements; both are responsible for the oscillation. Several process mechanisms were investigated. The oscillation is highest in the last stage of the dynamic blow and is still high during the reduction stage. As the amount of inert gas increases, the vibration level also increases. Inert gas has a greater influence on the oscillation than oxygen. Tilting the converter around 8 deg clearly leads to more intensive oscillations. Increasing the blowing rate increases the forces and torques acting on the vessel, whereas the oscillation frequency remains nearly constant. A varying fill level does not influence the vibration level the same way as the blowing rate. The operational test shows, for example, that the maximum torque does not depend on the heat size when the latter varies between –8 pct and +21 pct of the nominal heat size. The water model test shows decreasing forces and torques with a rising fill level.  相似文献   
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